Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin (Q38200047)

30 August 2017

title

Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin (English)

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30 August 2017

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ChEBI release 2020-05-28

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677503 AND SRC:MED&resulttype=core&format=json

11 June 2020

Ryo C. Yanagita

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677503 AND SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Kazuhiro Irie

series ordinal

1

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30 August 2017

Ryo C Yanagita

series ordinal

2

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30 August 2017

publication date

20 February 2014

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30 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677503 AND SRC:MED&resulttype=core&format=json

11 June 2020

volume

14

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11 June 2020

issue

2

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11 June 2020

page(s)

251-267

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677503 AND SRC:MED&resulttype=core&format=json

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

11 June 2020

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Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

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Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.

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Identification and biological activities of bryostatins from Japanese bryozoan.

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21 January 2018

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The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses

21 January 2018

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Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

21 January 2018

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21 January 2018

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The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line

21 January 2018

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Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action

21 January 2018

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Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxin, a Tumor Promoter

21 January 2018

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Estimation of tumor promoting activity and structure-function relationships of aplysiatoxins

21 January 2018

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Tumor promotion by depleting cells of protein kinase C delta

21 January 2018

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The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival

21 January 2018

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A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.

21 January 2018

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Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity

21 January 2018

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Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.

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Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.

21 January 2018

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Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.

21 January 2018

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Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin

21 January 2018

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Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.

21 January 2018

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Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis

21 January 2018

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Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis

21 January 2018

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Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta

21 January 2018

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Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death

21 January 2018

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Protein kinase C delta is required for survival of cells expressing activated p21RAS

21 January 2018

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RasGRPs are targets of the anti-cancer agent ingenol-3-angelate

21 January 2018

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Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia

21 January 2018

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Cytosolic-nuclear tumor promoter-specific binding protein (CN-TPBP) in human promyelocytic leukemia cells HL-60.

21 January 2018

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Isolation and structure of bryostatin 1

21 January 2018

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https://api.crossref.org/works/10.1002/TCR.201300036

Synthesis of bryostatin 7

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/TCR.201300036

Total Synthesis of Bryostatin 2

21 January 2018

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https://api.crossref.org/works/10.1002/TCR.201300036

Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin

21 January 2018

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Halichondrins - antitumor polyether macrolides from a marine sponge

21 January 2018

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20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC198658050701

Identifiers

DOI

10.1002/TCR.201300036

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24677503 AND SRC:MED&resulttype=core&format=json

11 June 2020

1 reference