Targeting the pancreatic β-cell to treat diabetes (Q38187862)

30 August 2017

title

Targeting the pancreatic β-cell to treat diabetes (English)

1 reference

30 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Amit Choudhary

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

Sean M Burns

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

Bridget K Wagner

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

publication date

14 February 2014

1 reference

Nature Reviews Drug Discovery

30 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

278-289

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24525781 AND SRC:MED&resulttype=core&format=json

Diabetes mellitus and the β cell: the last ten years

5 June 2020

cites work

1 reference

Genetics, pathogenesis and clinical interventions in type 1 diabetes

21 January 2018

1 reference

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

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The stunned beta cell: a brief history

21 January 2018

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Mechanisms for insulin resistance: common threads and missing links

21 January 2018

1 reference

Genetic and biochemical pathways of beta-cell failure in type 2 diabetes.

21 January 2018

1 reference

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

21 January 2018

1 reference

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

21 January 2018

1 reference

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

21 January 2018

1 reference

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

21 January 2018

1 reference

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes

21 January 2018

1 reference

beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes

21 January 2018

1 reference

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

21 January 2018

1 reference

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

21 January 2018

1 reference

Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes

21 January 2018

1 reference

Impaired islet turnover in human donor pancreata with aging.

21 January 2018

1 reference

Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.

21 January 2018

1 reference

Molecular control of cell cycle progression in the pancreatic beta-cell

21 January 2018

1 reference

Intrinsic regulators of pancreatic beta-cell proliferation

21 January 2018

1 reference

Regulation of beta cell replication.

21 January 2018

1 reference

p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

1 reference

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

21 January 2018

1 reference

p27 Regulates the transition of beta-cells from quiescence to proliferation

21 January 2018

1 reference

Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

21 January 2018

1 reference

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

21 January 2018

1 reference

Human pancreatic β-cell G1/S molecule cell cycle atlas

21 January 2018

1 reference

Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control

21 January 2018

1 reference

Expansion of beta-cell mass in response to pregnancy

21 January 2018

1 reference

Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion

21 January 2018

1 reference

Molecular mechanism of pancreatic β-cell adaptive proliferation: studies during pregnancy in rats and in vitro

21 January 2018

1 reference

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

21 January 2018

1 reference

Serotonin regulates pancreatic beta cell mass during pregnancy

21 January 2018

1 reference

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

21 January 2018

1 reference

Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.

21 January 2018

1 reference

Systemic regulation of the age-related decline of pancreatic β-cell replication

21 January 2018

1 reference

RETRACTED: Betatrophin: a hormone that controls pancreatic β cell proliferation

21 January 2018

1 reference

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

21 January 2018

1 reference

PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a

21 January 2018

1 reference

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

21 January 2018

1 reference

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.

21 January 2018

1 reference

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

Chemical methods to induce Beta-cell proliferation

21 January 2018

1 reference

Small-molecule inducer of β cell proliferation identified by high-throughput screening.

21 January 2018

1 reference

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

21 January 2018

1 reference

Adenosine signaling promotes regeneration of pancreatic β cells in vivo

21 January 2018

1 reference

Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity

21 January 2018

1 reference

EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes

21 January 2018

1 reference

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation

21 January 2018

1 reference

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

21 January 2018

1 reference

MicroRNA expression is required for pancreatic islet cell genesis in the mouse

21 January 2018

1 reference

Expression of islet-specific microRNAs during human pancreatic development

21 January 2018

1 reference

A pancreatic islet-specific microRNA regulates insulin secretion

21 January 2018

1 reference

Diabetes mellitus, a microRNA-related disease?

21 January 2018

1 reference

Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs

21 January 2018

1 reference

MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells

21 January 2018

1 reference

Quantitative differential expression analysis reveals miR-7 as major islet microRNA.

21 January 2018

1 reference

MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas

21 January 2018

1 reference

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis

21 January 2018

1 reference

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells

21 January 2018

1 reference

The good turned ugly: immunopathogenic basis for diabetogenic CD8 T cells in NOD mice

21 January 2018

1 reference

Genetics of type 1A diabetes

21 January 2018

1 reference

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis

21 January 2018

1 reference

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

21 January 2018

1 reference

Pancreatic islets under attack: cellular and molecular effectors

21 January 2018

1 reference

Autoimmune destruction of pancreatic beta cells.

21 January 2018

1 reference

Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse

21 January 2018

1 reference

Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic β-cells.

21 January 2018

1 reference

The role of perforin and granzymes in diabetes.

21 January 2018

1 reference

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

21 January 2018

1 reference

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

21 January 2018

1 reference

Prevention of type 1 diabetes: from the view point of beta cell damage

21 January 2018

1 reference

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

21 January 2018

1 reference

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

21 January 2018

1 reference

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

21 January 2018

1 reference

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation

21 January 2018

1 reference

Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation

21 January 2018

1 reference

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

21 January 2018

1 reference

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

21 January 2018

1 reference

Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway

21 January 2018

1 reference

Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappaB activation

21 January 2018

1 reference

Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line

21 January 2018

1 reference

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

21 January 2018

1 reference

Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

21 January 2018

1 reference

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

21 January 2018

1 reference

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

21 January 2018

1 reference

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

1 reference

Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1β antibody, in patients with type 2 diabetes

21 January 2018

1 reference

Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

21 January 2018

1 reference

Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice

21 January 2018

1 reference

Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis

21 January 2018

1 reference

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

21 January 2018

1 reference

Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.

21 January 2018

1 reference

Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis

21 January 2018

1 reference

Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility

21 January 2018

1 reference

The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

1 reference

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

21 January 2018

1 reference

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

21 January 2018

1 reference

Type 2 diabetes-a matter of beta-cell life and death?

21 January 2018

1 reference

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

21 January 2018

1 reference

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

1 reference

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

21 January 2018

1 reference

9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication

21 January 2018

1 reference

Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes

21 January 2018

1 reference

Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.

21 January 2018

1 reference

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity

21 January 2018

1 reference

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

21 January 2018

1 reference

Rosiglitazone inhibits early stage of glucolipotoxicity-induced beta-cell apoptosis.

21 January 2018

1 reference

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

21 January 2018

1 reference

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

21 January 2018

1 reference

Stem cell approaches for diabetes: towards beta cell replacement

21 January 2018

1 reference

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

21 January 2018

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds

21 January 2018

1 reference

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

21 January 2018

1 reference

A scalable system for production of functional pancreatic progenitors from human embryonic stem cells

21 January 2018

1 reference

Grand Challenge Commentary: Chemical transdifferentiation and regenerative medicine

21 January 2018

1 reference

Conversion of mature human β-cells into glucagon-producing α-cells.

21 January 2018

1 reference

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

21 January 2018

1 reference

Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers

21 January 2018

1 reference

Transcriptomes of the major human pancreatic cell types.

21 January 2018

1 reference

Opposing actions of Arx and Pax4 in endocrine pancreas development

21 January 2018

1 reference

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes

21 January 2018

1 reference

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

21 January 2018

1 reference

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

21 January 2018

1 reference

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

21 January 2018

1 reference

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming

21 January 2018

1 reference

Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells.

21 January 2018

1 reference

Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA

21 January 2018

1 reference

Type 2 diabetes: principles of pathogenesis and therapy

21 January 2018

1 reference

Key considerations around the risks and consequences of hypoglycaemia in people with type 2 diabetes

21 January 2018

1 reference

Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus

21 January 2018

1 reference

Assessing the potential of glucokinase activators in diabetes therapy

21 January 2018

1 reference

Glucokinase activators for diabetes therapy: May 2010 status report

21 January 2018

1 reference

Small molecular glucokinase activators: has another new anti-diabetic therapeutic lost favour?

21 January 2018

1 reference

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

21 January 2018

1 reference

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

21 January 2018

1 reference

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

21 January 2018

1 reference

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

21 January 2018

1 reference

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

21 January 2018

1 reference

The genetics of type 2 diabetes: what have we learned from GWAS?

21 January 2018

1 reference

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

21 January 2018

1 reference

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 January 2018

1 reference

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

21 January 2018

1 reference

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

21 January 2018

1 reference

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

1 reference

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

1 reference

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

1 reference

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

1 reference

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

21 January 2018

1 reference

Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing

21 January 2018

1 reference

Open Innovation for Phenotypic Drug Discovery: The PD2 Assay Panel

21 January 2018

1 reference

An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production

21 January 2018

1 reference

A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression

21 January 2018

1 reference

Genomic analysis at the single-cell level

21 January 2018

1 reference

Microbial environments confound antibiotic efficacy

21 January 2018

1 reference

Genome engineering at the dawn of the golden age.

21 January 2018

1 reference

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

21 January 2018

1 reference

Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

21 January 2018

1 reference

PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.

21 January 2018

1 reference

A small-molecule inducer of PDX1 expression identified by high-throughput screening.

21 January 2018

1 reference

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

21 January 2018

1 reference

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

31 March 2020

1 reference

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells

31 March 2020

1 reference

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection

31 March 2020

1 reference

Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice

31 March 2020

1 reference

The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro

31 March 2020

1 reference

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

31 March 2020

1 reference

Development and applications of single-cell transcriptome analysis

31 March 2020

1 reference

Metabolism of glucose in the islets of Langerhans

31 March 2020

1 reference

12 December 2020

Inhibitory effect of Artemisia capillaris extract on cytokine-induced nitric oxide formation and cytotoxicity of RINm5F cells

1 reference

12 December 2020

Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids

1 reference

12 December 2020

Radix asari extract protects pancreatic beta cells against cytokine-induced toxicity: implication of the NF-kappaB-iNOS signaling cascade.

1 reference

12 December 2020

Serotonin as marker for the secretory granules in the pancreatic beta-cell

1 reference

12 December 2020

Reprogramming of bone marrow-derived mesenchymal stem cells into functional insulin-producing cells by chemical regimen

1 reference

12 December 2020

In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation.

1 reference

12 December 2020

Purification and properties of human placental adenosine kinase

1 reference

12 December 2020

Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

1 reference

12 December 2020