Tetraspanin proteins promote multiple cancer stages (Q38186043)

30 August 2017

title

Tetraspanin proteins promote multiple cancer stages (English)

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30 August 2017

Martin E Hemler

1

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30 August 2017

language of work or name

English

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publication date

1 January 2014

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30 August 2017

published in

Nature Reviews Cancer

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30 August 2017

volume

14

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30 August 2017

issue

1

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30 August 2017

page(s)

49-60

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Lateral organization of membrane proteins: tetraspanins spin their web.

30 August 2017

cites work

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Tetraspanin functions and associated microdomains

31 March 2020

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Murine CD9 is the receptor for pregnancy-specific glycoprotein 17

31 March 2020

1 reference

Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression

31 March 2020

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Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

31 March 2020

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Functional interplay between tetraspanins and proteases

31 March 2020

1 reference

Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets

31 March 2020

1 reference

Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.

31 March 2020

1 reference

Tetraspanins: push and pull in suppressing and promoting metastasis

31 March 2020

1 reference

Tetraspanins in the immune response against cancer

31 March 2020

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Tetraspanins in human epithelial malignancies.

31 March 2020

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Tetraspanins and tumor progression

31 March 2020

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Targeting tetraspanins in cancer

31 March 2020

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Targeting of tetraspanin proteins--potential benefits and strategies

31 March 2020

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Tetraspanin CD151 as a target for antibody-based cancer immunotherapy

31 March 2020

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Prognostic significance of tetraspanin CD151 in newly diagnosed glioblastomas

31 March 2020

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Reduced CD151 expression is related to advanced tumour stage in urothelial bladder cancer

31 March 2020

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Application of RNA-Seq transcriptome analysis: CD151 is an Invasion/Migration target in all stages of epithelial ovarian cancer

31 March 2020

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Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin β1 complex in the progression of hepatocellular carcinoma

31 March 2020

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A specific gene expression signature characterizes metastatic potential in clear cell renal cell carcinoma.

31 March 2020

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Tetraspanin CD151 is a novel prognostic marker in poor outcome endometrial cancer

31 March 2020

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Clinical significance of CD151 overexpression in subtypes of invasive breast cancer

31 March 2020

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CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization

31 March 2020

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Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.

31 March 2020

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CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium.

31 March 2020

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The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth

31 March 2020

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The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.

31 March 2020

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Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.

31 March 2020

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Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis

31 March 2020

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Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications

31 March 2020

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An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology

31 March 2020

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Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins

31 March 2020

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Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly

31 March 2020

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CD151 restricts the α6 integrin diffusion mode

31 March 2020

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Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis

31 March 2020

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CD151 forms a functional complex with c-Met in human salivary gland cancer cells

31 March 2020

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CD151 regulates HGF-stimulated morphogenesis of human breast cancer cells.

31 March 2020

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STAT3 as a central mediator of neoplastic cellular transformation

31 March 2020

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Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis

31 March 2020

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Kidney failure in mice lacking the tetraspanin CD151.

31 March 2020

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Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane

31 March 2020

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Renal disease as a potential compounding factor in carcinogenesis experiments with Cd151-null mice.

31 March 2020

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Renal disease appears not to affect carcinogenesis in CD151-null mice.

31 March 2020

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Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

31 March 2020

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Cytometric and biochemical characterization of human breast cancer cells reveals heterogeneous myoepithelial phenotypes

31 March 2020

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Integrin alpha 6 regulates glioblastoma stem cells

31 March 2020

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Integrin α6(high) cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma

31 March 2020

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Genetic ablation of the tetraspanin CD151 reduces spontaneous metastatic spread of prostate cancer in the TRAMP model

31 March 2020

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ADAM10 as a target for anti-cancer therapy

31 March 2020

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Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

31 March 2020

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The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

31 March 2020

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TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

31 March 2020

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Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation

31 March 2020

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CD9 expression in gastric cancer and its significance

31 March 2020

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Prognostic significance of CD9 expression in locally advanced gastric cancer treated with surgery and adjuvant chemoradiotherapy

31 March 2020

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Upregulation of CD9 in ovarian cancer is related to the induction of TNF-α gene expression and constitutive NF-κB activation

31 March 2020

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Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia

31 March 2020

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Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro

31 March 2020

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Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.

31 March 2020

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Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization

31 March 2020

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The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration

31 March 2020

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Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo

31 March 2020

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CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase

31 March 2020

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Tetraspanin CD151 regulates transforming growth factor beta signaling: implication in tumor metastasis.

31 March 2020

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Diminished metastasis in tetraspanin CD151-knockout mice.

31 March 2020

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EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4.

31 March 2020

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Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model.

31 March 2020

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Targeting the transforming growth factor-beta signalling pathway in metastatic cancer

31 March 2020

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Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity

31 March 2020

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Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

31 March 2020

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Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma

31 March 2020

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Clinical significance of transmembrane 4 superfamily in colon cancer

31 March 2020

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Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer.

31 March 2020

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Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients

31 March 2020

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Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

31 March 2020

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Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization

31 March 2020

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Overexpression of tetraspanin CO-029 in hepatocellular carcinoma

31 March 2020

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Gene expression profiles of human melanoma cells with different invasive potential reveal TSPAN8 as a novel mediator of invasion.

31 March 2020

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Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility

31 March 2020

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Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy

31 March 2020

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Possible involvement of tetraspanin CO‐029 in hematogenous intrahepatic metastasis of liver cancer cells

31 March 2020

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Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation

31 March 2020

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Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029

31 March 2020

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Reduced body weight in male Tspan8-deficient mice

31 March 2020

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The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation

31 March 2020

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A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression

31 March 2020

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Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions

31 March 2020

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E-cadherin/p120-catenin and tetraspanin Co-029 cooperate for cell motility control in human colon carcinoma

31 March 2020

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Expression of Ep-CAM shifts the state of cadherin-mediated adhesions from strong to weak

31 March 2020

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A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9.

31 March 2020

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CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry

31 March 2020

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Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis

31 March 2020

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Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model

31 March 2020

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Regulatory role of tetraspanin CD9 in tumor-endothelial cell interaction during transendothelial invasion of melanoma cells

31 March 2020

2 references

31 March 2020

12 December 2020

Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation

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EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily

31 March 2020

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EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells

31 March 2020

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The major CD9 and CD81 molecular partner. Identification and characterization of the complexes

31 March 2020

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FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein

31 March 2020

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Profiling of the Tetraspanin Web of Human Colon Cancer Cells

31 March 2020

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Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

31 March 2020

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EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5

31 March 2020

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Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro

31 March 2020

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Assessment of myocardial blood perfusion improved by CD151 in a pig myocardial infarction model

31 March 2020

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Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension

31 March 2020

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Role of Akt signaling in vascular homeostasis and angiogenesis

31 March 2020

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Akt1 in endothelial cell and angiogenesis

31 March 2020

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Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by α3β1 versus α6β4 integrin

31 March 2020

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Role of tetraspanin CD151-α3/α6 integrin complex: Implication in angiogenesis CD151-integrin complex in angiogenesis.

31 March 2020

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Characterization of mice lacking the tetraspanin superfamily member CD151

31 March 2020

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Wound healing is defective in mice lacking tetraspanin CD151

31 March 2020

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Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy

31 March 2020

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Regional lymph node metastases, a singular manifestation of the process of clinical metastases in cancer: contemporary animal research and clinical reports suggest unifying concepts.

31 March 2020

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The tetraspanin CD9 inhibits the proliferation and tumorigenicity of human colon carcinoma cells.

31 March 2020

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Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes

31 March 2020

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A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies

31 March 2020

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Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical

31 March 2020

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Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals

31 March 2020

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Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor.

31 March 2020

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Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies

31 March 2020

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Probing the interaction of tetraspanin CD151 with integrin alpha 3 beta 1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha 3 beta 1 complex

31 March 2020

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CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin

31 March 2020

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A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo

31 March 2020

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A novel therapeutic strategy with anti-CD9 antibody in gastric cancers

31 March 2020

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CD9P-1 expression correlates with the metastatic status of lung cancer, and a truncated form of CD9P-1, GS-168AT2, inhibits in vivo tumour growth

31 March 2020

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A truncated form of CD9-partner 1 (CD9P-1), GS-168AT2, potently inhibits in vivo tumour-induced angiogenesis and tumour growth

31 March 2020

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TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling

31 March 2020

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Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists.

31 March 2020

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Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening

31 March 2020

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Cell fusion promotes chemoresistance in metastatic colon carcinoma

31 March 2020

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Dual targeting strategies with bispecific antibodies

31 March 2020

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Anti-idiotype x anti-CD44 bispecific antibodies inhibit invasion of lymphoid organs by B cell lymphoma

31 March 2020

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Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies.

31 March 2020

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Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges.

31 March 2020

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Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells.

31 March 2020

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Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells

31 March 2020

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Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81

31 March 2020

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Controlling cell surface dynamics and signaling: how CD82/KAI1 suppresses metastasis

31 March 2020

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CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts.

31 March 2020

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Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor

31 March 2020

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CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of β-catenin in carcinoma cells

31 March 2020

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A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells

31 March 2020

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The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

31 March 2020

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Normal viability of Kai1/Cd82 deficient mice.

31 March 2020

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Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151.

31 March 2020

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CD151 promotes cancer cell metastasis via integrins α3β1 and α6β1 in vitro

31 March 2020

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CD151 promotes proliferation and migration of PC3 cells via the formation of CD151-integrin α3/α6 complex

31 March 2020

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Tetraspanin CD151 regulates glycosylation of (alpha)3(beta)1 integrin.

31 March 2020

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A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5

31 March 2020

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Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151

31 March 2020

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Appearance of new tetraspanin genes during vertebrate evolution.

31 March 2020

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Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution.

31 March 2020

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Complete predicted three-dimensional structure of the facilitator transmembrane protein and hepatitis C virus receptor CD81: conserved and variable structural domains in the tetraspanin superfamily

31 March 2020

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CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

31 March 2020

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Functional domains in tetraspanin proteins

31 March 2020

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Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking

31 March 2020

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Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology

31 March 2020

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Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation

31 March 2020

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Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling

31 March 2020

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Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets.

31 March 2020

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Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surface

31 March 2020

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Significance of palmitoylation of CD81 on its association with tetraspanin-enriched microdomains and mediating hepatitis C virus cell entry

31 March 2020

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Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63.

31 March 2020

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The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization

31 March 2020

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DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151

31 March 2020

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The tetraspanin D6.1A and its molecular partners on rat carcinoma cells.

31 March 2020

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Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production

31 March 2020

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CD151 gene delivery increases eNOS activity and induces ECV304 migration, proliferation and tube formation

31 March 2020

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12 December 2020

The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice

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12 December 2020

Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions

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12 December 2020

Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo

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12 December 2020

CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: a new prognostic indicator?

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12 December 2020

Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma

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12 December 2020

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12 December 2020

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12 December 2020

Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells

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12 December 2020

Metastatic prostate cancer in a transgenic mouse

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12 December 2020

Signalling via integrins: implications for cell survival and anticancer strategies

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12 December 2020

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function

1 reference

12 December 2020

Progression of cervical carcinomas is associated with down-regulation of CD9 but strong local re-expression at sites of transendothelial invasion.

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12 December 2020

KAI-1/CD82, the molecule and clinical implication in cancer and cancer metastasis

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12 December 2020

Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis

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12 December 2020

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion

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12 December 2020

Expression and function of CD9 in melanoma cells

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12 December 2020

Identifiers

DOI

10.1038/NRC3640

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Dimensions Publication ID

30 August 2017

1022578524

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