Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities (Q38184343)

30 August 2017

title

Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities (English)

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30 August 2017

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30 August 2017

publication date

3 February 2014

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30 August 2017

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30 August 2017

volume

28

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30 August 2017

issue

7

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30 August 2017

page(s)

1414-1422

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Cell death in health and disease

30 August 2017

cites work

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Apoptosis-based therapies for hematologic malignancies

21 January 2018

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

21 January 2018

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Tumor resistance to apoptosis

21 January 2018

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Targeting IAP proteins for therapeutic intervention in cancer

21 January 2018

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Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

21 January 2018

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Targeting mitochondria for cancer therapy

21 January 2018

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Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

21 January 2018

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 January 2018

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Structural basis of caspase-7 inhibition by XIAP

21 January 2018

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Structural basis for the inhibition of caspase-3 by XIAP

21 January 2018

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

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Mechanism of XIAP-mediated inhibition of caspase-9

21 January 2018

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XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

21 January 2018

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Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis

21 January 2018

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X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

21 January 2018

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Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1

21 January 2018

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

21 January 2018

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Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

21 January 2018

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Livin, a novel inhibitor of apoptosis protein family member

21 January 2018

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ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

21 January 2018

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SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

21 January 2018

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Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

21 January 2018

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Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern

21 January 2018

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Survivin, cancer networks and pathway-directed drug discovery.

21 January 2018

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New wirings in the survivin networks

21 January 2018

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Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia

21 January 2018

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High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

21 January 2018

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Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups

21 January 2018

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Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

21 January 2018

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Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome.

21 January 2018

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Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia

21 January 2018

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XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL.

21 January 2018

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A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection

21 January 2018

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Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL).

21 January 2018

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Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes

21 January 2018

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Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia

21 January 2018

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Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies.

21 January 2018

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The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays.

21 January 2018

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Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia.

21 January 2018

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XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells

21 January 2018

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Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib.

21 January 2018

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Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment

21 January 2018

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A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

21 January 2018

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Characteristics of the caspase-like catalytic domain of human paracaspase.

21 January 2018

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 January 2018

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The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

21 January 2018

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Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

21 January 2018

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XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

21 January 2018

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Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas

21 January 2018

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

21 January 2018

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Design of small-molecule peptidic and nonpeptidic Smac mimetics

21 January 2018

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A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

21 January 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

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Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

21 January 2018

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Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

21 January 2018

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Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis

21 January 2018

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Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

21 January 2018

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Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

21 January 2018

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Smac mimetics: implications for enhancement of targeted therapies in leukemia

21 January 2018

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Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.

21 January 2018

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XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells

21 January 2018

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TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

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Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

21 January 2018

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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

21 January 2018

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RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

21 January 2018

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Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

21 January 2018

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Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

21 January 2018

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A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

21 January 2018

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Importance of genetics in chronic lymphocytic leukemia

21 January 2018

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Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

21 January 2018

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Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

21 January 2018

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CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.

21 January 2018

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Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

21 January 2018

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Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

21 January 2018

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XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34 38− cells in a phase 1/2 study of patients with relapsed/refractory AML

21 January 2018

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Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

21 January 2018

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Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

21 January 2018

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xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

21 January 2018

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12 December 2020

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias

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12 December 2020

Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis

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12 December 2020

Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma

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12 December 2020

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

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12 December 2020

The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas

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12 December 2020

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

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12 December 2020

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

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12 December 2020

Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

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12 December 2020

Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia

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12 December 2020

XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis

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12 December 2020

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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12 December 2020

Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18

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12 December 2020

Study of survivin and X-linked inhibitor of apoptosis protein (XIAP) genes in acute myeloid leukemia (AML)

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12 December 2020

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

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12 December 2020

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

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12 December 2020

Structural Basis of Caspase Inhibition by XIAP

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12 December 2020

Identifiers

DOI

10.1038/LEU.2014.56

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Dimensions Publication ID

30 August 2017

1035804358

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