Pros and cons of methods used for the prediction of oral drug absorption. (Q38177366)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

title

Pros and cons of methods used for the prediction of oral drug absorption (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

author name string

Nikoletta Fotaki

series ordinal

1

1 reference

30 August 2017

language of work or name

English

0 references

publication date

1 March 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

Expert Review of Clinical Pharmacology

4 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

page(s)

195-208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

ADMET in silico modelling: towards prediction paradise?

4 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Setting bioequivalence requirements for drug development based on preclinical data: optimizing oral drug delivery systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Computational models to predict aqueous drug solubility, permeability and intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

QSAR model for drug human oral bioavailability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In Silico ADME Prediction: Data, Models, Facts and Myths

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A 'rule of unity' for human intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Prediction of gastro-intestinal absorption using multivariate adaptive regression splines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

ADME evaluation in drug discovery. 8. The prediction of human intestinal absorption by a support vector machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

ADME evaluation in drug discovery. 7. Prediction of oral absorption by correlation and classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

ADME evaluation in drug discovery. 6. Can oral bioavailability in humans be effectively predicted by simple molecular property-based rules?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Guidance in the setting of drug particle size specifications to minimize variability in absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Applications of physiologically based absorption models in drug discovery and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: a mathematical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Quantitative biopharmaceutics classification system: the central role of dose/solubility ratio.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Evaluation and suggested improvements of the Biopharmaceutics Classification System (BCS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Use of the Biopharmaceutical Classification System in early drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Recent advances in computational prediction of drug absorption and permeability in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

QSAR analysis of membrane permeability to organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Membrane transport of drugs in different regions of the intestinal tract of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Caco-2 monolayers in experimental and theoretical predictions of drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A physiological model for the estimation of the fraction dose absorbed in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Exploring the role of different drug transport routes in permeability screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Predicting passive transport in silico--history, hype, hope

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In vitro studies are sometimes better than conventional human pharmacokinetic in vivo studies in assessing bioequivalence of immediate-release solid oral dosage forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Human intestinal permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Assessing the absorption of new pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

An in vitro system for prediction of oral absorption of relatively water-soluble drugs and ester prodrugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Transport of bile acids in a human intestinal epithelial cell line, Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Cell culture-based models for intestinal permeability: a critique

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Development and evaluation of an in vitro method for prediction of human drug absorption II. Demonstration of the method suitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Physiologically-based pharmacokinetic simulation modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

D-cycloserine uses an active transport mechanism in the human intestinal cell line Caco 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Current industrial practices of assessing permeability and P-glycoprotein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Prediction of human pharmacokinetics--gastrointestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Biorelevant dissolution media as a predictive tool for glyburide a class II drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Companion animal physiology and dosage form performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Comparison of oral absorption and bioavailablity of drugs between monkey and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Comparison between permeability coefficients in rat and human jejunum

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Evaluation of rat intestinal absorption data and correlation with human intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Asymmetric intestinal first-pass metabolism causes minimal oral bioavailability of midazolam in cynomolgus monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Characteristics of the gastric pH profiles of unfed and fed cynomolgus monkeys as pharmaceutical product development subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Comparison of canine and human gastrointestinal physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A compartmental absorption and transit model for estimating oral drug absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

A physiologic model for simulating gastrointestinal flow and drug absorption in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

General solution for diffusion-controlled dissolution of spherical particles. 1. Theory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Drug absorption modeling as a tool to define the strategy in clinical formulation development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Pharmacometrics: modelling and simulation tools to improve decision making in clinical drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Biomarkers, validation and pharmacokinetic-pharmacodynamic modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Whole-body physiologically based pharmacokinetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Application of in silico approaches to predicting drug--drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In vitro tests for predicting drug-drug interactions: the need for validated procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Multivariate pharmaceutical profiling for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

In silico approaches for predicting ADME properties of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Improving early drug discovery through ADME modelling: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Applications of high-throughput ADME in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Predicting ADME properties in silico: methods and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Future directions for drug transporter modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Role of transport proteins in drug absorption, distribution and excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Modeling of active transport systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

The human intestinal cytochrome P450 "pie".

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Prediction of intestinal first-pass drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Pharmacokinetic strategies in deciphering atypical drug absorption profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Investigating the utility of momentum-space descriptors for predicting blood-brain barrier penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

3D QSAR investigation of the blood-brain barrier penetration of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Development of reliable aqueous solubility models and their application in druglike analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Towards quantitative prediction of oral drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

Theoretical dissolution model of poly-disperse drug particles in biorelevant media.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/17512433.2.2.195

ADME evaluation in drug discovery. 4. Prediction of aqueous solubility based on atom contribution approach.

21 January 2018

1 reference

7 December 2024

https://opencitations.net/index/api/v1/citations/10.1021/CI034184N

Identifiers

DOI

10.1586/17512433.2.2.195

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24410651 AND SRC:MED&resulttype=core&format=json

4 March 2020

1 reference