Immune modulation by multifaceted cationic host defense (antimicrobial) peptides (Q38162670)

30 August 2017

title

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides (English)

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30 August 2017

3

Robert E W Hancock

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30 August 2017

Ashley L Hilchie

1

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30 August 2017

Kelli Wuerth

series ordinal

2

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30 August 2017

publication date

1 December 2013

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30 August 2017

published in

Nature Chemical Biology

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30 August 2017

volume

9

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30 August 2017

issue

12

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30 August 2017

page(s)

761-768

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Therapeutic potential of host defense peptides in antibiotic-resistant infections

30 August 2017

cites work

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AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

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Innate antimicrobial peptide protects the skin from invasive bacterial infection

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The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

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A comprehensive summary of LL-37, the factotum human cathelicidin peptide.

21 January 2018

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Endogenous antimicrobial peptide LL-37 induces human vasodilatation.

21 January 2018

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An anti-infective peptide that selectively modulates the innate immune response

21 January 2018

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Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency

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Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.

21 January 2018

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Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment

21 January 2018

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Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation

21 January 2018

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Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models

21 January 2018

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Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin.

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Intracellular receptor for human host defense peptide LL-37 in monocytes

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Enabling a systems biology approach to immunology: focus on innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Structural studies of a peptide with immune modulating and direct antimicrobial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells

21 January 2018

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https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Innate defense regulator peptide 1018 in wound healing and wound infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Immunomodulators as adjuvants for vaccines and antimicrobial therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The perfect mix: recent progress in adjuvant research

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

beta-Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Immunity to Bordetella pertussis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

21 January 2018

Cutaneous wound healing

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Bacteria and wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Host defense peptides in wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

HB-107, a nonbacteriostatic fragment of the antimicrobial peptide cecropin B, accelerates murine wound repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Host defence peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-kappaB signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Nonviral human beta defensin-3 expression in a bioengineered human skin tissue: a therapeutic alternative for infected wounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The design, synthesis and application of stereochemical and directional peptide isomers: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

The co-evolution of host cationic antimicrobial peptides and microbial resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin-6 response in human monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Bovine lactoferricin inhibits basic fibroblast growth factor- and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Impact of LL-37 on anti-infective immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

LL-37 protects rats against lethal sepsis caused by gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFR (J6-1) DNA vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

Wound healing activity of the human antimicrobial peptide LL37

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1393

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

21 January 2018

1 reference

12 December 2020

Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines

1 reference

12 December 2020

The 10(5) bacterial growth guideline: reassessing its clinical relevance in wound healing.

1 reference

12 December 2020

Immune dysfunction in patients with diabetes mellitus (DM).

1 reference

12 December 2020

Designing antimicrobial peptides: form follows function.

1 reference

12 December 2020

Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens

1 reference

12 December 2020

The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes

1 reference

12 December 2020

New insights into cathelicidin modulation of adaptive immunity

1 reference

12 December 2020

The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization

1 reference

12 December 2020

Signalling of toll-like receptors.

1 reference

12 December 2020

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations

1 reference

12 December 2020

PR39, a peptide regulator of angiogenesis

1 reference

12 December 2020

Host defense peptides for use as potential therapeutics.

1 reference

12 December 2020

Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections

1 reference

12 December 2020

LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1393

1 reference

30 August 2017

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