The role of hypoxia in stem cell potency and differentiation (Q38154615)

29 August 2017

title

The role of hypoxia in stem cell potency and differentiation (English)

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29 August 2017

Kate E Hawkins

1

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29 August 2017

Tyson V Sharp

series ordinal

2

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29 August 2017

Tristan R McKay

series ordinal

3

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29 August 2017

publication date

1 November 2013

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29 August 2017

published in

Regenerative Medicine

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29 August 2017

volume

8

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29 August 2017

issue

6

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29 August 2017

page(s)

771-782

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Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia

29 August 2017

cites work

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

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Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

21 January 2018

1 reference

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

21 January 2018

1 reference

The impact of O2 availability on human cancer

21 January 2018

1 reference

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

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Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

21 January 2018

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Oxygen in the cultivation of stem cells

21 January 2018

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Cord blood-derived CD34 hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function.

21 January 2018

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

21 January 2018

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

21 January 2018

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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

21 January 2018

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ARNT-deficient mice and placental differentiation

21 January 2018

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

21 January 2018

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

21 January 2018

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Molecular control of pluripotency

21 January 2018

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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

21 January 2018

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

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Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.

21 January 2018

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Low O2 tensions and the prevention of differentiation of hES cells

21 January 2018

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Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts

21 January 2018

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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells

21 January 2018

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A reduced oxygen tension (5%) is not beneficial for maintaining human embryonic stem cells in the undifferentiated state with short splitting intervals

21 January 2018

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Self-renewal and pluripotency is maintained in human embryonic stem cells by co-culture with human fetal liver stromal cells expressing hypoxia inducible factor 1alpha

21 January 2018

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HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

21 January 2018

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FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.

21 January 2018

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Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

21 January 2018

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The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

21 January 2018

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Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.

21 January 2018

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Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia.

21 January 2018

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LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells

21 January 2018

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Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

21 January 2018

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Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia

21 January 2018

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Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF.

21 January 2018

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Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor

21 January 2018

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Hypoxia enhances the generation of retinal progenitor cells from human induced pluripotent and embryonic stem cells.

21 January 2018

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Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality

21 January 2018

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Hypoxia-driven proliferation of embryonic neural stem/progenitor cells--role of hypoxia-inducible transcription factor-1alpha

21 January 2018

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Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning

21 January 2018

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Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha

21 January 2018

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Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases

21 January 2018

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Identification of the haematopoietic stem cell niche and control of the niche size

21 January 2018

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Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

21 January 2018

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Long-term repopulating hematopoietic stem cells and "side population" in human steady state peripheral blood

21 January 2018

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The hematopoietic stem cell niche: low in oxygen but a nice place to be.

21 January 2018

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Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

21 January 2018

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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

21 January 2018

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Redox regulation of stem cell mobilization

21 January 2018

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Very low O2 concentration (0.1%) favors G0 return of dividing CD34 cells.

21 January 2018

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Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow

21 January 2018

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The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

21 January 2018

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Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.

21 January 2018

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HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

21 January 2018

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Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells

21 January 2018

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Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.

21 January 2018

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Functional stability (at 4°C) of hematopoietic stem and progenitor cells amplified ex vivo from cord blood CD34 cells

21 January 2018

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Clinical-scale cultures of cord blood CD34( ) cells to amplify committed progenitors and maintain stem cell activity.

21 January 2018

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Marrow stromal cells as stem cells for nonhematopoietic tissues

21 January 2018

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Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

21 January 2018

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Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia

21 January 2018

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Mesenchymal stem cells and their potential as cardiac therapeutics

21 January 2018

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Stem cell therapy in cardiology

21 January 2018

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Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells

21 January 2018

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Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

21 January 2018

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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

21 January 2018

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Transcriptional profiling of human cord blood CD133 and cultured bone marrow mesenchymal stem cells in response to hypoxia

21 January 2018

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Survival and function of mesenchymal stem cells (MSCs) depend on glucose to overcome exposure to long-term, severe and continuous hypoxia

21 January 2018

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Role of HIF-1alpha and VEGF in human mesenchymal stem cell proliferation by 17beta-estradiol: involvement of PKC, PI3K/Akt, and MAPKs

21 January 2018

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Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells.

21 January 2018

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Autocrine fibroblast growth factor 2-mediated interactions between human mesenchymal stem cells and the extracellular matrix under varying oxygen tension

21 January 2018

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HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.

21 January 2018

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Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha

21 January 2018

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Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells

21 January 2018

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Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering

21 January 2018

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Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions.

21 January 2018

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Hypoxia inhibits the differentiation of mesenchymal stem cells into osteoblasts by activation of Notch signaling

21 January 2018

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Oxygenated environment enhances both stem cell survival and osteogenic differentiation

21 January 2018

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Tissue oxygen tension and brain sensitivity to hypoxia

21 January 2018

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Astrocytic stem cells in the adult brain

21 January 2018

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A specialized vascular niche for adult neural stem cells.

21 January 2018

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

21 January 2018

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The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy.

21 January 2018

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Hypoxia-Inducible Factors and the Response to Hypoxic Stress

21 January 2018

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Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia

21 January 2018

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TLX controls angiogenesis through interaction with the von Hippel-Lindau protein

21 January 2018

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Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling

21 January 2018

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Hypoxia requires notch signaling to maintain the undifferentiated cell state

21 January 2018

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

21 January 2018

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O2 regulates stem cells through Wnt/β-catenin signalling.

21 January 2018

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Hypoxia/reoxygenation stimulates proliferation through PKC-dependent activation of ERK and Akt in mouse neural progenitor cells

21 January 2018

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Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro

21 January 2018

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Mild hypoxia enhances proliferation and multipotency of human neural stem cells

21 January 2018

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Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism

21 January 2018

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Current challenges for the advancement of neural stem cell biology and transplantation research.

21 January 2018

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Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection

21 January 2018

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Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/RME.13.71

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29 August 2017

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