Zinc and insulin in pancreatic beta-cells (Q38131728)

29 August 2017

title

Zinc and insulin in pancreatic beta-cells (English)

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29 August 2017

Yang V Li

1

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29 August 2017

language of work or name

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24 August 2013

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29 August 2017

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29 August 2017

volume

45

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29 August 2017

issue

2

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29 August 2017

page(s)

178-189

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THE INSULIN AND THE ZINC CONTENT OF NORMAL AND DIABETIC PANCREAS.

29 August 2017

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Zinc-ligand interactions modulate assembly and stability of the insulin hexamer -- a review

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A brief perspective on insulin production

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Kinetic aspects of compartmental storage and secretion of insulin and zinc

21 January 2018

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Relationship Between Insulin Release and 65Zinc Efflux from Rat Pancreatic Islets Maintained in Tissue Culture

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Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis

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Mammalian zinc transport, trafficking, and signals

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Zinc transporters and the cellular trafficking of zinc

21 January 2018

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Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc

21 January 2018

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Elemental composition of secretory granules in pancreatic islets of Langerhans

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Zinc-buffering capacity of a eukaryotic cell at physiological pZn.

21 January 2018

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Transient fluctuations of intracellular zinc ions in cell proliferation

21 January 2018

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Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells

21 January 2018

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Zinc and redox signaling: perturbations associated with cardiovascular disease and diabetes mellitus

21 January 2018

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Functional significance of zinc-related signaling pathways in immune cells.

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Zinc in the physiology and pathology of the CNS.

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Rising intracellular zinc by membrane depolarization and glucose in insulin-secreting clonal HIT-T15 beta cells

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Eukaryotic zinc transporters and their regulation

21 January 2018

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The neurobiology of zinc in health and disease

21 January 2018

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Plasticity of mitochondrial calcium signaling

21 January 2018

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Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zn(2 ) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae

21 January 2018

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Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells

21 January 2018

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Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Heteromeric protein complexes mediate zinc transport into the secretory pathway of eukaryotic cells

21 January 2018

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https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc

21 January 2018

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https://api.crossref.org/works/10.1007/S12020-013-0032-X

Metallothionein as an adaptive protein prevents diabetes and its toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Metallothionein induction in islets of Langerhans and insulinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Essentiality, toxicology and chelation therapy of zinc and copper

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Oxidative stress and brain aging: is zinc the link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Clinical, immunological, anti-inflammatory and antioxidant roles of zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The role of zinc in caspase activation and apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc: health effects and research priorities for the 1990s

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Identification and characterization of zinc binding sites in protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc inhibition of calmodulin: A proposed molecular mechanism of zinc action on cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Effect of zinc on calmodulin-stimulated protein kinase II and protein phosphorylation in rat cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Overview of mammalian zinc transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Mechanisms of mammalian zinc-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Mammalian zinc transporters: nutritional and physiologic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Kinetic study of the antiport mechanism of an Escherichia coli zinc transporter, ZitB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

An antiport mechanism for a member of the cation diffusion facilitator family: divalent cations efflux in exchange for K and H .

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Characterization of the ZAT1p zinc transporter from Arabidopsis thaliana in microbial model organisms and reconstituted proteoliposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

ZnT-3, a putative transporter of zinc into synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Localization of zip1 and zip4 mRNA in the adult rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Investigation of transport mechanisms and regulation of intracellular Zn2 in pancreatic alpha-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zn2 transporters and Zn2 homeostasis in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc: new clues to diverse roles in brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Mechanisms of Zn2 efflux in cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The Zn2 -transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2 channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc, a regulator of islet function and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Think zinc: New roles for zinc in the control of insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Metabolic coupling factors in pancreatic beta-cell signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Metabolic regulation of the pancreatic beta-cell ATP-sensitive K channel: a pas de deux

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Calcium currents in insulin-secreting beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Regulation of resident and newcomer insulin granules by calcium and SNARE proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

A role for zinc in pancreatic islet β‐cell cross‐talk with the α‐cell during hypoglycaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The Mechanism of Zinc Uptake in Isolated Islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Insulin receptor signaling and sarco/endoplasmic reticulum calcium ATPase in beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Autocrine regulation of insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Current views on type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Regulation of insulin secretion: role of mitochondrial signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Hyperglycaemia but not hyperlipidaemia causes beta cell dysfunction and beta cell loss in the domestic cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Membrane ion channels and diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc and Zinc Transporter Regulation in Pancreatic Islets and the Potential Role of Zinc in Islet Transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Voltage-dependent Na and Ca2 currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc-induced changes in ionic currents of clonal rat pancreatic -cells: activation of ATP-sensitive K channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

GPR39: a Zn2 -activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The effects of environmental lead exposure and in vitro zinc on tissue δ-aminolevulinic acid dehydratase in urban pigeons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Kinetic and quantitative relationships between insulin release and 65Zn efflux from perifused islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc-induced changes in ionic currents of cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Inhibitory effect of zinc on glucose-stimulated zinc/insulin secretion in an insulin-secreting β-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Insulin reciprocally regulates glucagon secretion in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

ATP-sensitive K channel mediates the zinc switch-off signal for glucagon response during glucose deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc is both an intracellular and extracellular regulator of KATP channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Renal handling of zinc in insulin-dependent diabetes mellitus patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

Zinc, insulin and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12020-013-0032-X

The discovery of insulin: the inside story

21 January 2018

1 reference

12 December 2020

The Crystal Structure of Rhombohedral 2 Zinc Insulin

1 reference

12 December 2020

Metallothionein in pancreatic endocrine neoplasms

1 reference

12 December 2020

The regulatory domain of protein kinase C coordinates four atoms of zinc

1 reference

12 December 2020

Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts

1 reference

12 December 2020

Editorial: Errors in insulin biosynthesis

1 reference

12 December 2020

Single Calcium Channel Activity in Mouse Pancreatic ?-Cells

1 reference

12 December 2020

The zinc sensing receptor, a link between zinc and cell signaling

1 reference

12 December 2020

Hyperzincuria in individuals with insulin-dependent diabetes mellitus: concurrent zinc status and the effect of high-dose zinc supplementation

1 reference

12 December 2020

Expression and role of ionotropic glutamate receptors in pancreatic islet cells

1 reference

12 December 2020

Regulation of Zinc Metabolism and Genomic Outcomes

1 reference

12 December 2020

Do We Need Zinc to Think?

1 reference

12 December 2020

The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.

1 reference

12 December 2020

Banting's, Best's, and Collip's accounts of the discovery of insulin.

1 reference

12 December 2020

The biochemical basis of zinc physiology

1 reference

12 December 2020

Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death

1 reference

12 December 2020

Zinc-induced inhibition of insulin secretion from isolated rat islets of Langerhans

1 reference

12 December 2020

Pancreatic beta-cells secrete insulin in fast- and slow-release forms

1 reference

12 December 2020

Chemical and biological aspects of insulin and proinsulin

1 reference

12 December 2020

Abnormal zinc metabolism in type II diabetes mellitus

1 reference

12 December 2020

Metal ions induce expression of metallothionein in pancreatic exocrine and endocrine cells

1 reference

12 December 2020

Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice

1 reference

12 December 2020

Conformational changes induced by binding of divalent cations to calregulin

1 reference

12 December 2020

Importance of zinc in the central nervous system: the zinc-containing neuron

1 reference

12 December 2020

The internal secretion of the pancreas. 1922

1 reference

12 December 2020

Rapid translocation of Zn(2 ) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation

1 reference

12 December 2020

Protective effects of metallothionein on streptozotocin-induced diabetes in rats

1 reference

12 December 2020

Kinetics of 65zinc uptake and distribution in fractions from cultured rat islets of langerhans

1 reference

12 December 2020

Identification of the Zn2 binding region in calreticulin

1 reference

12 December 2020

Molecular biology of adenosine triphosphate-sensitive potassium channels

1 reference

12 December 2020

X-ray structure of an unusual calcium site and the roles of zinc and calcium in the assembly, stability, and storage of the insulin hexamer

1 reference

12 December 2020

Three-dimensional atomic structure of insulin and its relationship to activity

1 reference

12 December 2020

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo

1 reference

12 December 2020

Evidence for a zinc/proton antiporter in rat brain

1 reference

12 December 2020

Comparison of the zinc binding domains in the 7S nerve growth factor and the zinc-insulin hexamer

1 reference

12 December 2020

Effects of Zn2 on glucose-induced electrical activity and insulin release from mouse pancreatic islets

1 reference

12 December 2020

Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice

1 reference

12 December 2020

Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum

1 reference

12 December 2020

Modulation of the phosphorylation and activity of calcium/calmodulin-dependent protein kinase II by zinc

1 reference

12 December 2020

Increased pancreatic metallothionein and glutathione levels: protecting against cerulein- and taurocholate-induced acute pancreatitis in rats

1 reference

12 December 2020

The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain

1 reference

12 December 2020

10.1007/S12020-013-0032-X

Identifiers

DOI

1 reference

29 August 2017

1 reference