The role of FOXO1 in β-cell failure and type 2 diabetes mellitus (Q38130126)

29 August 2017

title

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus (English)

1 reference

29 August 2017

0 references

Tadahiro Kitamura

1

1 reference

29 August 2017

publication date

20 August 2013

1 reference

Nature Reviews Endocrinology

29 August 2017

published in

1 reference

29 August 2017

volume

9

1 reference

29 August 2017

issue

10

1 reference

29 August 2017

page(s)

615-623

1 reference

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Nutrition-/diet-induced changes in gene expression in pancreatic β-cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Disruption of IRS-2 causes type 2 diabetes in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Regulation of FoxO transcription factors by acetylation and protein-protein interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The forkhead transcription factor Foxo1 regulates adipocyte differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Cellular survival: a play in three Akts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Mammalian SIRT1 represses forkhead transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Pancreatic beta-cell mass in European subjects with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Endoplasmic reticulum stress and type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

31 March 2020

What ails the β-cell?

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Oxygen microsensor and its application to single cells and mouse pancreatic islets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Increased number of islet-associated macrophages in type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The replication of beta cells in normal physiology, in disease and for therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

beta-Cell death during progression to diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Early development of beta-cells is impaired in the GK rat model of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Autophagy: process and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Role of autophagy in β-cell function and mass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Autophagic programmed cell death by selective catalase degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Autophagy is activated for cell survival after endoplasmic reticulum stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Endoplasmic reticulum stress triggers autophagy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Autophagy in human type 2 diabetes pancreatic beta cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Membrane interaction of islet amyloid polypeptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Promotion of direct reprogramming by transformation-deficient Myc.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Opposing actions of Arx and Pax4 in endocrine pancreas development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Role of FoxO Proteins in Pancreatic beta Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

FoxO1 gain of function in the pancreas causes glucose intolerance, polycystic pancreas, and islet hypervascularization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

FOXO1 in the ventromedial hypothalamus regulates energy balance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Essential role of endothelial Notch1 in angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Functional and molecular defects of pancreatic islets in human type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Notch signalling controls pancreatic cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRENDO.2013.157

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

31 March 2020

1 reference

12 December 2020

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1 reference

12 December 2020

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus

1 reference

12 December 2020

Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects.

1 reference

12 December 2020

Notch signaling is essential for vascular morphogenesis in mice

1 reference

12 December 2020

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2013.157

1 reference

Dimensions Publication ID

29 August 2017

1007681653

0 references

1 reference