Atypical aging in Down syndrome (Q38129325)

29 August 2017

title

Atypical aging in Down syndrome (English)

1 reference

29 August 2017

Warren B Zigman

1

1 reference

29 August 2017

publication date

1 January 2013

1 reference

Developmental Disabilities Research Reviews

29 August 2017

published in

1 reference

29 August 2017

volume

18

1 reference

29 August 2017

issue

1

1 reference

29 August 2017

page(s)

51-67

1 reference

An association study of common variation at the MAPT locus with late-onset Alzheimer's disease

29 August 2017

cites work

1 reference

Cervical spine abnormalities associated with Down syndrome

21 January 2018

1 reference

Bone mineral density in adults with Down's syndrome

21 January 2018

1 reference

Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs

21 January 2018

1 reference

Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study

21 January 2018

1 reference

Aging and Down syndrome: implications for physical therapy

21 January 2018

1 reference

Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

21 January 2018

1 reference

Epidemiologic study of Down syndrome in a racially diverse California population, 1989-1991.

21 January 2018

1 reference

The four ages of Down syndrome

21 January 2018

1 reference

Nutritional status and risk factors for chronic disease in urban-dwelling adults with Down syndrome

21 January 2018

1 reference

The endoplasmic reticulum stress response in aging and age-related diseases

21 January 2018

1 reference

Evidence for accelerated skin wrinkling among developmentally delayed individuals with Down's syndrome

21 January 2018

1 reference

Early onset of presbyacusis in Down syndrome

21 January 2018

1 reference

Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis

21 January 2018

1 reference

Cellular ageing of Alzheimer's disease and down syndrome cells in culture

21 January 2018

1 reference

Menopause in women with learning disabilities.

21 January 2018

1 reference

DNA damage, cellular senescence and organismal ageing: causal or correlative?

21 January 2018

1 reference

Prevalence of cataract and pseudophakia/aphakia among adults in the United States

21 January 2018

1 reference

Dementia and mortality in persons with Down's syndrome

21 January 2018

1 reference

Survival in elderly persons with Down syndrome

21 January 2018

1 reference

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

Mucocutaneous findings in 100 children with Down syndrome

21 January 2018

1 reference

Metabolic syndrome in 25% of older people with intellectual disability

21 January 2018

1 reference

APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.

21 January 2018

1 reference

21 January 2018

1 reference

Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial

21 January 2018

1 reference

Preparing primary care for the future - perspectives from the Netherlands, England, and USA.

21 January 2018

1 reference

Health Conditions Associated with Aging and End of Life of Adults with Down Syndrome

21 January 2018

1 reference

Prevalence of visual and hearing impairment in a Dutch institutionalized population with intellectual disability

21 January 2018

1 reference

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

1 reference

The epigenetics of cancer etiology

21 January 2018

1 reference

Insulin resistance in adolescents with Down syndrome: a cross-sectional study

21 January 2018

1 reference

Prevalence and clinical outcome of mitral-valve prolapse.

21 January 2018

1 reference

Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database

21 January 2018

1 reference

Determining the amount, timing and causes of mortality among infants with Down syndrome

21 January 2018

1 reference

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

21 January 2018

1 reference

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

21 January 2018

1 reference

Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults

21 January 2018

1 reference

Epigenetics, Copy Number Variation, and Other Molecular Mechanisms Underlying Neurodevelopmental Disabilities: New Insights and Diagnostic Approaches

21 January 2018

1 reference

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.

21 January 2018

1 reference

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

The scientific activities of Alexander Fleming, other than the discovery of penicillin

21 January 2018

1 reference

Aging: a theory based on free radical and radiation chemistry

21 January 2018

1 reference

Endocrine and musculoskeletal abnormalities in patients with Down syndrome

21 January 2018

1 reference

Ten-year survival of Down syndrome births.

21 January 2018

1 reference

Incidence and course of dementia in people with Down's syndrome: findings from a population-based study

21 January 2018

1 reference

Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome.

21 January 2018

1 reference

Aging effects on DNA methylation modules in human brain and blood tissue

21 January 2018

1 reference

Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.

21 January 2018

1 reference

Mechanisms of tau-induced neurodegeneration

21 January 2018

1 reference

Twenty-year trends in prevalence and survival of Down syndrome

21 January 2018

1 reference

Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease.

21 January 2018

1 reference

Apolipoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease

21 January 2018

1 reference

Prevalence of dementia and impact on intellectual disability services.

21 January 2018

1 reference

Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia.

21 January 2018

1 reference

Shorter telomeres may indicate dementia status in older individuals with Down syndrome.

21 January 2018

1 reference

Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns

21 January 2018

1 reference

Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.

21 January 2018

1 reference

Prevalence of chronic medical conditions in adults with mental retardation: comparison with the general population

21 January 2018

1 reference

Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity

21 January 2018

1 reference

Altered DNA methylation in leukocytes with trisomy 21

21 January 2018

1 reference

Genetic and epigenetic dysregulation of imprinted genes in the brain

21 January 2018

1 reference

What is a cohort effect? Comparison of three statistical methods for modeling cohort effects in obesity prevalence in the United States, 1971-2006

21 January 2018

1 reference

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

21 January 2018

1 reference

Successful aging in a 70-year-old man with down syndrome: a case study

21 January 2018

1 reference

APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome

21 January 2018

1 reference

Decreased AIRE expression and global thymic hypofunction in Down syndrome.

21 January 2018

1 reference

Down's syndrome, aging, and Alzheimer's disease: a clinical review

21 January 2018

1 reference

Antioxidants in Down syndrome

21 January 2018

1 reference

Neurological phenotypes for Down syndrome across the life span

21 January 2018

1 reference

Down syndrome and Alzheimer's disease: a link between development and aging

21 January 2018

1 reference

Alzheimer disease and Down syndrome: factors in pathogenesis

21 January 2018

1 reference

Dementia in Down's syndrome: Observations from a neurology clinic

21 January 2018

1 reference

Healthcare and guidelines: a population-based survey of recorded medical problems and health surveillance for people with Down syndrome

21 January 2018

1 reference

Cytogenetic analysis of 1572 cases of Down syndrome: a report of double aneuploidy and novel findings 47,XY, t(14;21)(q13;q22.3)mat, 21 and 45,XX,t(14;21) in an Indian population

21 January 2018

1 reference

Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes

21 January 2018

1 reference

The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease

21 January 2018

1 reference

The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

21 January 2018

1 reference

Indicators of amyloid burden in a population-based study of cognitively normal elderly

21 January 2018

1 reference

Down syndrome: orthopedic issues.

21 January 2018

1 reference

Low blood pressure in Down's syndrome, A link with Alzheimer's disease?

21 January 2018

1 reference

Down's syndrome: an atheroma-free model?

21 January 2018

1 reference

Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment

21 January 2018

1 reference

Learning and memory as a function of age in Down syndrome: a study using animal-based tasks

21 January 2018

1 reference

A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

21 January 2018

1 reference

Effect of menopause on cognitive performance in women with Down syndrome.

21 January 2018

1 reference

Molecular genetic analysis of Down syndrome

21 January 2018

1 reference

The relative effects of paternal and maternal age in mongolism. 1933.

21 January 2018

1 reference

Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome

21 January 2018

1 reference

Protective actions of sex steroid hormones in Alzheimer's disease

21 January 2018

1 reference

Metabolic implications of menopause

21 January 2018

1 reference

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

21 January 2018

1 reference

Natural history of thyroid function in adults with Down syndrome--10-year follow-up study

21 January 2018

1 reference

Fifteen-year follow-up of thyroid status in adults with Down syndrome

21 January 2018

1 reference

Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population

21 January 2018

1 reference

Long term safety and efficacy of donepezil in the treatment of dementia in Alzheimer's disease in adults with Down syndrome: open label study

21 January 2018

1 reference

Total serum cholesterol levels and Alzheimer's dementia in patients with Down syndrome

21 January 2018

1 reference

ApoE Genotype and Alzheimer's Disease in Adults With Down Syndrome: Meta-Analysis

21 January 2018

1 reference

Molecular mapping of Alzheimer-type dementia in Down's syndrome

21 January 2018

1 reference

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease--pilot study.

21 January 2018

1 reference

Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome

21 January 2018

1 reference

Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndrome

21 January 2018

1 reference

Infections and immunodeficiency in Down syndrome

21 January 2018

1 reference

Predictors of survival in children born with Down syndrome: a registry-based study

21 January 2018

1 reference

Twenty-first century vaccines

21 January 2018

1 reference

Epidemiology of Alzheimer disease

21 January 2018

1 reference

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome

21 January 2018

1 reference

Stiffness of the large arteries in individuals with and without Down syndrome

21 January 2018

1 reference

21 January 2018

1 reference

Understanding the basis for Down syndrome phenotypes

21 January 2018

1 reference

Apo E genotypes and risk of dementia in Down syndrome.

21 January 2018

1 reference

Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

21 January 2018

1 reference

Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.

21 January 2018

1 reference

Genetic and host factors for dementia in Down's syndrome

21 January 2018

1 reference

Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.

21 January 2018

1 reference

Earlier onset of Alzheimer's disease in men with Down syndrome

21 January 2018

1 reference

Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

21 January 2018

1 reference

Onset of dementia is associated with age at menopause in women with Down's syndrome

21 January 2018

1 reference

Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome

21 January 2018

1 reference

Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome

21 January 2018

1 reference

Change in plasma Aß peptides and onset of dementia in adults with Down syndrome

21 January 2018

1 reference

Normal and abnormal biology of the beta-amyloid precursor protein

21 January 2018

1 reference

Oxidative damage, ageing, and life-history evolution: where now?

21 January 2018

1 reference

Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes

21 January 2018

1 reference

Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations

21 January 2018

1 reference

Prevalence of Down syndrome among children and adolescents in 10 regions of the United States

21 January 2018

1 reference

Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study

21 January 2018

1 reference

Down syndrome: cognitive phenotype

21 January 2018

1 reference

Osteoporosis in people with intellectual disabilities: a review and a brief study of risk factors for osteoporosis in a community sample of people with intellectual disabilities

21 January 2018

1 reference

Developmental disabilities grown up: Down syndrome

21 January 2018

1 reference

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

21 January 2018

1 reference

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

21 January 2018

1 reference

The pattern and profile of alopecia areata in Singapore--a study of 219 Asians

21 January 2018

1 reference

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

21 January 2018

1 reference

Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region

21 January 2018

1 reference

2011 Alzheimer's disease facts and figures

21 January 2018

1 reference

Inflammatory and Immunological parameters in adults with Down syndrome

21 January 2018

1 reference

Maladaptive behaviors related to adaptive decline in aging adults with mental retardation

21 January 2018

1 reference

Psychiatric symptoms in adults with Down syndrome and Alzheimer's disease.

21 January 2018

1 reference

Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study

21 January 2018

1 reference

Epigenetics in cancer: implications for early detection and prevention

21 January 2018

1 reference

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

21 January 2018

1 reference

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

21 January 2018

1 reference

Twenty‐Five–Year survival of children with birth defects in New York State: A population‐based study

21 January 2018

1 reference

The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception.

21 January 2018

1 reference

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

21 January 2018

1 reference

Estrogen therapy in postmenopausal women: effects on cognitive function and dementia

21 January 2018

1 reference

The metabolic syndrome and development of cognitive impairment among older women

21 January 2018

1 reference

Abeta42 is more rigid than Abeta40 at the C terminus: implications for Abeta aggregation and toxicity

21 January 2018

1 reference

Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome

21 January 2018

1 reference

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

21 January 2018

1 reference

Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study.

21 January 2018

1 reference

Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.

21 January 2018

1 reference

Survival among people with Down syndrome: a nationwide population-based study in Denmark

21 January 2018

1 reference

Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.

21 January 2018

1 reference

Alzheimer's disease in Down syndrome: neurobiology and risk.

21 January 2018

1 reference

The epidemiology of Alzheimer disease in intellectual disability: results and recommendations from an international conference

21 January 2018

1 reference

Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome

21 January 2018

1 reference

Incidence and temporal patterns of adaptive behavior change in adults with mental retardation

21 January 2018

1 reference

What is the Proximal Cause of Aging?

21 January 2018

1 reference

Age at onset of dementia and age of menopause in women with Down's syndrome

21 January 2018

1 reference

An Updated Survey on Skin Conditions in Down Syndrome

21 January 2018

1 reference

Comparative survival advantage of males with down syndrome

21 January 2018

1 reference

Life expectancy in Down syndrome adults

21 January 2018

1 reference

7 January 2021

The Influence of Intellectual Disability on Life Expectancy

1 reference

7 January 2021

Variants in CYP17 and CYP19 cytochrome P450 genes are associated with onset of Alzheimer's disease in women with down syndrome

1 reference

7 January 2021

Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin

1 reference

7 January 2021

Oxidative Stress, Mitochondrial Dysfunction, and Aging

1 reference

7 January 2021

The H1 haplotype of the tau gene (MAPT) is associated with mild cognitive impairment.

1 reference

7 January 2021

Neuropsychiatric symptoms in Alzheimer's disease and vascular dementia

1 reference

7 January 2021

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report

1 reference

7 January 2021

Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study

1 reference

7 January 2021

Valvular heart disease (aortic regurgitation and mitral valve prolapse) among institutionalized adults with Down's syndrome

1 reference

7 January 2021

Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention.

1 reference

7 January 2021

The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome

1 reference

7 January 2021

Ophthalmic disorders in adults with down syndrome

1 reference

7 January 2021

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

1 reference

7 January 2021

Down syndrome and dementia: seizures and cognitive decline

1 reference

7 January 2021

Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging

1 reference

7 January 2021

Dermatological manifestations of Down's syndrome

1 reference

7 January 2021

Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk

1 reference

7 January 2021

Prevalence of diabetes in adult patients with Down's syndrome living in a residential home

1 reference

7 January 2021

Mongolian idiocy (mongolism) and maternal age

1 reference

7 January 2021

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

1 reference

7 January 2021

Misdiagnosis of thyroid disorders in down syndrome: time to re-examine the myth?

1 reference

7 January 2021

Down syndrome and thyroid disorders: a review.

1 reference

7 January 2021

Alteraciones endocrinológicas en 1.105 niños y adolescentes con síndrome de Down

1 reference

7 January 2021

Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome

1 reference

7 January 2021

ApoE2 allele, Down's syndrome, and dementia

1 reference

7 January 2021

Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia

1 reference

7 January 2021

Thyroid function and plasma immunoglobulins in subjects with Down's syndrome (DS) during ontogenesis and zinc therapy

1 reference

7 January 2021

A proteomic study of Hutchinson-Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease

1 reference

7 January 2021

Invited review: Theories of aging.

1 reference

7 January 2021

Serum estrogen levels, cognitive performance, and risk of cognitive decline in older community women

1 reference

7 January 2021

Identifiers

DOI

10.1002/DDRR.1128

1 reference

29 August 2017

1 reference