Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases (Q38122433)

29 August 2017

title

Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases (English)

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29 August 2017

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Ganji Purnachandra Nagaraju

series ordinal

1

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29 August 2017

Syed F Zafar

series ordinal

2

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29 August 2017

Bassel F El-Rayes

series ordinal

3

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29 August 2017

publication date

24 June 2013

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29 August 2017

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29 August 2017

volume

71

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29 August 2017

issue

8

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29 August 2017

page(s)

562-572

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Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women

29 August 2017

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Genistein--a dietary compound inducing hormonal and metabolic changes

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Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits

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Inhibition of IGF-1 signaling by genistein: modulation of E-cadherin expression and downregulation of β-catenin signaling in hormone refractory PC-3 prostate cancer cells.

21 January 2018

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Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein

21 January 2018

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The hypoglycemic effects of soy isoflavones on postmenopausal women.

21 January 2018

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The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status.

21 January 2018

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The soy isoflavone genistein decreases adipose deposition in mice

21 January 2018

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Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism

21 January 2018

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Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling

21 January 2018

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Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis

21 January 2018

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Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome.

21 January 2018

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Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

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Obesity and the risk for premenopausal and postmenopausal breast cancer

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Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study

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Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer.

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Associations between adipokines and obesity-related cancer.

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21 January 2018

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Genistein, a plant-derived isoflavone, counteracts the antilipolytic action of insulin in isolated rat adipocytes

21 January 2018

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Genistein inhibits differentiation of primary human adipocytes

21 January 2018

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Genistein restricts leptin secretion from rat adipocytes.

21 January 2018

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Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner

21 January 2018

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Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models

21 January 2018

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Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes

21 January 2018

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Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice

21 January 2018

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Chronic administration of genistein improves aortic reactivity of streptozotocin-diabetic rats: mode of action.

21 January 2018

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Genistein reduces hyperglycemia and islet cell loss in a high-dosage manner in rats with alloxan-induced pancreatic damage.

21 January 2018

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Tumor stroma and regulation of cancer development

21 January 2018

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Colon cancer surveillance in inflammatory bowel disease patients: current and emerging practices

21 January 2018

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Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis

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Mutagenesis associated with nitric oxide production in macrophages

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Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

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Nitric oxide is a key component in inflammation-accelerated tumorigenesis

21 January 2018

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T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

21 January 2018

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Immunomodulatory effects and improved prognosis of experimental autoimmune encephalomyelitis after O-tetradecanoyl-genistein treatment.

21 January 2018

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Genistein attenuated allergic airway inflammation by modulating the transcription factors T-bet, GATA-3 and STAT-6 in a murine model of asthma.

21 January 2018

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Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages.

21 January 2018

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Isoflavone effect on gene expression profile and biomarkers of inflammation.

21 January 2018

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Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis

21 January 2018

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Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats

21 January 2018

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Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis

21 January 2018

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Effects of the isoflavone 4',5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage

21 January 2018

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Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention

21 January 2018

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p21CIP1 is dispensable for the G2 arrest caused by genistein in human melanoma cells

21 January 2018

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Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation.

21 January 2018

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Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

21 January 2018

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Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line

21 January 2018

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Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line

21 January 2018

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Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein.

21 January 2018

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Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer

21 January 2018

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Multi-targeted therapy of cancer by genistein

21 January 2018

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Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein

21 January 2018

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Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

21 January 2018

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NF-kappaB as a potential molecular target for cancer therapy

21 January 2018

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Genistein inhibits NF-kappa B activation in prostate cancer cells

21 January 2018

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Protein Tyrosine Kinase Inhibitors Block Tumor Necrosis Factor-Induced Activation of Nuclear Factor-κB, Degradation of IκBα, Nuclear Translocation of p65, and Subsequent Gene Expression

21 January 2018

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Targeting inflammation by modulating the Jun/AP-1 pathway

21 January 2018

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Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line

21 January 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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Development of anticancer drugs targeting the MAP kinase pathway

21 January 2018

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Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes

21 January 2018

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Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor beta-mediated activation of mitogen-activated protein kinase-activated protein kinase 2-27-kDa heat shock prot

21 January 2018

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Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma

21 January 2018

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Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones

21 January 2018

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Critical role of hypoxia sensor--HIF-1α in VEGF gene activation. Implications for angiogenesis and tissue injury healing

21 January 2018

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Genetic and epigenetic regulations of prostate cancer by genistein

21 January 2018

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Epigenetic targets of bioactive dietary components for cancer prevention and therapy

21 January 2018

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Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification

21 January 2018

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Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

21 January 2018

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Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.

21 January 2018

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Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives

21 January 2018

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Cancer risk among patients with multiple sclerosis and their parents

21 January 2018

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In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer

21 January 2018

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Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/NURE.12044

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29 August 2017

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