Targeting the mTOR signaling network for Alzheimer's disease therapy (Q38121524)

29 August 2017

title

Targeting the mTOR signaling network for Alzheimer's disease therapy (English)

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29 August 2017

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2

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29 August 2017

6

Lan Tan

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29 August 2017

Chong Wang

1

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29 August 2017

Dan Miao

series ordinal

3

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29 August 2017

Zhong-Chen Wu

series ordinal

4

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29 August 2017

Meng-Shan Tan

series ordinal

5

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29 August 2017

publication date

14 July 2013

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29 August 2017

published in

Molecular Neurobiology

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29 August 2017

volume

49

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29 August 2017

issue

1

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29 August 2017

page(s)

120-135

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Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders

29 August 2017

cites work

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

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mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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Post-translational regulation of mTOR complex 1 in hypoxia and reoxygenation

21 January 2018

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GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

21 January 2018

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Amino acid signalling upstream of mTOR

21 January 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H( )-ATPase

21 January 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

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Molecular mechanisms of mTOR-mediated translational control

21 January 2018

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR complex 2 signaling and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Endoplasmic reticulum is a main localization site of mTORC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Activation of mTORC2 by Association with the Ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Significance of SGK1 in the regulation of neuronal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Gene expression analysis of mTOR pathway: association with human longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1007/S12035-013-8505-8

TOR signaling never gets old: aging, longevity and TORC1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

21 January 2018

The genetics of ageing

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Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

21 January 2018

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https://api.crossref.org/works/10.1007/S12035-013-8505-8

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR is a key modulator of ageing and age-related disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR in aging, metabolism, and cancer

21 January 2018

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https://api.crossref.org/works/10.1007/S12035-013-8505-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Mechanisms that regulate stem cell aging and life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Aβ toxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Autophagy, amyloidogenesis and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

21 January 2018

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https://api.crossref.org/works/10.1007/S12035-013-8505-8

Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-β pathology in a mouse model of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007/S12035-013-8505-8

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Autophagy impairment stimulates PS1 expression and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

The role of mTOR signaling in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Tau as a therapeutic target in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Mechanisms of tau-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

P70 S6 kinase mediates tau phosphorylation and synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR signaling: at the crossroads of plasticity, memory and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Signaling pathways underlying the rapid antidepressant actions of ketamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Mechanism for long-term memory formation when synaptic strengthening is impaired.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTORC2 controls actin polymerization required for consolidation of long-term memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Reversal of learning deficits in a Tsc2 /- mouse model of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Fighting neurodegeneration with rapamycin: mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Dissecting the role of mTOR: lessons from mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

mTOR inhibitors in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Rapamycin passes the torch: a new generation of mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Rapalogs and mTOR inhibitors as anti-aging therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12035-013-8505-8

Increased expression of Beclin-1-dependent autophagy protects against beta-amyloid-induced cell injury in PC12 cells [corrected].

21 January 2018

1 reference

12 December 2020

Neuronal cell cycle re-entry mediates Alzheimer disease-type changes

1 reference

12 December 2020

Role of the mTOR signaling pathway in epilepsy

1 reference

12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

12 December 2020

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

1 reference

12 December 2020

1 reference

12 December 2020

Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

1 reference

12 December 2020

Autophagy dysfunction in Alzheimer's disease

1 reference

12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

12 December 2020

A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model

1 reference

12 December 2020

p70 S6 kinase and tau in Alzheimer's disease.

1 reference

12 December 2020

Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy

1 reference

12 December 2020

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

1 reference

12 December 2020

Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain

1 reference

12 December 2020

10.1007/S12035-013-8505-8

Identifiers

DOI

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Dimensions Publication ID

29 August 2017

1039285820

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1 reference