Phenylalanine hydroxylase: function, structure, and regulation. (Q38086186)

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24 February 2020

title

Phenylalanine hydroxylase: function, structure, and regulation (English)

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1

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Aurora Martinez

series ordinal

2

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author name string

Marte I Flydal

series ordinal

1

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28 August 2017

Aurora Martinez

series ordinal

2

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28 August 2017

publication date

4 March 2013

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24 February 2020

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volume

65

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issue

4

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page(s)

341-349

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Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms

24 February 2020

cites work

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Allosteric regulation of phenylalanine hydroxylase

21 January 2018

1 reference

The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida

21 January 2018

1 reference

The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia

21 January 2018

1 reference

Phenylalanine hydroxylase from the sponge Geodia cydonium: implication for allorecognition and evolution of aromatic amino acid hydroxylases

21 January 2018

1 reference

The role of phenylalanine hydroxylase in melanotic encapsulation of filarial worms in two species of mosquitoes

21 January 2018

1 reference

Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans

21 January 2018

1 reference

Phenylalanine hydroxylase from Legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis

21 January 2018

1 reference

The PAH gene, phenylketonuria, and a paradigm shift

21 January 2018

1 reference

Phenylketonuria: a 21st century perspective

21 January 2018

1 reference

Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases

21 January 2018

1 reference

Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instability

21 January 2018

1 reference

Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

21 January 2018

1 reference

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations

21 January 2018

1 reference

Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major

21 January 2018

1 reference

The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum

21 January 2018

1 reference

Missense mutations in the N-terminal domain of human phenylalanine hydroxylase interfere with binding of regulatory phenylalanine

21 January 2018

1 reference

Tetrahydrobiopterin: biochemistry and pathophysiology

21 January 2018

1 reference

Structural basis of autoregulation of phenylalanine hydroxylase

21 January 2018

1 reference

Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria

21 January 2018

1 reference

Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism.

21 January 2018

1 reference

Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase

21 January 2018

1 reference

Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase

21 January 2018

1 reference

Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis

21 January 2018

1 reference

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects

21 January 2018

1 reference

Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation

21 January 2018

1 reference

Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

21 January 2018

1 reference

Evidence for a high-spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylase

21 January 2018

1 reference

Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.

21 January 2018

1 reference

Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase

21 January 2018

1 reference

L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

21 January 2018

1 reference

Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications

21 January 2018

1 reference

Coordinate regulation of tetrahydrobiopterin turnover and phenylalanine hydroxylase activity in rat liver cells

21 January 2018

1 reference

Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts.

21 January 2018

1 reference

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa

21 January 2018

1 reference

Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster

21 January 2018

1 reference

Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates

21 January 2018

1 reference

Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability

21 January 2018

1 reference

Intrinsic and environmental mutagenesis drive diversification and persistence of Pseudomonas aeruginosa in chronic lung infections

21 January 2018

1 reference

Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate.

21 January 2018

1 reference

The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activity

21 January 2018

1 reference

Order of substrate binding in bacterial phenylalanine hydroxylase and its mechanistic implication for pterin-dependent oxygenases

21 January 2018

1 reference

Involvement of the global Crp regulator in cyclic AMP-dependent utilization of aromatic amino acids by Pseudomonas putida.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IUB.1150

1 reference

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24 February 2020

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