Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration. (Q38081918)

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24 February 2020

title

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration (English)

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Markus Glatzel

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Johannes Prox

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Berta Puig

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Frank Dohler

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Clemens Falker

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Susanne Krasemann

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English

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publication date

13 March 2013

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volume

280

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issue

18

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page(s)

4338-4347

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N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells.

24 February 2020

cites work

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The prion's elusive reason for being

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Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

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Molecular basis of cerebral neurodegeneration in prion diseases.

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Mice devoid of PrP are resistant to scrapie

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Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

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Normal host prion protein necessary for scrapie-induced neurotoxicity

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Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice

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Anchorless prion protein results in infectious amyloid disease without clinical scrapie

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Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

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Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

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Prion protein and Abeta-related synaptic toxicity impairment

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The prion protein as a receptor for amyloid-beta.

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Memory impairment in transgenic Alzheimer mice requires cellular prion protein

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Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

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Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

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Aβ Inhibition of Ionic Conductance in Mouse Basal Forebrain Neurons Is Dependent upon the Cellular Prion Protein PrPC

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Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

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PrP(C) homodimerization stimulates the production of PrPC cleaved fragments PrPN1 and PrPC1.

21 January 2018

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Amyloid-beta oligomers increase the localization of prion protein at the cell surface

21 January 2018

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Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

21 January 2018

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The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

21 January 2018

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

21 January 2018

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Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

21 January 2018

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Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

21 January 2018

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The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

21 January 2018

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Signal transduction through prion protein

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PrP Antibodies Do Not Trigger Mouse Hippocampal Neuron Apoptosis

21 January 2018

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Cleavage of the amino terminus of the prion protein by reactive oxygen species.

21 January 2018

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Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.

21 January 2018

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Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

21 January 2018

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Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent

21 January 2018

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The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.

21 January 2018

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The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

21 January 2018

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Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

21 January 2018

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Truncated forms of the human prion protein in normal brain and in prion diseases

21 January 2018

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Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons

21 January 2018

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Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

21 January 2018

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α-Cleavage of cellular prion protein

21 January 2018

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Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

21 January 2018

1 reference

Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo

21 January 2018

1 reference

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

21 January 2018

1 reference

Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle

21 January 2018

1 reference

Separate mechanisms act concurrently to shed and release the prion protein from the cell

21 January 2018

1 reference

Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations

21 January 2018

1 reference

Toward molecular dissection of PrPC-PrPSc interactions

21 January 2018

1 reference

The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

21 January 2018

1 reference

Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection

21 January 2018

1 reference

A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.

21 January 2018

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Axonal prion protein is required for peripheral myelin maintenance

21 January 2018

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Lethal recessive myelin toxicity of prion protein lacking its central domain

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Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

21 January 2018

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α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death

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Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.

21 January 2018

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Targeting the cellular prion protein to treat neurodegeneration.

21 January 2018

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Stress-protective signalling of prion protein is corrupted by scrapie prions

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Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor

21 January 2018

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A soluble form of prion protein in human cerebrospinal fluid: implications for prion-related encephalopathies

21 January 2018

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The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity

21 January 2018

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ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

21 January 2018

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ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

21 January 2018

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The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

21 January 2018

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Regulation of amyloid-β production by the prion protein

21 January 2018

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The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding

21 January 2018

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Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells

21 January 2018

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Cell-free formation of protease-resistant prion protein.

21 January 2018

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Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring

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Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.

21 January 2018

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

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Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

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Ectodomain shedding and ADAMs in development

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Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.

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TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

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