Compartmentation of cAMP signalling in cardiomyocytes in health and disease (Q38079253)

28 August 2017

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title

Compartmentation of cAMP signalling in cardiomyocytes in health and disease (English)

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Collaborative Research Centre (CRC) 1002: "Modulatory Units in Heart Failure"

28 August 2017

sponsor

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author name string

R K Perera

series ordinal

1

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28 August 2017

V O Nikolaev

series ordinal

2

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28 August 2017

publication date

26 February 2013

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28 August 2017

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28 August 2017

volume

207

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28 August 2017

issue

4

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28 August 2017

page(s)

650-662

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Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals

28 August 2017

cites work

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Fluorescence ratio imaging of cyclic AMP in single cells

21 January 2018

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CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

21 January 2018

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Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2 Release and Cardiac Contractility, Independently of L-Type Ca 2 Current

21 January 2018

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Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes

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The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants

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Cyclic AMP underpins suppression by regulatory T cells

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Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation

21 January 2018

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Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states

21 January 2018

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Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

21 January 2018

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AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway

21 January 2018

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Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes

21 January 2018

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RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling

21 January 2018

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Mutation of an A-kinase-anchoring protein causes long-QT syndrome

21 January 2018

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Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

21 January 2018

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Protein kinase A type I and type II define distinct intracellular signaling compartments

21 January 2018

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Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

21 January 2018

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A-kinase anchoring proteins: scaffolding proteins in the heart.

21 January 2018

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

21 January 2018

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Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins

21 January 2018

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Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice

21 January 2018

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Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

21 January 2018

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cAMP: novel concepts in compartmentalised signalling.

21 January 2018

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

21 January 2018

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Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.

21 January 2018

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Epac: defining a new mechanism for cAMP action

21 January 2018

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The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion

21 January 2018

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Differences in the Structural Characteristics of Adult Guinea Pig and Rat Cardiomyocytes during Their Adaptation and Maintenance in Long-Term Cultures: Confocal Microscopy Study

21 January 2018

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

21 January 2018

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cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

21 January 2018

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Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15

21 January 2018

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Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

21 January 2018

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cAMP compartmentation is responsible for a local activation of cardiac Ca2 channels by beta-adrenergic agonists

21 January 2018

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Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression

21 January 2018

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The molecular biology of memory storage: a dialogue between genes and synapses

21 January 2018

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In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves

21 January 2018

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A family of cAMP-binding proteins that directly activate Rap1

21 January 2018

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PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes

21 January 2018

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Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus

21 January 2018

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Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.

21 January 2018

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Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

21 January 2018

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Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

21 January 2018

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The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart

21 January 2018

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Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes

21 January 2018

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What is the role of beta-adrenergic signaling in heart failure?

21 January 2018

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Ca2 cycling and new therapeutic approaches for heart failure

21 January 2018

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AKAP complex regulates Ca2 re-uptake into heart sarcoplasmic reticulum

21 January 2018

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beta-Arrestin-dependent activation of Ca(2 )/calmodulin kinase II after beta(1)-adrenergic receptor stimulation

21 January 2018

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The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

21 January 2018

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

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Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

21 January 2018

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Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization

21 January 2018

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AKAP-scaffolding proteins and regulation of cardiac physiology.

21 January 2018

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Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

21 January 2018

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Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure

21 January 2018

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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

21 January 2018

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Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications

21 January 2018

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Role of Ca2 /calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

21 January 2018

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Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

21 January 2018

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Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle.

21 January 2018

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Role of nuclear Ca2 /calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival

21 January 2018

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CaMKII-dependent diastolic SR Ca2 leak and elevated diastolic Ca2 levels in right atrial myocardium of patients with atrial fibrillation

21 January 2018

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Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels

21 January 2018

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Monitoring of cAMP synthesis and degradation in living cells

21 January 2018

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Novel single chain cAMP sensors for receptor-induced signal propagation.

21 January 2018

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Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β 1 -Adrenergic but Locally Confined β 2 -Adrenergic Receptor–Mediated Signaling

21 January 2018

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Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.

21 January 2018

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Nanoscale live-cell imaging using hopping probe ion conductance microscopy

21 January 2018

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Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.

21 January 2018

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The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling

21 January 2018

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

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Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes

21 January 2018

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Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart

21 January 2018

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Anchoring proteins as regulators of signaling pathways.

21 January 2018

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Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

21 January 2018

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A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

21 January 2018

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Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

21 January 2018

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Conserved expression and functions of PDE4 in rodent and human heart

21 January 2018

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Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

21 January 2018

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Epac in cardiac calcium signaling.

21 January 2018

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Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation

21 January 2018

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A-kinase anchoring proteins: getting to the heart of the matter.

21 January 2018

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Creating order from chaos: cellular regulation by kinase anchoring

21 January 2018

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Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

21 January 2018

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Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

21 January 2018

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Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

21 January 2018

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Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

21 January 2018

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Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2 Handling

21 January 2018

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cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

21 January 2018

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Oscillatory control of insulin secretion

21 January 2018

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A-kinase anchoring proteins as potential drug targets

21 January 2018

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Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes

21 January 2018

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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

21 January 2018

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Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

21 January 2018

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Subclasses of cyclic AMP phosphodiesterase in cardiac muscle

21 January 2018

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cAMP detection methods in HTS: selecting the best from the rest

21 January 2018

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Live-cell imaging of cAMP dynamics

21 January 2018

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Compartmentalization of β-Adrenergic Signals in Cardiomyocytes

21 January 2018

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Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins

21 January 2018

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cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies

21 January 2018

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Spatial control of cAMP signalling in health and disease

21 January 2018

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cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology

21 January 2018

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Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

21 January 2018

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Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling

21 January 2018

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Altered Expression of PDE1 and PDE4 Cyclic Nucleotide Phosphodiesterase Isoforms in 7-oxo-prostacyclin-preconditioned Rat Heart

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/APHA.12077

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28 August 2017

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