Bacterial toxin inhibitors based on multivalent scaffolds (Q38069445)

28 August 2017

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title

Bacterial toxin inhibitors based on multivalent scaffolds (English)

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28 August 2017

2

W Bruce Turnbull

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28 August 2017

Thomas R Branson

1

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28 August 2017

publication date

21 December 2012

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full work available at URL

28 August 2017

http://eprints.whiterose.ac.uk/79772/

content deliverer

White Rose Research Online

object of statement has role

published version

copyright license

Creative Commons Attribution

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https://doi.org/10.1039/c2cs35430f

copyright license

Creative Commons Attribution

object of statement has role

published version

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published in

Chemical Society Reviews

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28 August 2017

volume

42

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28 August 2017

issue

11

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28 August 2017

page(s)

4613-4622

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Vibrio cholerae: cholera toxin

28 August 2017

cites work

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Shiga toxin-producing Escherichia coli O104:H4: a new challenge for microbiology

21 January 2018

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Targeting Bacterial Toxins

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Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review)

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Endocytosis and retrograde transport of Shiga toxin.

21 January 2018

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Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.

21 January 2018

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The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site

21 January 2018

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Structure of the Shiga-like Toxin I B-Pentamer Complexed with an Analogue of Its Receptor Gb3,

21 January 2018

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Blood group antigen recognition by Escherichia coli heat-labile enterotoxin

21 January 2018

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Both El Tor and classical cholera toxin bind blood group determinants.

21 January 2018

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Towards a structural basis for the relationship between blood group and the severity of El Tor cholera

21 January 2018

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Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetry

21 January 2018

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Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor

21 January 2018

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Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules

21 January 2018

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Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.

21 January 2018

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Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes

21 January 2018

1 reference

Synthesis of an artificial glycoconjugate polymer carrying Pk-antigenic trisaccharide and its potent neutralization activity against Shiga-like toxin

21 January 2018

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Multivalent inhibition of AB(5) toxins

21 January 2018

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Oral therapeutic agents with highly clustered globotriose for treatment of Shiga toxigenic Escherichia coli infections.

21 January 2018

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Effects of polymer structure on the inhibition of cholera toxin by linear polypeptide-based glycopolymers

21 January 2018

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Architecture Effects on the Binding of Cholera Toxin by Helical Glycopolypeptides

21 January 2018

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Effects of Saccharide Spacing and Chain Extension on Toxin Inhibition by Glycopolypeptides of Well-Defined Architecture

21 January 2018

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Manipulation of electrostatic and saccharide linker interactions in the design of efficient glycopolypeptide-based cholera toxin inhibitors

21 January 2018

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Design and synthesis of glycodendrimers

21 January 2018

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Design and creativity in synthesis of multivalent neoglycoconjugates

21 January 2018

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Oligosaccharide-derivatized dendrimers: defined multivalent inhibitors of the adherence of the cholera toxin B subunit and the heat labile enterotoxin of E. coli to GM1

21 January 2018

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Inhibition of the adherence of cholera toxin and the heat-labile enterotoxin of Escherichia coli to cell-surface GM1 by oligosaccharide-derivatized dendrimers

21 January 2018

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Maximising multivalency effects in protein-carbohydrate interactions

21 January 2018

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Synthesis and cholera toxin binding properties of multivalent GM1 mimics

21 January 2018

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Strong inhibition of cholera toxin binding by galactose dendrimers.

21 January 2018

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The influence of ligand valency on aggregation mechanisms for inhibiting bacterial toxins.

21 January 2018

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A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli O157:H7.

21 January 2018

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Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands

21 January 2018

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Controlling Signal Transduction with Synthetic Ligands

21 January 2018

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Large-scale millisecond intersubunit dynamics in the B subunit homopentamer of the toxin derived from Escherichia coli O157.

21 January 2018

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Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands

21 January 2018

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Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin

21 January 2018

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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

21 January 2018

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Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets

21 January 2018

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Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands

21 January 2018

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An entropically efficient supramolecular inhibition strategy for Shiga toxins

21 January 2018

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In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins

21 January 2018

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Strong Inhibition of Cholera Toxin by Multivalent GM1 Derivatives

21 January 2018

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Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C2CS35430F

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Dimensions Publication ID

28 August 2017

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1041295511

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