Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate. (Q38068540)

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20 February 2020

review article

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title

Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate (English)

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20 February 2020

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20 February 2020

Henk-Jan Guchelaar

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4

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20 February 2020

author name string

Cristina Lucía Dávila-Fajardo

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1

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20 February 2020

José Cabeza Barrera

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3

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20 February 2020

publication date

1 January 2013

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20 February 2020

number of pages

11

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published in

Pharmacogenomics

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volume

14

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20 February 2020

issue

1

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20 February 2020

page(s)

63-73

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Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.

20 February 2020

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Methotrexate--how does it really work?

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Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.

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Hepatotoxicity rates do not differ in patients with rheumatoid arthritis and psoriasis treated with methotrexate

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Determinants of serious liver disease among patients receiving low-dose methotrexate for rheumatoid arthritis

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Outcome and prognostic markers in severe drug-induced liver disease

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Liver histology in patients receiving low dose pulse methotrexate for the treatment of rheumatoid arthritis

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Drug-Related Hepatotoxicity

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Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes

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Liver histology in rheumatoid arthritis patients receiving long-term methotrexate therapy. A prospective study with baseline and sequential biopsy samples

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Histopathologic findings in the liver of rheumatoid arthritis patients treated with long-term bolus methotrexate

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The life-threatening complications of dermatologic therapies

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Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses

21 January 2018

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Pharmacogenetics and folate metabolism -- a promising direction

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Methotrexate pharmacogenetics: the first step toward individualized therapy in rheumatoid arthritis

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A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity

21 January 2018

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677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis

21 January 2018

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Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis

21 January 2018

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Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases.

21 January 2018

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Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity

21 January 2018

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Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis

21 January 2018

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Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis

21 January 2018

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Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX.

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Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis

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Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis

21 January 2018

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Translating pharmacogenomics: challenges on the road to the clinic

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Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries

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Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions

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21 January 2018

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Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in t

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