Immunotherapy in prion disease (Q38068103)

28 August 2017

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title

Immunotherapy in prion disease (English)

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28 August 2017

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5

Richard Dodel

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28 August 2017

3

Michael Bacher

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28 August 2017

Yvonne Roettger

1

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28 August 2017

Yansheng Du

series ordinal

2

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28 August 2017

Inga Zerr

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4

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28 August 2017

Jan-Philipp Bach

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6

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28 August 2017

language of work or name

English

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publication date

18 December 2012

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28 August 2017

published in

Nature Reviews Neurology

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28 August 2017

volume

9

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28 August 2017

issue

2

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28 August 2017

page(s)

98-105

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A protease-resistant protein is a structural component of the scrapie prion

28 August 2017

cites work

1 reference

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Active and passive immunotherapy for neurodegenerative disorders

31 March 2020

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A cellular gene encodes scrapie PrP 27-30 protein

31 March 2020

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

31 March 2020

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Altered circadian activity rhythms and sleep in mice devoid of prion protein

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Mossy fibre reorganization in the hippocampus of prion protein null mice

31 March 2020

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A neurotoxic prion protein fragment induces rat astroglial proliferation and hypertrophy.

31 March 2020

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Regulation of intracellular free calcium levels by the cellular prion protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Prion Protein-Deficient Cells Show Altered Response to Oxidative Stress Due to Decreased SOD-1 Activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Astrocytic glutamate uptake and prion protein expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Signal transduction through prion protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Upregulation of cellular prion protein (PrPc) after focal cerebral ischemia and influence of lesion severity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Deletion of cellular prion protein results in reduced Akt activation, enhanced postischemic caspase-3 activation, and exacerbation of ischemic brain injury

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Prions prevent brain damage after experimental brain injury: a preliminary report

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

PrPC directly interacts with proteins involved in signaling pathways

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Cellular prion protein transduces neuroprotective signals

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Alzheimer's disease: A prion protein connection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Prion protein and Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Octarepeat changes of prion protein in Parkinson's disease

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Transepithelial prion transport by M cells

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Antiprion immunotherapy: to suppress or to stimulate?

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Prion diseases and the spleen

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

The role of the spleen in the neuroinvasion of scrapie in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

A crucial role for B cells in neuroinvasive scrapie.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

PrP expression in B lymphocytes is not required for prion neuroinvasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Immune system and peripheral nerves in propagation of prions to CNS.

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

A route for prion neuroinvasion.

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Five questions on prion diseases

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Generation of cell lines propagating infectious prions and the isolation and characterization of cell-derived exosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Retrovirus infection strongly enhances scrapie infectivity release in cell culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Immunological studies of scrapie infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Generation of monoclonal antibodies against human prion proteins in PrP0/0 mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

New insight into abnormal prion protein using monoclonal antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Cell mediated immune responses against human prion protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Identification of two immunogenic domains of the prion protein--PrP--which activate class II-restricted T cells and elicit antibody responses against the native molecule.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Protein conformation significantly influences immune responses to prion protein.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Generation of antibodies against prion protein by scrapie-infected cell immunization of PrP(0/0) mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

A systematic review of prion therapeutics in experimental models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Vaccine approaches to prevent and treat prion infection : progress and challenges

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Generation of antibodies against prion protein in wild-type mice via helix 1 peptide immunization

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Multiple antigenic peptides facilitate generation of anti-prion antibodies

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Modulation of proteinase-K resistant prion protein by prion peptide immunization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Mouse vaccination with dendritic cells loaded with prion protein peptides overcomes tolerance and delays scrapie

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Induction of antibodies against murine full-length prion protein in wild-type mice

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Immunization delays the onset of prion disease in mice.

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Immunization with recombinant bovine but not mouse prion protein delays the onset of disease in mice inoculated with a mouse-adapted prion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Unswitched immunoglobulin M response prolongs mouse survival in prion disease.

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

PrP Antibodies Do Not Trigger Mouse Hippocampal Neuron Apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Anti-prion antibodies for prophylaxis following prion exposure in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Human anti-prion antibodies block prion peptide fibril formation and neurotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Spreading of prions from the immune to the peripheral nervous system: a potential implication of dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Naturally Occurring Autoantibodies against β-Amyloid: Investigating Their Role in Transgenic Animal andIn VitroModels of Alzheimer's Disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2012.258

Cellular biology of prion diseases

31 March 2020

1 reference

12 December 2020

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12 December 2020

Failure to demonstrate a humoral immune response to scrapie infection in mice

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12 December 2020

Scrapie prion proteins are synthesized in neurons

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12 December 2020

The immune system and prion diseases: a relationship of complicity and blindness.

1 reference

12 December 2020

10.1038/NRNEUROL.2012.258

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1045431269

0 references

1 reference