Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and nuclear factor-κB (NF-κB) nuclear translocation (Q38066579)

28 August 2017

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title

Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and nuclear factor-κB (NF-κB) nuclear translocation (English)

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28 August 2017

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Fabian Zanella

1

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28 August 2017

Nuno R Dos Santos

series ordinal

2

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28 August 2017

Wolfgang Link

series ordinal

3

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28 August 2017

publication date

2 January 2013

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28 August 2017

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28 August 2017

volume

14

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28 August 2017

issue

3

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28 August 2017

page(s)

247-258

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Protein localization in disease and therapy.

28 August 2017

cites work

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First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes

21 January 2018

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The nuclear pore complex: bridging nuclear transport and gene regulation

21 January 2018

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The nuclear pore complex and nuclear transport

21 January 2018

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The structure of the nuclear pore complex

21 January 2018

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Transport between the cell nucleus and the cytoplasm

21 January 2018

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Nucleocytoplasmic transport: the soluble phase

21 January 2018

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Importin-beta-like nuclear transport receptors

21 January 2018

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Nuclear export of proteins and drug resistance in cancer

21 January 2018

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Regulation of nuclear transport: central role in development and transformation?

21 January 2018

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Nuclear transport and cancer: from mechanism to intervention

21 January 2018

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Therapeutic targeting of nuclear protein import in pathological cell conditions

21 January 2018

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Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport

21 January 2018

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Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53.

21 January 2018

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Nuclear pore proteins and cancer

21 January 2018

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Molecular cloning of a new transforming gene from a chemically transformed human cell line.

21 January 2018

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The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

21 January 2018

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

21 January 2018

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Nuclear localization signals and human disease

21 January 2018

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Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

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CRM1-mediated nuclear export of proteins and drug resistance in cancer

21 January 2018

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Unravelling the tumor-suppressive functions of FOXO proteins

21 January 2018

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Nuclear transport: target for therapy

21 January 2018

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High content screening: seeing is believing.

21 January 2018

1 reference

Live-cell fluorescent biosensors for activated signaling proteins

21 January 2018

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Building and breeding molecules to spy on cells and tumors

21 January 2018

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Protein translocation assays: key tools for accessing new biological information with high-throughput microscopy

21 January 2018

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Targeting and tracing antigens in live cells with fluorescent nanobodies

21 January 2018

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Novel antibody derivatives for proteome and high-content analysis

21 January 2018

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High throughput microscopy: from raw images to discoveries

21 January 2018

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An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays

21 January 2018

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A personal perspective on high-content screening (HCS): from the beginning

21 January 2018

1 reference

Inflammatory pathway analysis using a high content screening platform

21 January 2018

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A Disease-Relevant High-Content Screening Assay to Identify Anti-Inflammatory Compounds for Use in Cystic Fibrosis

21 January 2018

1 reference

Microscale functional cytomics for studying hematologic cancers

21 January 2018

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

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Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

21 January 2018

1 reference

Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening

21 January 2018

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Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells.

21 January 2018

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Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators

21 January 2018

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RNAi screening for kinases and phosphatases identifies FoxO regulators

21 January 2018

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High content screening of CXCR2-dependent signalling pathways.

21 January 2018

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A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

21 January 2018

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Development of an image analysis screen for estrogen receptor alpha (ERα) ligands through measurement of nuclear translocation dynamics

21 January 2018

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Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform

21 January 2018

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High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer

21 January 2018

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Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen

21 January 2018

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Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer

21 January 2018

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Automated high content screening for phosphoinositide 3 kinase inhibition using an AKT 1 redistribution assay.

21 January 2018

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Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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21 January 2018

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FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

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The emerging roles of forkhead box (Fox) proteins in cancer

21 January 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

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The FoxO family in cardiac function and dysfunction

21 January 2018

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The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling

21 January 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

21 January 2018

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

21 January 2018

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Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system.

21 January 2018

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Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL.

21 January 2018

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Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

21 January 2018

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Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

21 January 2018

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Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

21 January 2018

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Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia

21 January 2018

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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

21 January 2018

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Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

21 January 2018

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The psammaplysenes, specific inhibitors of FOXO1a nuclear export

21 January 2018

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Insulin Inhibition of Transcription Stimulated by the Forkhead Protein Foxo1 Is Not Solely due to Nuclear Exclusion

21 January 2018

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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

21 January 2018

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The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors

21 January 2018

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A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose

21 January 2018

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O-GlcNAc regulates FoxO activation in response to glucose

21 January 2018

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Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.

21 January 2018

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Missing pieces in the NF-kappaB puzzle

21 January 2018

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Shared principles in NF-kappaB signaling

21 January 2018

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Regulation and function of NF-kappaB transcription factors in the immune system

21 January 2018

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21 January 2018

Signaling to NF-kappaB

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response

21 January 2018

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PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit

21 January 2018

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Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

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Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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Non-canonical NF-κB signaling pathway

21 January 2018

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A fourth IkappaB protein within the NF-kappaB signaling module

21 January 2018

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

21 January 2018

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

21 January 2018

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Regulation of NF-kappaB2/p100 processing by its nuclear shuttling.

21 January 2018

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Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation

21 January 2018

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High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines

21 January 2018

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The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

21 January 2018

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Oscillations in NF-kappaB signaling control the dynamics of gene expression

21 January 2018

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Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.

21 January 2018

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A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity

21 January 2018

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Achieving stability of lipopolysaccharide-induced NF-kappaB activation

21 January 2018

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High-throughput, single-cell NF-κB dynamics

21 January 2018

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Autoregulatory feedback loops terminating the NF-kappaB response

21 January 2018

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Measurement of single-cell dynamics.

21 January 2018

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Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

21 January 2018

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Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.

21 January 2018

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Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

21 January 2018

1 reference

Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models

21 January 2018

1 reference

SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation

21 January 2018

1 reference

Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation

21 January 2018

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RelB-dependent stromal cells promote T-cell leukemogenesis

21 January 2018

1 reference

High-content classification of nucleocytoplasmic import or export inhibitors

21 January 2018

1 reference

Screening for activators of the wingless type/Frizzled pathway by automated fluorescent microscopy

21 January 2018

1 reference

Kinase inhibitors modulate huntingtin cell localization and toxicity.

21 January 2018

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Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors

21 January 2018

1 reference

Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes

21 January 2018

1 reference

Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.

21 January 2018

1 reference

Inhibitory kappa B kinases as targets for pharmacological regulation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/TRA.12034

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28 August 2017

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