The genetics of type 2 diabetes and its clinical relevance (Q38061186)

28 August 2017

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title

The genetics of type 2 diabetes and its clinical relevance (English)

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28 August 2017

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A Pal

1

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28 August 2017

M I McCarthy

series ordinal

2

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28 August 2017

publication date

4 December 2012

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28 August 2017

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28 August 2017

volume

83

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28 August 2017

issue

4

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28 August 2017

page(s)

297-306

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

28 August 2017

cites work

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Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

21 January 2018

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The future of genetic studies of complex human diseases

21 January 2018

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

21 January 2018

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

21 January 2018

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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

21 January 2018

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A genome-wide association search for type 2 diabetes genes in African Americans

21 January 2018

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 January 2018

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

21 January 2018

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Genome-wide association studies provide new insights into type 2 diabetes aetiology

21 January 2018

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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

21 January 2018

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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

21 January 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

21 January 2018

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

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Variants in MTNR1B influence fasting glucose levels

21 January 2018

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Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention

21 January 2018

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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

21 January 2018

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The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease

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Type 2 diabetes risk alleles are associated with reduced size at birth

21 January 2018

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Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

21 January 2018

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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

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A map of open chromatin in human pancreatic islets

21 January 2018

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TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

21 January 2018

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Wnt signaling regulates pancreatic beta cell proliferation

21 January 2018

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Cancer as an endocrine problem

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Multiple loci identified in a genome-wide association study of prostate cancer

21 January 2018

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The regulation of INK4/ARF in cancer and aging

21 January 2018

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p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

21 January 2018

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Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations

21 January 2018

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Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.

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Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

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PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

21 January 2018

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Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young

21 January 2018

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Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein

21 January 2018

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Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations

21 January 2018

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Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

21 January 2018

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21 January 2018

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

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The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity

21 January 2018

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Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

21 January 2018

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Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

21 January 2018

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Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

21 January 2018

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Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

21 January 2018

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XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients

21 January 2018

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

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The clinical application of genetic testing in type 2 diabetes: a patient and physician survey

21 January 2018

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Genotype score in addition to common risk factors for prediction of type 2 diabetes

21 January 2018

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

21 January 2018

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Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

21 January 2018

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Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

21 January 2018

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Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

21 January 2018

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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

21 January 2018

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Principles in genetic risk assessment

21 January 2018

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Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy

21 January 2018

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Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection

21 January 2018

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Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes

21 January 2018

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An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes

21 January 2018

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Genetic associations in diabetic nephropathy: a meta-analysis

21 January 2018

1 reference

Tamm-Horsfall glycoprotein: biology and clinical relevance

21 January 2018

1 reference

Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases

21 January 2018

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Multiple loci associated with indices of renal function and chronic kidney disease

21 January 2018

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Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

21 January 2018

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Genetic cause of hyperglycaemia and response to treatment in diabetes

21 January 2018

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Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

21 January 2018

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

21 January 2018

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Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program

21 January 2018

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

21 January 2018

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

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Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

21 January 2018

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Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients

21 January 2018

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The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes

21 January 2018

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Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K( ) channel

21 January 2018

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Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes

21 January 2018

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Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma2 gene on rosiglitazone response in type 2 diabetes

21 January 2018

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Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of

21 January 2018

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Sequence variation in PPARG may underlie differential response to troglitazone

21 January 2018

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Clan genomics and the complex architecture of human disease

21 January 2018

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Recent explosive human population growth has resulted in an excess of rare genetic variants

21 January 2018

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The mystery of missing heritability: Genetic interactions create phantom heritability

21 January 2018

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Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

21 January 2018

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Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

21 January 2018

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Uromodulin gene variant is associated with type 2 diabetic nephropathy

21 January 2018

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Immature Renal Structures Associated With a Novel UMOD Sequence Variant

21 January 2018

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Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/CGE.12055

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28 August 2017

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