Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection (Q38044678)

27 August 2017

title

Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection (English)

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27 August 2017

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Kai A Kropp

6

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Matthias J Reddehase

object named as

Matthias J Reddehase

10

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author name string

Christof K Seckert

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27 August 2017

Marion Griessl

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27 August 2017

Julia K Büttner

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27 August 2017

Sabine Scheller

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27 August 2017

Christian O Simon

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27 August 2017

Angélique Renzaho

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27 August 2017

Birgit Kühnapfel

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27 August 2017

Natascha K A Grzimek

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27 August 2017

publication date

19 September 2012

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Medical Microbiology and Immunology

27 August 2017

published in

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27 August 2017

volume

201

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27 August 2017

issue

4

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27 August 2017

page(s)

551-566

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Mouse models of cytomegalovirus latency: overview

27 August 2017

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A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

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A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus

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Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication

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Expression of an altered ribonucleotide reductase activity associated with the replication of murine cytomegalovirus in quiescent fibroblasts.

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Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissues

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Synergism between the components of the bipartite major immediate-early transcriptional enhancer of murine cytomegalovirus does not accelerate virus replication in cell culture and host tissues

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Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

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Immune evasion proteins enhance cytomegalovirus latency in the lungs.

21 January 2018

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Allogeneic transplantation induces expression of cytomegalovirus immediate-early genes in vivo: a model for reactivation from latency

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Preemptive CD8 T-Cell Immunotherapy of Acute Cytomegalovirus Infection Prevents Lethal Disease, Limits the Burden of Latent Viral Genomes, and Reduces the Risk of Virus Recurrence

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Patchwork pattern of transcriptional reactivation in the lungs indicates sequential checkpoints in the transition from murine cytomegalovirus latency to recurrence

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Intra-abdominal bacterial infection reactivates latent pulmonary cytomegalovirus in immunocompetent mice

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Lungs are a major organ site of cytomegalovirus latency and recurrence.

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Initiation of cytomegalovirus infection at ND10.

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12 December 2020

10.1007/S00430-012-0273-Y

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

1048537422

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