Proteinases as virulence factors in Leishmania spp. infection in mammals. (Q38032623)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json

10 February 2020

title

Proteinases as virulence factors in Leishmania spp. infection in mammals (English)

1 reference

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10 February 2020

Leishmania

1 reference

2

1 reference

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10 February 2020

author name string

Mariana Silva-Almeida

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json

10 February 2020

Michelle Lopes Ribeiro-Guimarães

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json

10 February 2020

Carlos Roberto Alves

series ordinal

4

1 reference

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10 February 2020

publication date

7 August 2012

1 reference

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10 February 2020

published in

Parasites and Vectors

1 reference

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10 February 2020

volume

5

1 reference

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10 February 2020

page(s)

160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json

In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection.

10 February 2020

cites work

1 reference

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6 September 2017

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Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions

6 September 2017

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Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response

6 September 2017

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Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

6 September 2017

1 reference

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Diffuse cutaneous leishmaniasis associated with the immune reconstitution inflammatory syndrome

6 September 2017

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Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis.

6 September 2017

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Mucosal leishmaniasis: epidemiological and clinical aspects

6 September 2017

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Proteases in parasitic diseases

6 September 2017

1 reference

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Polymorphisms of cpb multicopy genes in the Leishmania (Leishmania) donovani complex

6 September 2017

1 reference

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Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.

6 September 2017

1 reference

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The current status of zoonotic leishmaniases and approaches to disease control

6 September 2017

1 reference

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Role of Leishmania (Leishmania) chagasi amastigote cysteine protease in intracellular parasite survival: studies by gene disruption and antisense mRNA inhibition

6 September 2017

1 reference

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Cysteine peptidases as virulence factors of Leishmania

6 September 2017

1 reference

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New insights into the developmental biology and transmission mechanisms of Leishmania.

6 September 2017

1 reference

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Leishmaniasis: current situation and new perspectives

6 September 2017

1 reference

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The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function.

6 September 2017

1 reference

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The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts

6 September 2017

1 reference

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Cloning and characterisation of a cysteine proteinase gene expressed in amastigotes of Leishmania (L.) amazonensis

6 September 2017

1 reference

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Interleukin 10 blocks matrix metalloproteinase-2 and membrane type 1-matrix metalloproteinase synthesis in primary human prostate tumor lines

6 September 2017

1 reference

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Cysteine proteases of parasitic organisms

6 September 2017

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Leishmania infection and virulence

6 September 2017

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Proteophosphoglycans of Leishmania

6 September 2017

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Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.

6 September 2017

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Molecular cloning and characterization of a novel repeat-containing Leishmania major gene, ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor

6 September 2017

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target

6 September 2017

1 reference

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Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

6 September 2017

1 reference

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The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63)

6 September 2017

1 reference

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Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids

6 September 2017

1 reference

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Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array

6 September 2017

1 reference

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Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein

6 September 2017

1 reference

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The Leishmania receptor for macrophages is a lipid-containing glycoconjugate

6 September 2017

1 reference

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Immunopathology of American cutaneous leishmaniasis

6 September 2017

1 reference

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Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions.

6 September 2017

1 reference

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Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63.

14 September 2017

1 reference

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Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.

14 September 2017

1 reference

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A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression.

14 September 2017

1 reference

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Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models

14 September 2017

1 reference

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Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo

14 September 2017

1 reference

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Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages.

14 September 2017

1 reference

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Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages

14 September 2017

1 reference

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Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses

28 September 2017

1 reference

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Identification and purification of membrane and soluble forms of the major surface protein of Leishmania promastigotes.

23 June 2018

1 reference

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Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana

23 June 2018

1 reference

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Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis.

23 June 2018

1 reference

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Leishmaniasis, an emerging imported infection: report of 20 cases from Australia

31 August 2018

1 reference

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The C-terminal extension of Leishmania pifanoi amastigote-specific cysteine proteinase Lpcys2: a putative function in macrophage infection.

31 August 2018

1 reference

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Leishmania mexicana: participation of NF-kappaB in the differential production of IL-12 in dendritic cells and monocytes induced by lipophosphoglycan (LPG).

31 August 2018

1 reference

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In vitro evidence for metallopeptidase participation in hepatocyte damage induced by Leishmania chagasi-infected macrophages.

31 August 2018

1 reference

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Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.

31 August 2018

1 reference

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Leishmania amazonensis: early proteinase activities during promastigote-amastigote differentiation in vitro

31 August 2018

1 reference

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Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Th1 and Th2 immunological profile induced by cysteine proteinase in murine leishmaniasis

31 August 2018

1 reference

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Subcellular localization of an extracellular serine protease in Leishmania (Leishmania) amazonensis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Leishmania tropica: cysteine proteases are essential for growth and pathogenicity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Leishmania (Leishmania) amazonensis: differential expression of proteinases and cell-surface polypeptides in avirulent and virulent promastigotes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Genomic organization and functional expression of differentially regulated cysteine protease genes of Leishmania donovani complex

31 August 2018

1 reference

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Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction

31 August 2018

1 reference

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Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana.

31 August 2018

1 reference

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The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

The major surface glycoprotein (gp63) from Leishmania major and Leishmania donovani cleaves CD4 molecules on human T cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

Characterizationof Leishmania (Viannia) braziliensismembrane microdomains, and their role in macrophage infectivity

31 August 2018

1 reference

https://api.crossref.org/works/10.1186/1756-3305-5-160

Effect of LACK and KMP11 on IFN-gamma Production by Peripheral Blood Mononuclear Cells from Cutaneous and Mucosal Leishmaniasis Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/1756-3305-5-160

Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/1756-3305-5-160

Characterization of the cellular immune response in American cutaneous leishmaniasis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436776

The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases

3 December 2018

1 reference

https://api.crossref.org/works/10.1186/1756-3305-5-160

21 January 2018

Cutaneous leishmaniasis

1 reference

12 December 2020

Classification of peptidases

1 reference

12 December 2020

Down-regulation of gp63 level in Leishmania amazonensis promastigotes reduces their infectivity in BALB/c mice

1 reference

12 December 2020

Cathepsin B-like cysteine proteases of Leishmania mexicana

1 reference

12 December 2020

Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells

1 reference

12 December 2020

Evidence that the major surface proteins of three Leishmania species are structurally related

1 reference

12 December 2020

Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta

1 reference

12 December 2020

Tegumentary and visceral leishmaniases in Brazil: emerging anthropozoonosis and possibilities for their control

1 reference

12 December 2020

Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression

1 reference

12 December 2020

The major surface protein of Leishmania promastigotes is a protease

1 reference

12 December 2020

Leishmania mexicana: binding of promastigotes to type I collagen

1 reference

12 December 2020

Topical synthetic inhibitor of matrix metalloproteinases delays epidermal regeneration of human wounds

1 reference

12 December 2020

Secreted proteophosphoglycan of Leishmania mexicana amastigotes activates complement by triggering the mannan binding lectin pathway

1 reference

12 December 2020

Leishmania mexicana: identification and characterization of an aspartyl proteinase activity

1 reference

12 December 2020

Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotes

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12 December 2020

TGF-beta-associated enhanced susceptibility to leishmaniasis following intramuscular vaccination of mice with Leishmania amazonensis antigens

1 reference

12 December 2020

Phagocytosis of Leishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production

1 reference

12 December 2020

Cellular localization and expression of gp63 homologous metalloproteases in Leishmania (Viannia) braziliensis strains

1 reference

12 December 2020

Identifiers

DOI

10.1186/1756-3305-5-160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

22871236

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22871236 AND SRC:MED&resulttype=core&format=json