Functional impact and prevalence of polymorphisms involved in the hepatic glucuronidation of valproic acid (Q38030052)

27 August 2017

title

Functional impact and prevalence of polymorphisms involved in the hepatic glucuronidation of valproic acid (English)

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27 August 2017

author name string

Dimitrios Chatzistefanidis

1

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27 August 2017

Ioannis Georgiou

2

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27 August 2017

Athanassios P Kyritsis

3

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27 August 2017

Sofia Markoula

4

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27 August 2017

publication date

1 July 2012

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27 August 2017

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27 August 2017

volume

13

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27 August 2017

issue

9

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27 August 2017

page(s)

1055-1071

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Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells

27 August 2017

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Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

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Genomic organization of the UGT2b gene cluster on human chromosome 4q13.

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Cloning and characterization of a canine UDP-glucuronosyltransferase

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Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms

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Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

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Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.

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Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

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Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

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Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

21 January 2018

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

21 January 2018

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Association of genetic variants in six candidate genes with valproic acid therapy optimization.

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Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

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Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

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The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases

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Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects

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Predicting response to lithium in mood disorders: role of genetic polymorphisms

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Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

21 January 2018

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A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine

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Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

21 January 2018

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Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

21 January 2018

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UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

21 January 2018

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Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y).

21 January 2018

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Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.

21 January 2018

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Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites

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Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis

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Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

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UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese

21 January 2018

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Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations

21 January 2018

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Genetic Variations in UDP-glucuronosyltransferase 2B7 Gene (UGT2B7) in a Korean Population

21 January 2018

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cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3

21 January 2018

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Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity

21 January 2018

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A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.

21 January 2018

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Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

21 January 2018

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Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes

21 January 2018

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UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation

21 January 2018

1 reference

Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants

21 January 2018

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Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients

21 January 2018

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The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

21 January 2018

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Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants

21 January 2018

1 reference

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

21 January 2018

1 reference

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

21 January 2018

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Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients

21 January 2018

1 reference

Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9).

21 January 2018

1 reference

Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population

21 January 2018

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Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.

21 January 2018

1 reference

Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/PGS.12.78

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27 August 2017

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