Metallostasis and amyloid β-degrading enzymes. (Q38029514)

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9 February 2020

title

Metallostasis and amyloid β-degrading enzymes (English)

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9 February 2020

1

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9 February 2020

Maria Laura Giuffrida

2

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9 February 2020

Enrico Rizzarelli

3

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9 February 2020

author name string

Giuseppe Grasso

1

1 reference

27 August 2017

Maria Laura Giuffrida

2

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27 August 2017

Enrico Rizzarelli

3

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27 August 2017

publication date

1 August 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870 AND SRC:MED&resulttype=core&format=json

9 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832870 AND SRC:MED&resulttype=core&format=json

9 February 2020

volume

4

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9 February 2020

issue

9

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9 February 2020

page(s)

937-949

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

9 February 2020

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Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease

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Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer’s disease?

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

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Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

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Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening

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Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au (111) surfaces monitored by ESI-MS.

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In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases

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Effect of neurotoxic metal ions in vitro on proteolytic enzyme activities in human cerebral cortex

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Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

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A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

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New evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions

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Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

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Kinetic analysis of beta-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing

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Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue

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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

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Affinity of Cu for the copper-binding domain of the amyloid-β peptide of Alzheimer's disease.

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Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH.

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The aggregated state of amyloid-beta peptide in vitro depends on Cu2 ion concentration.

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity

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NMR reveals anomalous copper(II) binding to the amyloid Abeta peptide of Alzheimer's disease

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Cu(2 ) Inhibits the Aggregation of Amyloid beta-Peptide(1-42) in vitro We thank JEOL for the AFM measurement. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports, and Culture, and a Grant from "R

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New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

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The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils

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Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

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Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

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Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn 2 as cofactor

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Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal center.

21 January 2018

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Neprilysin and amyloid beta peptide degradation

21 January 2018

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Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme

21 January 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

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Hyperinsulinemia and risk of Alzheimer disease

21 January 2018

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Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

21 January 2018

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AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin

21 January 2018

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Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme

21 January 2018

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

21 January 2018

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Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme

21 January 2018

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

21 January 2018

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21 January 2018

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How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin

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Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.

21 January 2018

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Metal ions affect insulin-degrading enzyme activity.

21 January 2018

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The insulysin (insulin degrading enzyme) enigma

21 January 2018

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Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

21 January 2018

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Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

21 January 2018

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Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

21 January 2018

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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

21 January 2018

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beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease

21 January 2018

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Poly-N-methylated amyloid beta-peptide (Abeta) C-terminal fragments reduce Abeta toxicity in vitro and in Drosophila melanogaster.

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Abeta(31-35) peptide induce apoptosis in PC 12 cells: contrast with Abeta(25-35) peptide and examination of underlying mechanisms.

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Targeted hydrolysis of Beta-amyloid with engineered antibody fragment

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Alzheimer′s Disease and Metals: A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling

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Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species

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Effect of transition metals in synaptic damage induced by amyloid beta peptide

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Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling.

21 January 2018

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

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Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

21 January 2018

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Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy

21 January 2018

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Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

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The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

21 January 2018

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Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

21 January 2018

1 reference

Copper and Alzheimer's disease.

21 January 2018

1 reference

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

21 January 2018

1 reference

Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

21 January 2018

1 reference

New and evolving concepts in the neurotoxicology of lead

21 January 2018

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In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin

21 January 2018

1 reference

Oxidative stress signalling in Alzheimer's disease

21 January 2018

1 reference

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

21 January 2018

1 reference

Calcium dyshomeostasis in white matter pathology

21 January 2018

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Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease

21 January 2018

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Intracellular calcium signalling in Alzheimer's disease

21 January 2018

1 reference

Amyloid beta protein (1-40) forms calcium-permeable, Zn2 -sensitive channel in reconstituted lipid vesicles

21 January 2018

1 reference

In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

1 reference

Aluminum modulation of proteolytic activities

21 January 2018

1 reference

Therapeutic strategies of Alzheimer's disease through manipulation of A? metabolism: a focus on A?-degrading peptidase, neprilysin

21 January 2018

1 reference

Investigations of the molecular mechanism of metal-induced Abeta (1-40) amyloidogenesis

21 January 2018

1 reference

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

21 January 2018

1 reference