The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies (Q38028791)

27 August 2017

title

The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies (English)

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27 August 2017

1

Emmanouil Fokas

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27 August 2017

W Gillies McKenna

2

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27 August 2017

Ruth J Muschel

series ordinal

3

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27 August 2017

publication date

1 December 2012

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Cancer and Metastasis Reviews

27 August 2017

published in

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27 August 2017

volume

31

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27 August 2017

issue

3-4

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27 August 2017

page(s)

823-842

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The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines

27 August 2017

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Drug resistance and the solid tumor microenvironment

21 January 2018

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Tumor hypoxia: its impact on cancer therapy

21 January 2018

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Hypoxic Stress Proteins: Survival of the Fittest

21 January 2018

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Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

21 January 2018

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21 January 2018

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21 January 2018

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Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting

21 January 2018

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Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS).

21 January 2018

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Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program

21 January 2018

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Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution

21 January 2018

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Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

21 January 2018

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Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.

21 January 2018

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Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

21 January 2018

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Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

21 January 2018

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Is vasculogenesis crucial for the regrowth of irradiated tumours?

21 January 2018

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Delta-like ligand 4-notch blockade and tumor radiation response

21 January 2018

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The pathology of ionizing radiation as defined by morphologic patterns.

21 January 2018

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Irradiation-dependent effects on tumor perfusion and endogenous and exogenous hypoxia markers in an A549 xenograft model

21 January 2018

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Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

21 January 2018

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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

21 January 2018

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Radiation enhancement of metastasis: a review

21 January 2018

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Microenvironment-induced cancer metastasis

21 January 2018

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Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis

21 January 2018

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Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways

21 January 2018

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Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions

21 January 2018

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Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer

21 January 2018

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The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products

21 January 2018

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Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy.

21 January 2018

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CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.

21 January 2018

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Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor

21 January 2018

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Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H.

21 January 2018

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Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

21 January 2018

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Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

21 January 2018

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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

21 January 2018

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Drug penetration in solid tumours

21 January 2018

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Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification

21 January 2018

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

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Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.

21 January 2018

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High interstitial fluid pressure - an obstacle in cancer therapy

21 January 2018

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The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

21 January 2018

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Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.

21 January 2018

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A tense situation: forcing tumour progression

21 January 2018

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The universal dynamics of tumor growth

21 January 2018

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Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model

21 January 2018

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21 January 2018

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Disrupting tumour blood vessels

21 January 2018

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21 January 2018

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Targeting VEGF-A to treat cancer and age-related macular degeneration

21 January 2018

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21 January 2018

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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

21 January 2018

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Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

21 January 2018

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21 January 2018

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Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples

21 January 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

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21 January 2018

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21 January 2018

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Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy

21 January 2018

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Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras

21 January 2018

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

21 January 2018

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21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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21 January 2018

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The phosphoinositide 3-kinase pathway

21 January 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

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High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

21 January 2018

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K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis

21 January 2018

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21 January 2018

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Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice

21 January 2018

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H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors

21 January 2018

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21 January 2018

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Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

21 January 2018

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Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells

21 January 2018

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Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism

21 January 2018

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Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

21 January 2018

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Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione

21 January 2018

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Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis

21 January 2018

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Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells

21 January 2018

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Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma

21 January 2018

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Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression

21 January 2018

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PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis

21 January 2018

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The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

21 January 2018

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Microvascular patterning is controlled by fine-tuning the Akt signal

21 January 2018

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis

21 January 2018

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

21 January 2018

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Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

21 January 2018

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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

21 January 2018

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Tumor vascular changes mediated by inhibition of oncogenic signaling

21 January 2018

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Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability

21 January 2018

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Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents

21 January 2018

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Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis

21 January 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

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Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fr

21 January 2018

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Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy

21 January 2018

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Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status

21 January 2018

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Tumour biology: herceptin acts as an anti-angiogenic cocktail.

21 January 2018

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Endogenous Myc maintains the tumor microenvironment

21 January 2018

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The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts

21 January 2018

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Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

21 January 2018

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Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: importance of optimal scheduling to exploit the 'normalization' window of the tumor vasculature

21 January 2018

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Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation

21 January 2018

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HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

21 January 2018

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Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma

21 January 2018

1 reference

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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Modulation of the Tumor Microvasculature by Phosphoinositide-3 Kinase Inhibition Increases Doxorubicin Delivery In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Vascular toxicity of antineoplastic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Exploring the role of cancer stem cells in radioresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

A perivascular niche for brain tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Cancer stem cells as a predictive factor in radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S10555-012-9394-4

10.1007/S10555-012-9394-4

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1048578277

0 references

1 reference