Emerging tools for erectile dysfunction: a role for regenerative medicine. (Q38028739)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22824778 AND SRC:MED&resulttype=core&format=json

8 February 2020

title

Emerging tools for erectile dysfunction: a role for regenerative medicine (English)

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8 February 2020

main subject

regenerative medicine

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1 reference

1

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8 February 2020

Maarten Albersen

5

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8 February 2020

author name string

Frank Van der Aa

2

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8 February 2020

Trinity J Bivalacqua

3

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8 February 2020

Petter Hedlund

4

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8 February 2020

language of work or name

English

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publication date

24 July 2012

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8 February 2020

published in

Nature Reviews Urology

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8 February 2020

volume

9

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8 February 2020

issue

9

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8 February 2020

page(s)

520-536

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The future of the oral pharmacotherapy of male erectile dysfunction: things to come

8 February 2020

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Intracavernous delivery of synthetic angiopoietin-1 protein as a novel therapeutic strategy for erectile dysfunction in the type II diabetic db/db mouse.

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Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat.

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Insulin-like growth factor-1 restores erectile function in aged rats: modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity

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Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway

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Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction

21 January 2018

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Inhibition of Interleukin-6 Attenuates Erectile Dysfunction in a Rat Model of Nerve-Sparing Radical Prostatectomy

21 January 2018

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FK506 and rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury.

21 January 2018

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The effect of FK1706 on erectile function following bilateral cavernous nerve crush injury in a rat model

21 January 2018

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Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: new experimental paradigms

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Immunophilin ligand FK506 is neuroprotective for penile innervation

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Erectile dysfunction management for the future

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Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction

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hMaxi-K gene transfer in males with erectile dysfunction: results of the first human trial.

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Emerging gene and stem cell therapies for the treatment of erectile dysfunction

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Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase

21 January 2018

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Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction

21 January 2018

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Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury

21 January 2018

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Gene therapy as future treatment of erectile dysfunction

21 January 2018

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Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction

21 January 2018

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Nitric oxide synthase gene transfer for erectile dysfunction in a rat model

21 January 2018

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Nitric oxide synthase gene therapy for erectile dysfunction: comparison of plasmid, adenovirus, and adenovirus-transduced myoblast vectors

21 January 2018

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Protein inhibitor of nitric oxide synthase (NOS) and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOS.

21 January 2018

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Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat.

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Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha

21 January 2018

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Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits

21 January 2018

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Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte

21 January 2018

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The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia

21 January 2018

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Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury

21 January 2018

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Improvement in erectile dysfunction after neurotrophic factor gene therapy in diabetic rats

21 January 2018

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Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation

21 January 2018

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Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

21 January 2018

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Molecular and biological properties of vascular endothelial growth factor

21 January 2018

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Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia

21 January 2018

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Vascular endothelial growth factor (VEGF) gene therapy using a nonviral gene delivery system improves erectile function in a diabetic rat model

21 January 2018

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats

21 January 2018

1 reference

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Combined Strategy of Mesenchymal Stem Cell Injection With Vascular Endothelial Growth Factor Gene Therapy for the Treatment of Diabetes‐Associated Erectile Dysfunction

21 January 2018

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Diabetes, oxidative stress, molecular mechanism, and cardiovascular disease--an overview.

21 January 2018

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Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy

21 January 2018

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats.

21 January 2018

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Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

21 January 2018

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RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction

21 January 2018

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Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat.

21 January 2018

1 reference

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Gene therapy for erectile dysfunction: fact or fiction?

21 January 2018

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Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo.

21 January 2018

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The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo.

21 January 2018

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Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat.

21 January 2018

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Gene therapy in the management of erectile dysfunction (ED): past, present, and future.

21 January 2018

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Multipotent stromal cell therapy for cavernous nerve injury-induced erectile dysfunction.

21 January 2018

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The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury

21 January 2018

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Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury

21 January 2018

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Stem cell paracrine actions and tissue regeneration

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Adipose tissue-derived stem cells secrete CXCL5 cytokine with neurotrophic effects on cavernous nerve regeneration

21 January 2018

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Tracking intracavernously injected adipose-derived stem cells to bone marrow

21 January 2018

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Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells

21 January 2018

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Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat.

21 January 2018

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Transplantation of Muscle-Derived Stem Cells into the Corpus Cavernosum Restores Erectile Function in a Rat Model of Cavernous Nerve Injury

21 January 2018

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Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo

21 January 2018

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Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices

21 January 2018

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Construction of cavernosum smooth muscle using umbilical artery smooth muscle cells seeded on acellular corporal collagen matrices

21 January 2018

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Bioengineered corporal tissue for structural and functional restoration of the penis

21 January 2018

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Randomized phase II trial evaluation of erectile function after attempted unilateral cavernous nerve-sparing retropubic radical prostatectomy with versus without unilateral sural nerve grafting for clinically localized prostate cancer.

21 January 2018

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Nerve replacement strategies for cavernous nerves.

21 January 2018

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Cavernous nerve reconstruction with a biodegradable conduit graft and collagen sponge in the rat.

21 January 2018

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Cavernous nerve regeneration by biodegradable alginate gel sponge sheet placement without sutures

21 January 2018

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SCHWANN CELL SEEDED GUIDANCE TUBES RESTORE ERECTILE FUNCTION AFTER ABLATION OF CAVERNOUS NERVES IN RATS

21 January 2018

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GDNF-transduced Schwann cell grafts enhance regeneration of erectile nerves

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Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells

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Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers

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Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat.

21 January 2018

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Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats

21 January 2018

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Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Effect of HO-1 cDNA-liposome complex transfer on erectile signalling of aged rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells

21 January 2018

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction.

21 January 2018

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Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction.

21 January 2018

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NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence

21 January 2018

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Molecular mechanisms for the regulation of penile smooth muscle contractility

31 March 2020

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IGF-I and TGF-beta2 have a key role on regeneration of nitric oxide synthase (NOS)-containing nerves after cavernous neurotomy in rats

31 March 2020

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The role of growth factor on regeneration of nitric oxide synthase (NOS)--containing nerves after cavernous neurotomy in the rats

31 March 2020

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Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radical prostatectomy.

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Improvement of Erectile Function in Diabetic Rats by Insulin: Possible Role of the Insulin-Like Growth Factor System1

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Editorial comment on: Smooth-muscle-specific gene transfer with the human maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

The first human trial for gene transfer therapy for the treatment of erectile dysfunction: preliminary results

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Gene Therapy With an Erythropoietin Enhancer—Mediated, Hypoxia‐Inducible Gene Expression System in the Corpus Cavernosum of Mice With High‐Cholesterol Diet‐Induced Erectile Dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Smooth-muscle-specific gene transfer with the human maxi-k channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Intracavernous Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Restores Erectile Function of Streptozocin-Induced Diabetic Rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Injection of skeletal muscle-derived cells into the penis improves erectile function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Construction of tissue-engineered corpus cavernosum with muscle-derived stem cells and transplantation in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Editorial comment on: Surgical treatment of Peyronie's disease by plaque incision and grafting with buccal mucosa

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Tissue engineering for penile surgery: comparative study of noncellular and cell-seeded synthetic grafts for tunica albuginea replacement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Surgical Option for the Correction of Peyronie's Disease: An Autologous Tissue-Engineered Endothelialized Graft

31 March 2020

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https://api.crossref.org/works/10.1038/NRUROL.2012.143

Interposition of sural nerve restores function of cavernous nerves resected during radical prostatectomy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRUROL.2012.143

Gene transfer of the K(ATP) channel restores age-related erectile dysfunction in rats

31 March 2020

1 reference

12 December 2020

Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats

1 reference

12 December 2020

Growth hormone enhances regeneration of nitric oxide synthase-containing penile nerves after cavernous nerve neurotomy in rats

1 reference

12 December 2020

NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence

1 reference

12 December 2020

Intracorporal injection ofhSlocDNA in rats produces physiologically relevant alterations in penile function

1 reference

12 December 2020

The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence

1 reference

12 December 2020

Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase

1 reference

12 December 2020

Re: Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. M. Kendirci, L. Trost, B. Bakondi, M. J.

1 reference

12 December 2020

Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction

1 reference

12 December 2020

Reconstitution of human corporal smooth muscle and endothelial cells in vivo

1 reference

12 December 2020

Characterization of K currents in cultured human corporal smooth muscle cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRUROL.2012.143

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22824778 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 February 2020

1015931370

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22824778 AND SRC:MED&resulttype=core&format=json