Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory. (Q38026984)

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8 February 2020

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6 April 2021

Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory (English)

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8 February 2020

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Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

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A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.

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Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid

6 September 2017

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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

6 September 2017

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

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Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

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Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

6 September 2017

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Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

6 September 2017

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6 September 2017

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Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

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6 September 2017

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Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

6 September 2017

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Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

6 September 2017

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

6 September 2017

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Memory impairment in transgenic Alzheimer mice requires cellular prion protein

6 September 2017

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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

6 September 2017

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The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

6 September 2017

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Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases

6 September 2017

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Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration.

6 September 2017

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The functional neurophysiology of the amyloid precursor protein (APP) processing pathway

6 September 2017

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

6 September 2017

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Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

6 September 2017

1 reference

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Cognitive effects of cell-derived and synthetically derived Aβ oligomers

6 September 2017

1 reference

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Prion-like mechanisms in neurodegenerative diseases

6 September 2017

1 reference

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Controlled in situ preparation of A beta(1-42) oligomers from the isopeptide "iso-A beta(1-42)", physicochemical and biological characterization

6 September 2017

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Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure

6 September 2017

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Prion neurodegeneration: starts and stops at the synapse

6 September 2017

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Prion protein and Alzheimer disease

6 September 2017

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Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life

6 September 2017

1 reference

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

6 September 2017

1 reference

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Properties and pathogenicity of prion-derived peptides

6 September 2017

1 reference

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Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins

6 September 2017

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

6 September 2017

1 reference

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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

6 September 2017

1 reference

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Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease

6 September 2017

1 reference

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Structural classification of toxic amyloid oligomers

6 September 2017

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Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo.

6 September 2017

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

6 September 2017

1 reference

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Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

6 September 2017

1 reference

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Cellular pathogenesis in prion diseases.

6 September 2017

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Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation

6 September 2017

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Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

6 September 2017

1 reference

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Synaptic plasticity, memory and the hippocampus: a neural network approach to causality.

6 September 2017

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Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

6 September 2017

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

6 September 2017

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A network dysfunction perspective on neurodegenerative diseases

6 September 2017

1 reference

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Physiological roles for amyloid beta peptides

6 September 2017

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A specific amyloid-beta protein assembly in the brain impairs memory

6 September 2017

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Opinion: What is the role of protein aggregation in neurodegeneration?

6 September 2017

1 reference

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

6 September 2017

1 reference

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Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

6 September 2017

1 reference

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Long-Term Potentiation and Memory

6 September 2017

1 reference

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

6 September 2017

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

6 September 2017

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Alzheimer's disease is a synaptic failure

6 September 2017

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Conformational Abs recognizing a generic amyloid fibril epitope

6 September 2017

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Transgenic models of prion disease.

6 September 2017

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Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo.

6 September 2017

1 reference

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

6 September 2017

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

6 September 2017

1 reference

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Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease

6 September 2017

1 reference

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

6 September 2017

1 reference

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Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils

6 September 2017

1 reference

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Potent amyloidogenicity and pathogenicity of Aβ43.

6 September 2017

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Effects of an exogenous beta-amyloid peptide on retention for spatial learning.

6 September 2017

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Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration.

6 September 2017

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Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

The prion protein as a receptor for amyloid-beta.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Oligomers of the prion protein fragment 106-126 are likely assembled from beta-hairpins in solution, and methionine oxidation inhibits assembly without altering the peptide's monomeric conformation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

CNS amyloid proteins in neurodegenerative diseases.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Intraneuronally injected amyloid β inhibits long-term potentiation in rat hippocampal slices

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

PrP antibodies do not trigger mouse hippocampal neuron apoptosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

α-synuclein induced synapse damage is enhanced by amyloid-β1-42

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

A physiological role for amyloid-beta protein:enhancement of learning and memory

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Beta-amyloid monomers are neuroprotective.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Amyloid beta mediates memory formation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Neurotoxicity of a prion protein fragment

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502131

Structural Properties and Dynamic Behavior of Nonfibrillar Oligomers Formed by PrP(106−126)

31 August 2018

1 reference

12 December 2020

N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis

1 reference

12 December 2020

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

12 December 2020

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

1 reference

12 December 2020

Identifiers

DOI

10.1186/1756-6606-5-25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22805374 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22805374 AND SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

22805374

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22805374 AND SRC:MED&resulttype=core&format=json