The genetics of multiple sclerosis: an up-to-date review (Q38020959)

23 June 2018

title

The genetics of multiple sclerosis: an up-to-date review (English)

1 reference

23 June 2018

main subject

multiple sclerosis

0 references

author

Pierre-Antoine Gourraud

1

Pierre-Antoine Gourraud

0 references

Stephen L. Hauser

3

Stephen L Hauser

1 reference

23 June 2018

Hanne F Harbo

2

Hanne F Harbo

1 reference

23 June 2018

Sergio E Baranzini

4

Sergio E Baranzini

1 reference

23 June 2018

PMC publication ID

5967887

language of work or name

1 reference

1 July 2012

1 reference

23 June 2018

published in

Immunological Reviews

1 reference

23 June 2018

volume

248

1 reference

23 June 2018

issue

1

1 reference

23 June 2018

page(s)

87-103

1 reference

23 June 2018

DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP).

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The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4 T cell proliferation

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25 June 2018

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Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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Role of differential expression of interferon receptor isoforms on the response of multiple sclerosis patients to therapy with interferon beta.

25 June 2018

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25 June 2018

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25 June 2018

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HLA B*44: protective effects in MS susceptibility and MRI outcome measures

25 June 2018

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Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

25 June 2018

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A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

25 June 2018

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Refining the association of MHC with multiple sclerosis in African Americans

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

25 June 2018

1 reference

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Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

25 June 2018

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A CD8 T cell transcription signature predicts prognosis in autoimmune disease

25 June 2018

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25 June 2018

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Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

25 June 2018

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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

25 June 2018

1 reference

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Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA

25 June 2018

1 reference

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IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Detecting shared pathogenesis from the shared genetics of immune-related diseases

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Interferon-beta responders and non-responders. A biological approach

25 June 2018

1 reference

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Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Gene expression analysis of interferon-beta treatment in multiple sclerosis

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Pharmacogenomics of interferon-beta therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients

25 June 2018

1 reference

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Protein networks in disease

25 June 2018

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

25 June 2018

1 reference

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Risk alleles for multiple sclerosis identified by a genomewide study

25 June 2018

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Moving toward a system genetics view of disease

25 June 2018

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HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis

25 June 2018

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The human disease network

25 June 2018

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25 June 2018

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A second major histocompatibility complex susceptibility locus for multiple sclerosis

25 June 2018

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Systems-based medicine approaches to understand and treat complex diseases. The example of multiple sclerosis

25 June 2018

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Functional epistasis on a common MHC haplotype associated with multiple sclerosis

25 June 2018

1 reference

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Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.

25 June 2018

1 reference

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Genetics of autoimmune myasthenia gravis: the multifaceted contribution of the HLA complex.

25 June 2018

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A high-density screen for linkage in multiple sclerosis

25 June 2018

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Transcription-based prediction of response to IFNbeta using supervised computational methods

25 June 2018

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Biological activity of interferon betas in patients with multiple sclerosis is affected by treatment regimen and neutralising antibodies.

25 June 2018

1 reference

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Network biology: understanding the cell's functional organization

25 June 2018

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Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

25 June 2018

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25 June 2018

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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

25 June 2018

1 reference

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Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis

25 June 2018

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HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.

25 June 2018

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On the allelic spectrum of human disease

25 June 2018

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HLA-DR15 is associated with lower age at onset in multiple sclerosis

25 June 2018

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Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease

25 June 2018

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DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population

25 June 2018

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Invited anniversary review: HLA associated diseases

25 June 2018

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A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

25 June 2018

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A polymorphic DNA marker genetically linked to Huntington's disease

25 June 2018

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HL-A antigens and multiple sclerosis.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

B-lymphocyte alloantigens associated with multiple sclerosis

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Rare variants in the CYP27B1 gene are associated with multiple sclerosis.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Implication of the Toll-like receptor 4 pathway in the response to interferon-β in multiple sclerosis.

31 August 2018

1 reference

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Predictive, personalized, preventive, participatory (P4) cancer medicine.

31 August 2018

1 reference

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Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis

31 August 2018

1 reference

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HLA-DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population.

31 August 2018

1 reference

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Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis

31 August 2018

1 reference

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Identification of new sensitive biomarkers for the in vivo response to interferon-beta treatment in multiple sclerosis using DNA-array evaluation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

A network view of disease and compound screening

31 August 2018

1 reference

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HLA-DRB115 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis.

31 August 2018

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Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D.

31 August 2018

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N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.

31 August 2018

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Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami

31 August 2018

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Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

31 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

The HLA locus and multiple sclerosis in Sicily.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Decreased integrin gene expression in patients with MS responding to interferon-beta treatment

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Cigarette smoking and incidence of multiple sclerosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Natural killer cell phenotype and clinical response to interferon-beta therapy in multiple sclerosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Association of HLA class I markers with multiple sclerosis in the Italian and UK population: evidence of two independent protective effects

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

Smoking is a risk factor for multiple sclerosis: a metanalysis

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

A full genome search in multiple sclerosis

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5967887

A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2

3 December 2018

1 reference

12 December 2020

Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis

1 reference

12 December 2020

A genome screen for multiple sclerosis in Sardinian multiplex families

1 reference

12 December 2020

Different HLA DR2-DQw1 haplotypes in Sardinian and northern Italian populations: implications for multiple sclerosis susceptibility

1 reference

12 December 2020

Association of histocompatibility haplotype HLA-A3-B7 with multiple sclerosis

1 reference

12 December 2020

The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients

1 reference

12 December 2020

Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type

1 reference

12 December 2020

Two HLA class I genes independently associated with multiple sclerosis

1 reference

12 December 2020

Sardinian multiple sclerosis is associated with HLA-DR4: a serologic and molecular analysis

1 reference

12 December 2020

Multiple Sclerosis: Association with HL—A3

1 reference

12 December 2020

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group

1 reference

12 December 2020

The HLA‐DQ(α1*0102, β1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA‐DR(α1*01, β1*1501) heterodimer

1 reference

12 December 2020

The major histocompatibility complex and multiple sclerosis: a smoking gun?

1 reference

12 December 2020

Histocompatibility determinants in multiple sclerosis, with special reference to clinical course

1 reference

12 December 2020

Smoking is a risk factor for multiple sclerosis

1 reference

12 December 2020

Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia

1 reference

12 December 2020

Smoking is a risk factor for multiple sclerosis

1 reference

12 December 2020

10.1111/J.1600-065X.2012.01134.X

Identifiers

DOI

1 reference

23 June 2018

PMC publication ID

5967887

1 reference

23 June 2018

PubMed publication ID

22725956

1 reference

23 June 2018