Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. (Q38020618)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22721767 AND SRC:MED&resulttype=core&format=json

5 February 2020

title

Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system (English)

1 reference

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5 February 2020

0 references

1

1 reference

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5 February 2020

5

Lester I Binder

1 reference

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5 February 2020

author name string

Gustavo F Pigino

2

1 reference

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5 February 2020

Scott T Brady

3

1 reference

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5 February 2020

Orly Lazarov

4

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5 February 2020

Gerardo A Morfini

6

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5 February 2020

language of work or name

English

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publication date

19 June 2012

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5 February 2020

published in

Experimental Neurology

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5 February 2020

volume

246

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5 February 2020

page(s)

44-53

1 reference

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The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

5 February 2020

cites work

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Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

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BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer’s Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology

6 September 2017

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Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

6 September 2017

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Alzheimer's disease: the challenge of the second century

6 September 2017

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Amyloid Precursor Protein Processing and Alzheimer's Disease

6 September 2017

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Cytoplasmic dynein in neurodegeneration

6 September 2017

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Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI

6 September 2017

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Molecular signaling how do axons die?

6 September 2017

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Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Convergence of Presenilin- and Tau-Mediated Pathways on Axonal Trafficking and Neuronal Function

6 September 2017

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6 September 2017

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6 September 2017

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Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: a diffusion tensor imaging study.

6 September 2017

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Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment

6 September 2017

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Axonal transport defects in neurodegenerative diseases

6 September 2017

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GSK3: a possible link between beta amyloid peptide and tau protein.

6 September 2017

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Aberrant phosphorylation in the pathogenesis of Alzheimer's disease

6 September 2017

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Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities

6 September 2017

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Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

6 September 2017

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6 September 2017

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Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

6 September 2017

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Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

6 September 2017

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The mechanism of Ca2 -dependent regulation of kinesin-mediated mitochondrial motility

6 September 2017

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The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

6 September 2017

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Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

6 September 2017

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Amyloid precursor protein trafficking, processing, and function

6 September 2017

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

6 September 2017

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Microtubule-associated protein tau in development, degeneration and protection of neurons

6 September 2017

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Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin

6 September 2017

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Conventional kinesin holoenzymes are composed of heavy and light chain homodimers

6 September 2017

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Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice

6 September 2017

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Differential regulation of dynein and kinesin motor proteins by tau

6 September 2017

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The G59S mutation in p150(glued) causes dysfunction of dynactin in mice

6 September 2017

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6 September 2017

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Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

6 September 2017

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Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1

6 September 2017

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

6 September 2017

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In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

6 September 2017

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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

6 September 2017

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

6 September 2017

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Tau phosphorylation, aggregation, and cell toxicity

6 September 2017

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

6 September 2017

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Altered synaptic function in Alzheimer's disease

6 September 2017

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Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

6 September 2017

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Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease

6 September 2017

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Ageing and neuronal vulnerability

6 September 2017

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Genetic analysis of the cytoplasmic dynein subunit families

6 September 2017

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Distal spinal and bulbar muscular atrophy caused by dynactin mutation.

6 September 2017

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Axonal transport defects: a common theme in neurodegenerative diseases

6 September 2017

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Mutations causing neurodegenerative tauopathies

6 September 2017

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Molecular pathways to neurodegeneration

6 September 2017

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

6 September 2017

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Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

6 September 2017

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Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta

6 September 2017

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A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)

6 September 2017

1 reference

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Axon pathology in neurological disease: a neglected therapeutic target

6 September 2017

1 reference

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Tau is essential to beta -amyloid-induced neurotoxicity

6 September 2017

1 reference

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Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

6 September 2017

1 reference

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Current concepts in mild cognitive impairment

6 September 2017

1 reference

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Cytoplasmic dynein subunit heterogeneity: implications for axonal transport

6 September 2017

1 reference

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Approaches to study interactions between kinesin motors and membranes.

6 September 2017

1 reference

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The value of transgenic models for the study of neurodegenerative diseases

6 September 2017

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Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

6 September 2017

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Transneuronal Degeneration in the Spread of Alzheimer's Disease Pathology: Immunohistochemical Evidence for the Transmission of Tau Hyperphosphorylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Immunochemical analysis of kinesin light chain function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Differential phosphorylation in vivo of cytoplasmic dynein associated with anterogradely moving organelles

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Human amyloid-beta1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Copurification of kinesin polypeptides with microtubule-stimulated Mg-ATPase activity and kinetic analysis of enzymatic properties

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

A perspective on neuronal cell death signaling and neurodegeneration

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Strategic involvement of cholinergic pathways and executive dysfunction: Does location of white matter signal hyperintensities matter?

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Diffusion tensor imaging of normal appearing white matter and its correlation with cognitive functioning in mild cognitive impairment and Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Tau binding to microtubules does not directly affect microtubule-based vesicle motility

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Age-dependent axonal degeneration in an Alzheimer mouse model.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Examining the gateway to the limbic system with diffusion tensor imaging: the perforant pathway in dementia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

The extent of axonal loss in the long tracts in hereditary spastic paraplegia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Apolipoprotein E activates Akt pathway in neuro-2a in an isoform-specific manner

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Accumulation of SNAP-25 immunoreactive material in axons of Alzheimerʼs disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3465504

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

3 December 2018

1 reference

12 December 2020

Regulation of kinesin: implications for neuronal development

1 reference

12 December 2020

GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations

1 reference

12 December 2020

Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease

1 reference

12 December 2020

10.1016/J.EXPNEUROL.2012.06.003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22721767 AND SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22721767 AND SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

22721767

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22721767 AND SRC:MED&resulttype=core&format=json