The bromodomain interaction module (Q38019699)

27 August 2017

title

The bromodomain interaction module (English)

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27 August 2017

author

Panagis Filippakopoulos

series ordinal

1

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27 August 2017

Stefan Knapp

2

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language of work or name

English

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publication date

3 May 2012

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27 August 2017

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27 August 2017

volume

586

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27 August 2017

issue

17

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27 August 2017

page(s)

2692-2704

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Preliminary Notes on the Development of the Wings in Normal and Mutant Strains of Drosophila

27 August 2017

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Reading signals on the nucleosome with a new nomenclature for modified histones

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Chromatin modifications and their function

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Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

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Translating the Histone Code

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Activation of chromatin by acetylation of histone side chains

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Histone H4-K16 acetylation controls chromatin structure and protein interactions

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The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

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Regulation of cellular metabolism by protein lysine acetylation

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Acetylation: a regulatory modification to rival phosphorylation?

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Anticancer activities of histone deacetylase inhibitors

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Histone deacetylase inhibitors: molecular mechanisms of action

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Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

21 January 2018

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Rational Therapeutic Combinations with Histone Deacetylase Inhibitors for the Treatment of Cancer

21 January 2018

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Selective inhibition of BET bromodomains

21 January 2018

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Suppression of inflammation by a synthetic histone mimic

21 January 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

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brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

21 January 2018

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Structure and ligand of a histone acetyltransferase bromodomain

21 January 2018

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The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription

21 January 2018

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Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human

21 January 2018

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Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes

21 January 2018

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TIF1gamma, a novel member of the transcriptional intermediary factor 1 family

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structure and function of a human TAFII250 double bromodomain module

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The multi-tasking P-TEFb complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Bromodomains as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Selective recognition of acetylated histones by bromodomain proteins visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Selective recognition of acetylated histones by bromodomains in transcriptional co-activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex

21 January 2018

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CBP and p300: HATs for different occasions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Expression of the Wdr9 gene and protein products during mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Identification of JAK/STAT signalling components by genome-wide RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Histone modifications defining active genes persist after transcriptional and mitotic inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Interaction between acetylated MyoD and the bromodomain of CBP and/or p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

TIF1gamma controls erythroid cell fate by regulating transcription elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

TRIM24 links a non-canonical histone signature to breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

SP100 inhibits ETS1 activity in primary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Regulation of matrix attachment region-dependent, lymphocyte-restricted transcription through differential localization within promyelocytic leukemia nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

A novel family of bromodomain genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

A Poised Chromatin Platform for TGF-β Access to Master Regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

KAP1 controls endogenous retroviruses in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

An acetylation switch in p53 mediates holo-TFIID recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

A unique chromatin signature uncovers early developmental enhancers in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Kinetic analysis of acetylation-dependent Pb1 bromodomain-histone interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Target structure-based discovery of small molecules that block human p53 and CREB binding protein association

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Identification and characterization of PRKCBP1, a candidate RACK-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2012.04.045

10.1016/J.FEBSLET.2012.04.045

21 January 2018

Identifiers

DOI

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27 August 2017

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