Splicing in oncogenesis and tumor suppression (Q38018123)

27 August 2017

title

Splicing in oncogenesis and tumor suppression (English)

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27 August 2017

3

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27 August 2017

Daisuke Kaida

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author name string

Tilman Schneider-Poetsch

series ordinal

2

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27 August 2017

language of work or name

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24 July 2012

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27 August 2017

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27 August 2017

volume

103

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27 August 2017

issue

9

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27 August 2017

page(s)

1611-1616

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Pre-mRNA processing reaches back to transcription and ahead to translation

27 August 2017

cites work

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

21 January 2018

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The spliceosome: design principles of a dynamic RNP machine

21 January 2018

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

NMD: RNA biology meets human genetic medicine

21 January 2018

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Functional consequences of developmentally regulated alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Alternative isoform regulation in human tissue transcriptomes

21 January 2018

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Messenger-RNA-binding proteins and the messages they carry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The SR protein family of splicing factors: master regulators of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

BIN1 is a novel MYC-interacting protein with features of a tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Invasive growth: from development to metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Myelodysplastic syndromes: the complexity of stem-cell diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Frequent pathway mutations of splicing machinery in myelodysplasia

21 January 2018

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Apoptosis: embedded in membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Relevance of Bcl-x expression in different types of endometrial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

21 January 2018

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https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

A target for Src in mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Sam68 exerts separable effects on cell cycle progression and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Neoplastic transformation and tumorigenesis associated with sam68 protein deficiency in cultured murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The RNA-binding protein Sam68 is a multifunctional player in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Vascular endothelial growth factor is a secreted angiogenic mitogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

VEGF-A splicing: the key to anti-angiogenic therapeutics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Structure of a VEGF-VEGF receptor complex determined by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Splicing factor SF3b as a target of the antitumor natural product pladienolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Phase I clinical trials in 56 patients with thyroid cancer: the M. D. Anderson Cancer Center experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Manipulation of alternative splicing by a newly developed inhibitor of Clks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2012.02356.X

New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

21 January 2018

1 reference

12 December 2020

VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

1 reference

12 December 2020

Predominant expression of the long isoform of Bcl-x (Bcl-xL) in human lymphomas

1 reference

12 December 2020

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression

1 reference

12 December 2020

Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression

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12 December 2020

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

1 reference

12 December 2020

Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines.

1 reference

12 December 2020

RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP

1 reference

12 December 2020

Vascular permeability factor, an endothelial cell mitogen related to PDGF

1 reference

12 December 2020

hnRNP proteins and splicing control.

1 reference

12 December 2020

10.1111/J.1349-7006.2012.02356.X

Identifiers

DOI

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27 August 2017

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