Modulators of Na/K-ATPase: a patent review (Q38010820)

26 August 2017

title

Modulators of Na/K-ATPase: a patent review (English)

1 reference

26 August 2017

George A O'Doherty

2

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author name string

Hua-Yu Leo Wang

series ordinal

1

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26 August 2017

language of work or name

English

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publication date

17 May 2012

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Expert Opinion on Therapeutic Patents

26 August 2017

published in

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26 August 2017

volume

22

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26 August 2017

issue

6

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26 August 2017

page(s)

587-605

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Annual review prize lecture. 'All hands to the sodium pump'.

26 August 2017

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Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma

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Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex

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Comparative properties of caveolar and noncaveolar preparations of kidney Na /K -ATPase

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

21 January 2018

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Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets

21 January 2018

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21 January 2018

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Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

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Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization

21 January 2018

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Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors.

21 January 2018

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Treatment of congestive heart failure--current status of use of digitoxin

21 January 2018

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Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity

21 January 2018

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Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

21 January 2018

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Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.

21 January 2018

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Pegylation: a novel process for modifying pharmacokinetics

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UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

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Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.

21 January 2018

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The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells

21 January 2018

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UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

21 January 2018

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Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

21 January 2018

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Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers

21 January 2018

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Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells

21 January 2018

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The digitalis-like steroid hormones: new mechanisms of action and biological significance

21 January 2018

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Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

21 January 2018

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Isolation and structure of a 20,21-epoxybufenolide series from "Ch'an Su".

21 January 2018

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One new bufadienolide from Chinese drug "Chan'Su".

21 January 2018

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21 January 2018

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Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells

21 January 2018

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Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.

21 January 2018

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Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells

21 January 2018

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Bufadienolides and their antitumor activity

21 January 2018

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21 January 2018

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QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).

21 January 2018

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21 January 2018

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Structure-based design and synthesis of novel potent Na ,K -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds

21 January 2018

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17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na( ),K( )-ATPase at the digitalis receptor

21 January 2018

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Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).

21 January 2018

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Regulation of current flow through ryanodine receptors by luminal Ca2 .

21 January 2018

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Modulation of sarcoplasmic reticulum function by Na /K pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride].

21 January 2018

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Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Tria

21 January 2018

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Identification of hydroxyxanthones as Na/K-ATPase ligands

21 January 2018

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Chromenes from the brown alga Sargassum siliquastrum

21 January 2018

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γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer

21 January 2018

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Sargachromanols as inhibitors of Na /K ATPase and isocitrate lyase.

21 January 2018

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21 January 2018

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Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

21 January 2018

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Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.

21 January 2018

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Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata

21 January 2018

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Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

21 January 2018

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2-Methoxy-3,8,9-trihydroxy coumestan: a new synthetic inhibitor of Na ,K -ATPase with an original mechanism of action

21 January 2018

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21 January 2018

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21 January 2018

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Iantherans A and B, unique dimeric polybrominated benzofurans as Na,K-ATPase inhibitors from a marine sponge, Ianthella sp.

21 January 2018

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Aplysiallene, a new bromoallene as an Na, K-ATPase inhibitor from the sea hare, Aplysia kurodai

21 January 2018

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Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection

21 January 2018

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Magnesium lithospermate B possesses inhibitory activity on Na ,K -ATPase and neuroprotective effects against ischemic stroke

21 January 2018

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Magnesium lithospermate B extracted from Salvia miltiorrhiza elevates intracellular Ca(2 ) level in SH-SY5Y cells

21 January 2018

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Active ingredients in Chinese medicines promoting blood circulation as Na /K -ATPase inhibitors

21 January 2018

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Bufadienolides of plant and animal origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543776.2012.690033

The protective effect of magnesium lithospermate B against glucose-induced intracellular oxidative damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543776.2012.690033

10.1517/13543776.2012.690033

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference