Recognition of damaged DNA: structure and dynamic markers (Q38005951)

26 August 2017

title

Recognition of damaged DNA: structure and dynamic markers (English)

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26 August 2017

Markus W Germann

1

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26 August 2017

Christopher N Johnson

series ordinal

2

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26 August 2017

Alexander M Spring

series ordinal

3

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26 August 2017

publication date

9 November 2010

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Medicinal Research Reviews

26 August 2017

published in

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26 August 2017

volume

32

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26 August 2017

issue

3

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26 August 2017

page(s)

659-683

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Instability and decay of the primary structure of DNA

26 August 2017

cites work

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How do DNA repair proteins locate damaged bases in the genome?

21 January 2018

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Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

21 January 2018

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Cockayne syndrome: defective repair of transcription?

21 January 2018

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Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

21 January 2018

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The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

21 January 2018

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Smoking and lung cancer--a new role for an old toxicant?

21 January 2018

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NMR structures of damaged DNA.

21 January 2018

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Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal

21 January 2018

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21 January 2018

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Mechanisms in eukaryotic mismatch repair

21 January 2018

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21 January 2018

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Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means

21 January 2018

1 reference

Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis

21 January 2018

1 reference

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

21 January 2018

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Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates

21 January 2018

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Structure of the human MutSalpha DNA lesion recognition complex

21 January 2018

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Cellular machineries for chromosomal DNA repair.

21 January 2018

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Chromatin challenges during DNA replication and repair

21 January 2018

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The DNA damage response: putting checkpoints in perspective

21 January 2018

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Change of guard at the checkpoint

21 January 2018

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A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification

21 January 2018

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Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

21 January 2018

1 reference

21 January 2018

DNA damage and repair

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Prokaryotic nucleotide excision repair: the UvrABC system.

21 January 2018

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Biochemistry and genetics of eukaryotic mismatch repair

21 January 2018

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Chromosomal stability and the DNA double-stranded break connection

21 January 2018

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Nitrosated peptides and polyamines as endogenous mutagens in O6- alkylguanine-DNA alkyltransferase deficient cells

21 January 2018

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Structure and function of the (A)BC excinuclease of Escherichia coli

21 January 2018

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NMR studies of a DNA containing 8-hydroxydeoxyguanosine

21 January 2018

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Mutagenicity, toxicity and repair of DNA base damage induced by oxidation

21 January 2018

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21 January 2018

Oxidative Decay of DNA

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Maintenance of mitochondrial DNA integrity: repair and degradation

21 January 2018

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Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

21 January 2018

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Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells

21 January 2018

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A unified theory of gene expression

21 January 2018

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Nucleosome remodeling by hMSH2-hMSH6.

21 January 2018

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Methyl CpG-binding proteins and transcriptional repression

21 January 2018

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Preferential targeting of oxidative base damage to internucleosomal DNA.

21 January 2018

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DNA base excision repair of uracil residues in reconstituted nucleosome core particles

21 January 2018

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DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

21 January 2018

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The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine

21 January 2018

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Nucleosome structure and repair of N-methylpurines in the GAL1-10 genes of Saccharomyces cerevisiae

21 January 2018

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Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions

21 January 2018

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Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme

21 January 2018

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Nucleosome structure and positioning modulate nucleotide excision repair in the non-transcribed strand of an active gene

21 January 2018

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Lux ex tenebris: nucleotide resolution DNA repair and nucleosome mapping

21 January 2018

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Nucleotide excision repair and chromatin remodeling

21 January 2018

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Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair

21 January 2018

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Base excision repair in nucleosome substrates

21 January 2018

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Dissecting transcription-coupled and global genomic repair in the chromatin of yeast GAL1-10 genes

21 January 2018

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Mechanisms and functions of DNA mismatch repair

21 January 2018

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The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch

21 January 2018

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Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair

21 January 2018

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Evidence that nucleosomes inhibit mismatch repair in eukaryotic cells

21 January 2018

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Human DNA glycosylases involved in the repair of oxidatively damaged DNA.

21 January 2018

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DNA repair in mammalian cells: Base excision repair: the long and short of it.

21 January 2018

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DNA glycosylase recognition and catalysis

21 January 2018

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Oxidative DNA damage repair in mammalian cells: a new perspective

21 January 2018

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Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.

21 January 2018

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Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors

21 January 2018

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Ape1 abasic endonuclease activity is regulated by magnesium and potassium concentrations and is robust on alternative DNA structures

21 January 2018

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Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?

21 January 2018

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Endoribonuclease activity of human apurinic/apyrimidinic endonuclease 1 revealed by a real-time fluorometric assay.

21 January 2018

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Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

21 January 2018

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Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae

21 January 2018

1 reference

21 January 2018

Going APE over ref-1.

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The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

21 January 2018

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Alpha-deoxyadenosine, a major anoxic radiolysis product of adenine in DNA, is a substrate for Escherichia coli endonuclease IV.

21 January 2018

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Alternative nucleotide incision repair pathway for oxidative DNA damage

21 January 2018

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Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.

21 January 2018

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Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

21 January 2018

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Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase

21 January 2018

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Different DNA repair strategies to combat the threat from 8-oxoguanine.

21 January 2018

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Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

21 January 2018

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The C-terminal Lysine of Ogg2 DNA Glycosylases is a Major Molecular Determinant for Guanine/8-Oxoguanine Distinction

21 January 2018

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Activation of human MutS homologs by 8-oxo-guanine DNA damage

21 January 2018

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Clostridium acetobutylicum 8-oxoguanine DNA glycosylase (Ogg) differs from eukaryotic Oggs with respect to opposite base discrimination

21 January 2018

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Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase

21 January 2018

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Direct visualization of a DNA glycosylase searching for damage

21 January 2018

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Electrostatic potential maps of damaged DNA studied by image analysis tools. 8-Oxoguanine and abasic site lesions

21 January 2018

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Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.

21 January 2018

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Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

21 January 2018

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Entrapment and Structure of an Extrahelical Guanine Attempting to Enter the Active Site of a Bacterial DNA Glycosylase, MutM

21 January 2018

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21 January 2018

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Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage

21 January 2018

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Lessons learned from structural results on uracil-DNA glycosylase

21 January 2018

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Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

21 January 2018

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Uracil in DNA--occurrence, consequences and repair

21 January 2018

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Enzymatic capture of an extrahelical thymine in the search for uracil in DNA

21 January 2018

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Role of base flipping in specific recognition of damaged DNA by repair enzymes.

21 January 2018

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Linear free energy correlations for enzymatic base flipping: how do damaged base pairs facilitate specific recognition?

21 January 2018

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Dynamic opening of DNA during the enzymatic search for a damaged base

21 January 2018

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Structures of apurinic and apyrimidinic sites in duplex DNAs

21 January 2018

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Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites

21 January 2018

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Refined solution structure of a DNA heteroduplex containing an aldehydic abasic site

21 January 2018

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Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformation

21 January 2018

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DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics

21 January 2018

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New insights into the structure of abasic DNA from molecular dynamics simulations

21 January 2018

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Damage increases the flexibility of duplex DNA

21 January 2018

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Influence of abasic and anucleosidic sites on the stability, conformation, and melting behavior of a DNA duplex: correlations of thermodynamic and structural data

21 January 2018

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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

21 January 2018

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Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vectors

21 January 2018

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Solution structure of a DNA duplex containing an alpha-anomeric adenosine: insights into substrate recognition by endonuclease IV.

21 January 2018

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DNA mismatch repair: functions and mechanisms

21 January 2018

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DNA mismatch repair: molecular mechanism, cancer, and ageing

21 January 2018

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Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation

21 January 2018

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Deciphering the mismatch recognition cycle in MutS and MSH2-MSH6 using normal-mode analysis

21 January 2018

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Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL.

21 January 2018

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Conformational change in MSH2-MSH6 upon binding DNA coupled to ATPase activity

21 January 2018

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The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch

21 January 2018

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The Phe-X-Glu DNA binding motif of MutS. The role of hydrogen bonding in mismatch recognition

21 January 2018

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Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

21 January 2018

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DNA mismatch repair: MutS structures bound to mismatches.

21 January 2018

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Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

21 January 2018

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A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition

21 January 2018

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Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair

21 January 2018

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DNA repair: models for damage and mismatch recognition

21 January 2018

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Assignments of 31P NMR resonances in oligodeoxyribonucleotides: origin of sequence-specific variations in the deoxyribose phosphate backbone conformation and the 31P chemical shifts of double-helical nucleic acids

21 January 2018

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Structural differences in the NOE-derived structure of G-T mismatched DNA relative to normal DNA are correlated with differences in (13)C relaxation-based internal dynamics

21 January 2018

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Sequence dependence of base-pair opening in a DNA dodecamer containing the CACA/GTGT sequence motif

21 January 2018

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Signals for TBP/TATA box recognition

21 January 2018

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APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

21 January 2018

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Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex

21 January 2018

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Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults

21 January 2018

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Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria

21 January 2018

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Endonucleolytic function of MutLalpha in human mismatch repair

21 January 2018

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DNA damage in the nucleosome core is refractory to repair by human excision nuclease

21 January 2018

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The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle

21 January 2018

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Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex

21 January 2018

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Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site

21 January 2018

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Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein

21 January 2018

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The chemical toxicology of 2-deoxyribose oxidation in DNA.

21 January 2018

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Alpha-anomeric deoxynucleotides, anoxic products of ionizing radiation, are substrates for the endonuclease IV-type AP endonucleases

21 January 2018

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Keynote: past, present, and future aspects of base excision repair

21 January 2018

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An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases

21 January 2018

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Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA

21 January 2018

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The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast

21 January 2018

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Structural characterization of the Fpg family of DNA glycosylases

21 January 2018

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Structure and function in the uracil-DNA glycosylase superfamily

21 January 2018

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Uracil in DNA and its processing by different DNA glycosylases

21 January 2018

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Recognition and removal of oxidized guanines in duplex DNA by the base excision repair enzymes hOGG1, yOGG1, and yOGG2.

21 January 2018

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Chromatin and DNA repair: the benefits of relaxation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.20226

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26 August 2017

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