Anti-oncogenic potential of the eIF4E-binding proteins (Q38003091)

26 August 2017

title

Anti-oncogenic potential of the eIF4E-binding proteins (English)

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26 August 2017

Y Martineau

1

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26 August 2017

R Azar

series ordinal

2

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26 August 2017

C Bousquet

series ordinal

3

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26 August 2017

S Pyronnet

series ordinal

4

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26 August 2017

language of work or name

English

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publication date

16 April 2012

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26 August 2017

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26 August 2017

volume

32

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26 August 2017

issue

6

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26 August 2017

page(s)

671-677

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Characterization of mammalian eIF4E-family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

A Novel Functional Human Eukaryotic Translation Initiation Factor 4G

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Selective modification of eukaryotic initiation factor 4F (eIF4F) at the onset of cell differentiation: recruitment of eIF4GII and long-lasting phosphorylation of eIF4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Ras mediates translation initiation factor 4E-induced malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Phosphorylation of Eukaryotic Translation Initiation Factor 4G1 (eIF4G1) by Protein Kinase Cα Regulates eIF4G1 Binding to Mnk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Regulation of cap-dependent translation by eIF4E inhibitory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Localisation and regulation of the eIF4E-binding protein 4E-BP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

A variant mimicking hyperphosphorylated 4E-BP inhibits protein synthesis in a sea urchin cell-free, cap-dependent translation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Cell-cycle-dependent translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Pim family kinases enhance tumor growth of prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

For better or for worse: the role of Pim oncogenes in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

4E-BP functions as a metabolic brake used under stress conditions but not during normal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

eIF4E/4E-BP dissociation and 4E-BP degradation in the first mitotic division of the sea urchin embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Hypoxia and DNA-damaging agent bleomycin both increase the cellular level of the protein 4E-BP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Activation of p53 stimulates proteasome-dependent truncation of eIF4E-binding protein 1 (4E-BP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Regulation of protein synthesis by ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

p53-dependent translational control of senescence and transformation via 4E-BPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The biological and therapeutic relevance of mRNA translation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

eIF4E Association with 4E-BP Decreases Rapidly Following Fertilization in Sea Urchin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.116

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.116

1 reference

Dimensions Publication ID

26 August 2017

1049237708

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1 reference