Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics (Q38002488)

26 August 2017

title

Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics (English)

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26 August 2017

Takaharu Okada

1

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26 August 2017

Saya Moriyama

series ordinal

2

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26 August 2017

Masahiro Kitano

series ordinal

3

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26 August 2017

publication date

1 May 2012

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26 August 2017

published in

Immunological Reviews

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26 August 2017

volume

247

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26 August 2017

issue

1

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26 August 2017

page(s)

120-132

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Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

26 August 2017

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Bcl6 mediates the development of T follicular helper cells

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The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

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B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

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Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

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In vivo regulation of Bcl6 and T follicular helper cell development

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ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

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Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone

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Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

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Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

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Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells

21 January 2018

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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

21 January 2018

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Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses

21 January 2018

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The dynamic structure of the germinal center.

21 January 2018

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CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers

21 January 2018

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Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles

21 January 2018

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The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Conduits mediate transport of low-molecular-weight antigen to lymph node follicles

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

B cell follicles and antigen encounters of the third kind

21 January 2018

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EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues

21 January 2018

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Oxysterols direct immune cell migration via EBI2

21 January 2018

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Oxysterols direct B-cell migration through EBI2

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Visualizing B cell capture of cognate antigen from follicular dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

21 January 2018

1 reference

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Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells

21 January 2018

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Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

21 January 2018

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Signatures of the immune response

21 January 2018

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The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement

21 January 2018

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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

21 January 2018

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Imaging of germinal center selection events during affinity maturation

21 January 2018

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Germinal centres: role in B-cell physiology and malignancy

21 January 2018

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Germinal centers without T cells

21 January 2018

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Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers

21 January 2018

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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor.

21 January 2018

1 reference

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In vivo control of B-cell survival and antigen-specific B-cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Affinity of antigen encounter and other early B-cell signals determine B-cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Toll-like receptors and innate immunity in B-cell activation and antibody responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Immunostimulatory activity of haptenated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Toll-like Receptor 7 Controls the Anti-Retroviral Germinal Center Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Programming the magnitude and persistence of antibody responses with innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

IFN regulatory factor 8 regulates MDM2 in germinal center B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Short-circuiting long-lived humoral immunity by the heightened engagement of CD40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Cytokine-secreting follicular T cells shape the antibody repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

SAP-controlled T-B cell interactions underlie germinal centre formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

SAP is required for generating long-term humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Regulation and functions of Blimp-1 in T and B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Human blood CXCR5( )CD4( ) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

BCL6 is critical for the development of a diverse primary B cell repertoire

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01120.X

STAT5 is a potent negative regulator of TFH cell differentiation

21 January 2018

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10.1111/J.1600-065X.2012.01120.X

21 January 2018

Identifiers

DOI

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release_5kowg5n7ane2dnvktt27s4tlzy

26 August 2017

Fatcat ID

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https://api.fatcat.wiki/v0/release/5kowg5n7ane2dnvktt27s4tlzy

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