NF-κB and the link between inflammation and cancer (Q37995696)

26 August 2017

title

NF-κB and the link between inflammation and cancer (English)

1 reference

26 August 2017

0 references

0 references

3

Michael Karin

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26 August 2017

Joseph A DiDonato

1

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26 August 2017

Frank Mercurio

series ordinal

2

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26 August 2017

language of work or name

1 reference

1 March 2012

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26 August 2017

published in

Immunological Reviews

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26 August 2017

volume

246

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26 August 2017

issue

1

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26 August 2017

page(s)

379-400

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DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide

26 August 2017

cites work

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Immunity, Inflammation, and Cancer

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Inflammation meets cancer, with NF-κB as the matchmaker

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

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Cancer-related inflammation

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NF-kappaB as a critical link between inflammation and cancer

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Integrative genomic approaches identify IKBKE as a breast cancer oncogene

21 January 2018

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Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

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Initial genome sequencing and analysis of multiple myeloma

21 January 2018

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

21 January 2018

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

21 January 2018

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Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

21 January 2018

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I kappa B: a specific inhibitor of the NF-kappa B transcription factor

21 January 2018

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Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

21 January 2018

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The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

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Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

21 January 2018

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Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters

21 January 2018

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The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes

21 January 2018

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Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The precursor of NF-kappa B p50 has I kappa B-like functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

It takes two to tango: IκBs, the multifunctional partners of NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Regulation of NF-κB by ubiquitination and degradation of the IκBs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Identification and characterization of an IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IKK1-deficient mice exhibit abnormal development of skin and skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Non-canonical NF-κB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The Rel/NF-kappaB signal transduction pathway: introduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Rel/NF-kappaB transcription factors: key mediators of B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IkappaB kinase signaling is essential for maintenance of mature B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Regulation and function of IKK and IKK-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Signaling to NF-kappaB: regulation by ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

A loss-of-function RNA interference screen for molecular targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Oncogenically active MYD88 mutations in human lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Oncogenic activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Regulation and function of NF-kappaB transcription factors in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Linking inflammation reactions to cancer: novel targets for therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Molecular pathways and targets in cancer-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Promotion of colorectal neoplasia in experimental murine ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NF-kappaB in cancer: a marked target

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Prostate cancer in a transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Tumor suppressive maspin and epithelial homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated I kappa B-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Integrating cell-signalling pathways with NF-kappaB and IKK function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

p53 and NF-kappaB crosstalk: IKKalpha tips the balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The IkappaB kinase - a bridge between inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The noncanonical NF-κB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The NF-kappaB-independent functions of IKK subunits in immunity and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

A new fork for clinical application: targeting forkhead transcription factors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NEMO-binding domain peptide inhibits constitutive NF-κB activity and reduces tumor burden in a canine model of relapsed, refractory diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Proteasome inhibition: a novel approach to cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Novel proteasome inhibitors to overcome bortezomib resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Protein degradation or regulation: Ub the judge

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Elevated expression of Wnt antagonists is a common event in hepatoblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Associations Among -TrCP, an E3 Ubiquitin Ligase Receptor, -Catenin, and NF- B in Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Molecular Pathways Linking Inflammation and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

NF-kappaB: a key role in inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The resolution of inflammation: anti-inflammatory roles for NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

The distribution of secondary growths in cancer of the breast. 1889

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Crystal structure of inhibitor of κB kinase β

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1600-065X.2012.01099.X

10.1111/J.1600-065X.2012.01099.X

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference