Cinacalcet: will it play a role in reducing cardiovascular events? (Q37993874)

26 August 2017

title

Cinacalcet: will it play a role in reducing cardiovascular events? (English)

1 reference

26 August 2017

Cristina Karohl

1

1 reference

26 August 2017

Paolo Raggi

series ordinal

2

1 reference

26 August 2017

publication date

15 March 2012

1 reference

26 August 2017

1 reference

26 August 2017

volume

8

1 reference

26 August 2017

issue

3

1 reference

26 August 2017

page(s)

357-370

1 reference

Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma

26 August 2017

cites work

1 reference

Cinacalcet HCl Reduces Hypercalcemia in Primary Hyperparathyroidism across a Wide Spectrum of Disease Severity

21 January 2018

1 reference

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

21 January 2018

1 reference

Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

21 January 2018

1 reference

Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo

21 January 2018

1 reference

Reciprocal Control of 1,25-Dihydroxyvitamin D and FGF23 Formation Involving the FGF23/Klotho System

21 January 2018

1 reference

Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options.

21 January 2018

1 reference

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

21 January 2018

1 reference

Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans

21 January 2018

1 reference

Decreased expression of calcium receptor in parathyroid tissue in patients with hyperparathyroidism secondary to chronic renal failure

21 January 2018

1 reference

Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients.

21 January 2018

1 reference

FGF23 fails to inhibit uremic parathyroid glands

21 January 2018

1 reference

Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease

21 January 2018

1 reference

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.

21 January 2018

1 reference

Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism

21 January 2018

1 reference

Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure.

21 January 2018

1 reference

Parathyroid hormone, a uremic toxin

21 January 2018

1 reference

Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS).

21 January 2018

1 reference

Clinical subtypes of Alzheimer's disease

21 January 2018

1 reference

Serum iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population

21 January 2018

1 reference

Mineral metabolism, mortality, and morbidity in maintenance hemodialysis

21 January 2018

1 reference

Consistent control of mineral and bone disorder in incident hemodialysis patients

21 January 2018

1 reference

Are PTH serum levels predictive of coronary calcifications in haemodialysis patients?

21 January 2018

1 reference

Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl.

21 January 2018

1 reference

The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease.

21 January 2018

1 reference

The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats.

21 January 2018

1 reference

The calcimimetic AMG 641 accelerates regression of extraosseous calcification in uremic rats.

21 January 2018

1 reference

R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).

21 January 2018

1 reference

Cinacalcet suppresses calcification of the aorta and heart in uremic rats

21 January 2018

1 reference

Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol.

21 January 2018

1 reference

Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues

21 January 2018

1 reference

Calcium receptor is functionally expressed in rat neonatal ventricular cardiomyocytes

21 January 2018

1 reference

Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.

21 January 2018

1 reference

Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells

21 January 2018

1 reference

Extracellular calcium sensing in rat aortic vascular smooth muscle cells

21 January 2018

1 reference

Cloning and characterization of an extracellular Ca(2 )-sensing receptor from bovine parathyroid

21 January 2018

1 reference

Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs

21 January 2018

1 reference

Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor

21 January 2018

1 reference

Molecular Cloning of a Putative Ca2 -Sensing Receptor cDNA from Human Kidney

21 January 2018

1 reference

Calcium-sensing receptor in the brain.

21 January 2018

1 reference

Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene

21 January 2018

1 reference

Expression of an extracellular calcium-sensing receptor in rat stomach

21 January 2018

1 reference

Extracellular calcium sensing receptor in human pancreatic cells

21 January 2018

1 reference

Identification and localization of the extracellular calcium-sensing receptor in human breast

21 January 2018

1 reference

Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa

21 January 2018

1 reference

Functional proteins involved in regulation of intracellular Ca(2 ) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics

21 January 2018

1 reference

Physiology and pathophysiology of the calcium-sensing receptor in the kidney

21 January 2018

1 reference

A region in the seven-transmembrane domain of the human Ca2 receptor critical for response to Ca2 .

21 January 2018

1 reference

Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2 receptor

21 January 2018

1 reference

Aminoglycosides increase intracellular calcium levels and ERK activity in proximal tubular OK cells expressing the extracellular calcium-sensing receptor

21 January 2018

1 reference

Calcium acts as a first messenger through the calcium-sensing receptor in the cardiovascular system

21 January 2018

1 reference

Calcimimetics with potent and selective activity on the parathyroid calcium receptor

21 January 2018

1 reference

L-amino acids regulate parathyroid hormone secretion

21 January 2018

1 reference

The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor

21 January 2018

1 reference

Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl

21 January 2018

1 reference

Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention

21 January 2018

1 reference

The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism

21 January 2018

1 reference

Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis

21 January 2018

1 reference

The calcimimetic agent KRN 1493 lowers plasma parathyroid hormone and ionized calcium concentrations in patients with chronic renal failure on haemodialysis both on the day of haemodialysis and on the day without haemodialysis

21 January 2018

1 reference

The effect of calcitriol, paricalcitol, and a calcimimetic on extraosseous calcifications in uremic rats

21 January 2018

1 reference

The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice.

21 January 2018

1 reference

1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism

21 January 2018

1 reference

Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats

21 January 2018

1 reference

Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats

21 January 2018

1 reference

Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors

21 January 2018

1 reference

Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats.

21 January 2018

1 reference

Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease

21 January 2018

1 reference

A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients.

21 January 2018

1 reference

Impact of high coronary artery calcification score (CACS) on survival in patients on chronic hemodialysis.

21 January 2018

1 reference

Impact of cardiovascular calcification in nondialyzed patients after 24 months of follow-up

21 January 2018

1 reference

Assessment and significance of abdominal aortic calcification in chronic kidney disease

21 January 2018

1 reference

Prevalence and prognostic significance of renal artery calcification in patients with diabetes and proteinuria

21 January 2018

1 reference

Vascular calcification mechanisms

21 January 2018

1 reference

Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification.

21 January 2018

1 reference

Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats

21 January 2018

1 reference

Phosphate regulation of vascular smooth muscle cell calcification

21 January 2018

1 reference

Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism.

21 January 2018

1 reference

Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.

21 January 2018

1 reference

Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels.

21 January 2018

1 reference

Vascular calcification: the killer of patients with chronic kidney disease

21 January 2018

1 reference

Mechanisms of vascular calcification in chronic kidney disease

21 January 2018

1 reference

Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.

21 January 2018

1 reference

Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization.

21 January 2018

1 reference

Vascular calcification in animal models of CKD: A review

21 January 2018

1 reference

Experimental models of renal disease and the cardiovascular system.

21 January 2018

1 reference

Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro

21 January 2018

1 reference

Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification

21 January 2018

1 reference

Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells

21 January 2018

1 reference

Expression of a functional extracellular calcium-sensing receptor in human aortic endothelial cells

21 January 2018

1 reference

Extracellular calcium (Ca2 o)-sensing receptor in a mouse monocyte-macrophage cell line (J774): potential mediator of the actions of Ca2 o on the function of J774 cells

21 January 2018

1 reference

Expression of extracellular calcium (Ca2 o)-sensing receptor in human peripheral blood monocytes

21 January 2018

1 reference

Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism

21 January 2018

1 reference

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

21 January 2018

1 reference

Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall

21 January 2018

1 reference

Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor

21 January 2018

1 reference

Left ventricular mass in chronic kidney disease and ESRD.

21 January 2018

1 reference

Effect of parathyroid hormone on rat heart cells

21 January 2018

1 reference

Parathyroid hormone improves contractile performance of adult rat ventricular cardiomyocytes at low concentrations in a non-acute way.

21 January 2018

1 reference

Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic.

21 January 2018

1 reference

Expression and function of the calcium-sensing receptor in juxtaglomerular cells

21 January 2018

1 reference

Calcium-sensing receptors modulate renin release in vivo and in vitro in the rat.

21 January 2018

1 reference

Acute activation of the calcium-sensing receptor inhibits plasma renin activity in vivo

21 January 2018

1 reference

Interleukin-6 production and secretion by human parathyroids

21 January 2018

1 reference

Regulation of parathyroid hypertensive factor secretion by Ca2 in spontaneously hypertensive rat parathyroid cells

21 January 2018

1 reference

Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

21 January 2018

1 reference

Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet

21 January 2018

1 reference

Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats

21 January 2018

1 reference

Cinacalcet and achievement of the NKF/K-DOQI recommended target values for bone and mineral metabolism in real-world clinical practice--the ECHO observational study

21 January 2018

1 reference

The OPTIMA study: assessing a new cinacalcet (Sensipar/Mimpara) treatment algorithm for secondary hyperparathyroidism

21 January 2018

1 reference

Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism

21 January 2018

1 reference

Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism

21 January 2018

1 reference

Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients.

21 January 2018

1 reference

Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE): rationale and design overview

21 January 2018

1 reference

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease

21 January 2018

1 reference

Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis

21 January 2018

1 reference

High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients.

21 January 2018

1 reference

Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality

21 January 2018

1 reference

Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease

21 January 2018

1 reference

Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD.

21 January 2018

1 reference

Cinacalcet effectively reduces parathyroid hormone secretion and gland volume regardless of pretreatment gland size in patients with secondary hyperparathyroidism

21 January 2018

1 reference

Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FCA.11.82

1 reference

26 August 2017

1 reference