Epithelial stem cells, wound healing and cancer (Q37987841)

26 August 2017

title

Epithelial stem cells, wound healing and cancer (English)

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26 August 2017

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3

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26 August 2017

Esther N Arwert

1

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Esther Hoste

object named as

Esther Hoste

series ordinal

2

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language of work or name

English

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publication date

24 February 2012

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26 August 2017

published in

Nature Reviews Cancer

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26 August 2017

volume

12

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26 August 2017

issue

3

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26 August 2017

page(s)

170-180

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The therapeutic potential of stem cells

26 August 2017

cites work

1 reference

Chronic inflammation, the tumor microenvironment and carcinogenesis

31 March 2020

1 reference

Pathophysiology of hepatitis C virus infection and related liver disease

31 March 2020

1 reference

Molecular pathogenesis of human hepatocellular carcinoma.

31 March 2020

1 reference

Helicobacter Pylori and Inflammation

31 March 2020

1 reference

Wound healing after trauma may predispose to lung cancer metastasis: review of potential mechanisms

31 March 2020

1 reference

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

31 March 2020

1 reference

Hallmarks of Cancer: The Next Generation

31 March 2020

1 reference

31 March 2020

Wound repair at a glance

1 reference

Cancer as an overhealing wound: an old hypothesis revisited

31 March 2020

1 reference

Type VII collagen is required for Ras-driven human epidermal tumorigenesis

31 March 2020

1 reference

Understanding the pathogenesis of recessive dystrophic epidermolysis bullosa squamous cell carcinoma

31 March 2020

1 reference

Wounding and its role in RSV-mediated tumor formation

31 March 2020

1 reference

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

31 March 2020

1 reference

The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

1 reference

Tumors as organs: complex tissues that interface with the entire organism

31 March 2020

1 reference

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells

31 March 2020

1 reference

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

31 March 2020

1 reference

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

31 March 2020

1 reference

Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis

31 March 2020

1 reference

Involvement of follicular stem cells in forming not only the follicle but also the epidermis

31 March 2020

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Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

31 March 2020

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Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

31 March 2020

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Hair follicle stem cells are specified and function in early skin morphogenesis

31 March 2020

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Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment

31 March 2020

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Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

31 March 2020

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The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

31 March 2020

1 reference

Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells

31 March 2020

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Epidermal stem cells arise from the hair follicle after wounding

31 March 2020

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Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland

31 March 2020

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A single type of progenitor cell maintains normal epidermis.

31 March 2020

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An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution.

31 March 2020

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Lhx2 maintains stem cell character in hair follicles

31 March 2020

1 reference

Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury

31 March 2020

1 reference

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

31 March 2020

1 reference

Hair cycle regulation of Hedgehog signal reception

31 March 2020

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Essential role for Sonic hedgehog during hair follicle morphogenesis

31 March 2020

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Sonic hedgehog signaling is essential for hair development

31 March 2020

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Basal cell carcinomas in mice overexpressing sonic hedgehog

31 March 2020

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Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinomas

31 March 2020

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Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/ mice exposed to radiation

31 March 2020

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Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.

31 March 2020

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Basal cell carcinomas in mice overexpressing Gli2 in skin

31 March 2020

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Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.

31 March 2020

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Identification of the cell lineage at the origin of basal cell carcinoma

31 March 2020

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Wounding mobilizes hair follicle stem cells to form tumors

31 March 2020

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Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1 /− Mice

31 March 2020

1 reference

Polyclonal origin of mouse skin papillomas

31 March 2020

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A common human skin tumour is caused by activating mutations in beta-catenin

31 March 2020

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Human sebaceous tumors harbor inactivating mutations in LEF1.

31 March 2020

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Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

31 March 2020

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Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type

31 March 2020

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Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

31 March 2020

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Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation

31 March 2020

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Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing

31 March 2020

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Wnt signaling induces epithelial differentiation during cutaneous wound healing

31 March 2020

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Differential expression and localization of WNTs in an animal model of skin wound healing.

31 March 2020

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beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

31 March 2020

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Contribution of stem cells and differentiated cells to epidermal tumours

31 March 2020

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Identifying the cellular origin of squamous skin tumors

31 March 2020

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Defining the origins of Ras/p53-mediated squamous cell carcinoma

31 March 2020

1 reference

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling

31 March 2020

1 reference

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

31 March 2020

1 reference

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

31 March 2020

1 reference

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

31 March 2020

1 reference

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

31 March 2020

1 reference

C57BL/6 mice are resistant to tumor promotion by full thickness skin wounding

31 March 2020

1 reference

Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

31 March 2020

1 reference

Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis.

31 March 2020

1 reference

Stem-cell hierarchy in skin cancer

31 March 2020

1 reference

New roles for integrins in squamous-cell carcinoma

31 March 2020

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Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions

31 March 2020

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Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

31 March 2020

1 reference

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

31 March 2020

1 reference

High-mobility group box 1 and cancer

31 March 2020

1 reference

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

31 March 2020

1 reference

Canonical notch signaling functions as a commitment switch in the epidermal lineage

31 March 2020

1 reference

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

31 March 2020

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Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

31 March 2020

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Notch1 functions as a tumor suppressor in mouse skin

31 March 2020

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Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

31 March 2020

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Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity

31 March 2020

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Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

31 March 2020

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Mek1 alters epidermal growth and differentiation

31 March 2020

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Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis

31 March 2020

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B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis

31 March 2020

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FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

31 March 2020

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De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

31 March 2020

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c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin

31 March 2020

1 reference

Little evidence for developmental plasticity of adult hematopoietic stem cells

31 March 2020

1 reference

In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions.

31 March 2020

1 reference

Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair

31 March 2020

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Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type

31 March 2020

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Bone marrow cells engraft within the epidermis and proliferatein vivo with no evidence of cell fusion

31 March 2020

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Bone marrow transplantation for recessive dystrophic epidermolysis bullosa

31 March 2020

1 reference

PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia

31 March 2020

1 reference

Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing

31 March 2020

1 reference

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

31 March 2020

1 reference

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia

31 March 2020

1 reference

Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice

31 March 2020

1 reference

EGF and TGF-alpha in wound healing and repair

31 March 2020

1 reference

Autocrine TGFalpha expression in the regulation of initiation of human colon carcinoma growth

31 March 2020

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Wound epithelialization deficits in the transforming growth factor-alpha knockout mouse

31 March 2020

1 reference

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

31 March 2020

1 reference

Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma

31 March 2020

1 reference

Basic fibroblast growth factor stimulation of epidermal wound healing in pigs

31 March 2020

1 reference

Delayed wound healing in immunodeficient TGF-beta 1 knockout mice

31 March 2020

1 reference

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro

31 March 2020

1 reference

TGFbeta signalling: a complex web in cancer progression

31 March 2020

1 reference

TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.

31 March 2020

1 reference

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

31 March 2020

1 reference

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

31 March 2020

1 reference

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

31 March 2020

1 reference

Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing

31 March 2020

1 reference

Research of PDGF-BB gel on the wound healing of diabetic rats and its pharmacodynamics

31 March 2020

1 reference

The role of vascular endothelial growth factor in wound healing

31 March 2020

1 reference

Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

31 March 2020

1 reference

Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice

31 March 2020

1 reference

IL-6 involvement in epithelial cancers

31 March 2020

1 reference

TNF and cancer: the two sides of the coin

31 March 2020

1 reference

Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration

31 March 2020

1 reference

Colony-stimulating factors in inflammation and autoimmunity.

31 March 2020

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Macrophage Colony-Stimulating Factor Accelerates Wound Healing and Upregulates TGF-β1 mRNA Levels through Tissue Macrophages

31 March 2020

1 reference

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

31 March 2020

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Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice

31 March 2020

1 reference

The inflammatory chemokines CCL2 and CCL5 in breast cancer

31 March 2020

1 reference

Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1.

31 March 2020

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CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer

31 March 2020

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Role of melanoma growth stimulatory activity (MGSA/gro) on keratinocyte function in wound healing

31 March 2020

1 reference

CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

31 March 2020

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Bioactive interleukin-8 is expressed in wounds and enhances wound healing

31 March 2020

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Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis

31 March 2020

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Biphasic expression of stromal cell-derived factor-1 during human wound healing

31 March 2020

1 reference

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer

31 March 2020

1 reference

Cancer in man at site of prior benign lesion of skin or mucous membrane: a review

31 March 2020

1 reference

12 December 2020

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion

1 reference

12 December 2020

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization

1 reference

12 December 2020

Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration

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12 December 2020

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

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12 December 2020

Pathways sufficient to induce epidermal carcinogenesis

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12 December 2020

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas

1 reference

12 December 2020

Inflammation, DNA methylation and colitis-associated cancer

1 reference

12 December 2020

Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation.

1 reference

12 December 2020

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

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12 December 2020

Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing

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12 December 2020

Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis.

1 reference

12 December 2020

Anti-angiogenesis therapies: their potential in cancer management

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12 December 2020

Identifiers

DOI

10.1038/NRC3217

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26 August 2017

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