Survivin in solid tumors: rationale for development of inhibitors. (Q37974867)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22234703 AND SRC:MED&resulttype=core&format=json

20 January 2020

title

Survivin in solid tumors: rationale for development of inhibitors (English)

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20 January 2020

1

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20 January 2020

author name string

Denis C Talbot

series ordinal

2

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20 January 2020

publication date

1 April 2012

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20 January 2020

published in

Current Oncology Reports

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20 January 2020

volume

14

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20 January 2020

issue

2

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20 January 2020

page(s)

120-128

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New wirings in the survivin networks

20 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin 2alpha: a novel Survivin splice variant expressed in human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Identification of a novel splice variant of the human anti-apoptopsis gene survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34( ) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin, a cancer target with an emerging role in normal adult tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

The case for survivin as a regulator of microtubule dynamics and cell-death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

The case for Survivin as mitotic regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafarnib) through Akt/mammalian target of rapamycin-mediated increases in survivin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Chromosome alignment and segregation regulated by ubiquitination of survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

A p34(cdc2) survival checkpoint in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Phosphorylation by aurora-B negatively regulates survivin function during mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Regulation of survivin function by Hsp90

21 January 2018

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https://api.crossref.org/works/10.1007/S11912-012-0215-2

Validating survivin as a cancer therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Molecular mechanisms of caspase regulation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin, versatile modulation of cell division and apoptosis in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Chemically synthesized human survivin does not inhibit caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

HBXIP functions as a cofactor of survivin in apoptosis suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Control of apoptosis and mitotic spindle checkpoint by survivin

21 January 2018

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https://api.crossref.org/works/10.1007/S11912-012-0215-2

Cell division and cell survival in the absence of survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin modulates microtubule dynamics and nucleation throughout the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Activated checkpoint kinase 2 provides a survival signal for tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Control of apoptosis during angiogenesis by survivin expression in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

A role for survivin in chemoresistance of endothelial cells mediated by VEGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Analysis of human transcriptomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Quantitatively determined survivin expression levels are of prognostic value in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Aberrant regulation of survivin by the RB/E2F family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Caspase 2-mediated tumor suppression involves survivin gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin mediates resistance to antiandrogen therapy in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer cells contributes to Taxol resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Knockdown of survivin expression by small interfering RNA reduces the clonogenic survival of human sarcoma cell lines independently of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Adenoviral infection of survivin antisense sensitizes prostate cancer cells to etoposide in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Silencing survivin splice variant 2B leads to antitumor activity in taxane--resistant ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Antisense Inhibition of Survivin Expression as a Cancer Therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

SPC3042: a proapoptotic survivin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Phase I/II clinical safety studies of terameprocol vaginal ointment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Rational design of shepherdin, a novel anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S11912-012-0215-2

Survivin does not inhibit caspase-3 activity

21 January 2018

1 reference

12 December 2020

Survivin, cancer networks and pathway-directed drug discovery.

1 reference

12 December 2020

Multicenter phase II trial of YM155, a small-molecule suppressor of survivin, in patients with advanced, refractory, non-small-cell lung cancer

1 reference

12 December 2020

High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma

1 reference

12 December 2020

Anti-apoptosis gene, survivin, and prognosis of neuroblastoma

1 reference

12 December 2020

Phase I and pharmacokinetic study of YM155, a small-molecule inhibitor of survivin.

1 reference

12 December 2020

Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties

1 reference

12 December 2020

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs

1 reference

12 December 2020

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation

1 reference

12 December 2020

Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

1 reference

12 December 2020

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study

1 reference

12 December 2020

Regulation of survivin expression by IGF-1/mTOR signaling

1 reference

12 December 2020

Association of long-term administration of the survivin mRNA-targeted antisense oligonucleotide LY2181308 with reversible kidney injury in a patient with metastatic melanoma

1 reference

12 December 2020

Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients

1 reference

12 December 2020

Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer

1 reference

12 December 2020

Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis

1 reference

12 December 2020

YM155, a selective survivin suppressant, inhibits tumor spread and prolongs survival in a spontaneous metastatic model of human triple negative breast cancer

1 reference

12 December 2020

Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma

1 reference

12 December 2020

Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions

1 reference

12 December 2020

Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas

1 reference

12 December 2020

Expression of survivin and its relationship to loss of apoptosis in breast carcinomas

1 reference

12 December 2020

Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.

1 reference

12 December 2020

The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner

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12 December 2020

Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients

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12 December 2020

10.1007/S11912-012-0215-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22234703 AND SRC:MED&resulttype=core&format=json

20 January 2020

1 reference