Road to Alzheimer’s Disease: The Pathomechanism Underlying (Q37972068)

26 August 2017

title

Road to Alzheimer's disease: the pathomechanism underlying (English)

1 reference

26 August 2017

Road to Alzheimer’s Disease: The Pathomechanism Underlying (English)

1 reference

21 December 2024

0 references

3

Willayat Yousuf Wani

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22205086

21 December 2024

author name string

Alka Kaushal

series ordinal

2

1 reference

26 August 2017

Kiran Dip Gill

series ordinal

4

1 reference

26 August 2017

R. Anand

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22205086

21 December 2024

language of work or name

1 reference

28 December 2011

1 reference

full work available at URL

26 August 2017

https://www.karger.com/Article/Pdf/332218

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22205086

21 December 2024

1 reference

26 August 2017

volume

79

1 reference

26 August 2017

issue

2

1 reference

26 August 2017

page(s)

55-71

1 reference

2008 Alzheimer's disease facts and figures

26 August 2017

cites work

1 reference

Global prevalence of dementia: a Delphi consensus study

21 January 2018

1 reference

Worldwide variation in the doubling time of Alzheimer's disease incidence rates

21 January 2018

1 reference

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

21 January 2018

1 reference

Genetics of Alzheimer disease

21 January 2018

1 reference

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

21 January 2018

1 reference

Causes of oxidative stress in Alzheimer disease.

21 January 2018

1 reference

Oxidative stress signalling in Alzheimer's disease

21 January 2018

1 reference

Alzheimer disease, the two-hit hypothesis: an update

21 January 2018

1 reference

Dysregulation of calcium homeostasis in Alzheimer's disease

21 January 2018

1 reference

Expression of Nrf2 in neurodegenerative diseases

21 January 2018

1 reference

Excitotoxicity and new antiglutamatergic strategies in Parkinson's disease and Alzheimer's disease

21 January 2018

1 reference

Kynurenines, neurodegeneration and Alzheimer's disease

21 January 2018

1 reference

The role of apolipoprotein E in Alzheimer's disease

21 January 2018

1 reference

Microglia and Alzheimer's disease

21 January 2018

1 reference

Cholesterol and statins in Alzheimer's disease: current controversies

21 January 2018

1 reference

Calcium signaling and neurodegenerative diseases

21 January 2018

1 reference

Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model.

21 January 2018

1 reference

Copper, iron and zinc in Alzheimer's disease senile plaques

21 January 2018

1 reference

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

1 reference

Alzheimer's disease: a pathogenic role for aluminosilicate-induced phagocytic free radicals

21 January 2018

1 reference

Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid

21 January 2018

1 reference

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

21 January 2018

1 reference

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

21 January 2018

1 reference

The proteasome in brain aging

21 January 2018

1 reference

The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis

21 January 2018

1 reference

Immortalized hippocampal cells contain functional luteinizing hormone/human chorionic gonadotropin receptors

21 January 2018

1 reference

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

21 January 2018

1 reference

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

21 January 2018

1 reference

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

21 January 2018

1 reference

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease

21 January 2018

1 reference

Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease

21 January 2018

1 reference

Abnormalities of mitochondrial enzymes in Alzheimer disease

21 January 2018

1 reference

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.

21 January 2018

1 reference

Electron transport chain defects in Alzheimer's disease brain

21 January 2018

1 reference

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

21 January 2018

1 reference

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

21 January 2018

1 reference

Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy

21 January 2018

1 reference

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

21 January 2018

1 reference

A suicide note from Alzheimer disease neurons?

21 January 2018

1 reference

Transient adaptation of oxidative stress in mammalian cells.

21 January 2018

1 reference

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

21 January 2018

1 reference

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

1 reference

Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

21 January 2018

1 reference

Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

21 January 2018

1 reference

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

21 January 2018

1 reference

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).

21 January 2018

1 reference

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

21 January 2018

1 reference

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules

21 January 2018

1 reference

JNK activation is associated with intracellular beta-amyloid accumulation

21 January 2018

1 reference

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

21 January 2018

1 reference

Oxidative Stress Signaling in Alzheimers Disease

21 January 2018

1 reference

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

Oxidative stress increases expression and activity of BACE in NT2 neurons

21 January 2018

1 reference

Low free testosterone is an independent risk factor for Alzheimer's disease.

21 January 2018

1 reference

Endogenous estrogen levels and Alzheimer's disease among postmenopausal women.

21 January 2018

1 reference

Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines.

21 January 2018

1 reference

Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men.

21 January 2018

1 reference

An association of elevated serum gonadotropin concentrations and Alzheimer disease?

21 January 2018

1 reference

Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology

21 January 2018

1 reference

Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition

21 January 2018

1 reference

Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal [...]

21 January 2018

1 reference

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

1 reference

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

Oxidative stress in Alzheimer's disease

21 January 2018

1 reference

Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation

21 January 2018

1 reference

Amyloid precursor protein potentiates the neurotrophic activity of NGF

21 January 2018

1 reference

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

21 January 2018

1 reference

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

21 January 2018

1 reference

Neurons may live for decades with neurofibrillary tangles

21 January 2018

1 reference

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

21 January 2018

1 reference

Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?

21 January 2018

1 reference

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

21 January 2018

1 reference

Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?

21 January 2018

1 reference

Serum lipoprotein levels, statin use, and cognitive function in older women

21 January 2018

1 reference

Serum lipids and hippocampal volume: the link to Alzheimer's disease?

21 January 2018

1 reference

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

1 reference

Cholesterol distribution in the Golgi complex of DITNC1 astrocytes is differentially altered by fresh and aged amyloid beta-peptide-(1-42).

21 January 2018

1 reference

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

21 January 2018

1 reference

Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

21 January 2018

1 reference

Staging anti-inflammatory therapy in Alzheimer's disease

21 January 2018

1 reference

APOE genotype-specific differences in the innate immune response

21 January 2018

1 reference

Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function

21 January 2018

1 reference

Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.

21 January 2018

1 reference

GABA(A) receptors in aging and Alzheimer's disease

21 January 2018

1 reference

In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction

21 January 2018

1 reference

21 January 2018

Excitotoxic cell death

1 reference

Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death

21 January 2018

1 reference

Ca2 regulation and gene expression in normal brain aging

21 January 2018

1 reference

Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling

21 January 2018

1 reference

The dysregulation of intracellular calcium in Alzheimer disease

21 January 2018

1 reference

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

21 January 2018

1 reference

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport

21 January 2018

1 reference

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

Autophagy failure in Alzheimer's disease—locating the primary defect

21 January 2018

1 reference

Oxidative stress, accumulation of biological 'garbage', and aging

21 January 2018

1 reference

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

21 January 2018

1 reference

Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease

21 January 2018

1 reference

Mitotic mechanisms in Alzheimer's disease?

21 January 2018

1 reference

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

21 January 2018

1 reference

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis

21 January 2018

1 reference

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

21 January 2018

1 reference

Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease

21 January 2018

1 reference

The amyloid precursor protein: beyond amyloid

21 January 2018

1 reference

Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

21 January 2018

1 reference

Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis.

21 January 2018

1 reference

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

21 January 2018

1 reference

APP processing in Alzheimer's disease

21 January 2018

1 reference

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

1 reference

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

21 January 2018

1 reference

Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).

21 January 2018

1 reference

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

21 January 2018

1 reference

Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease

21 January 2018

1 reference

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

21 January 2018

1 reference

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

21 January 2018

1 reference

Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging

21 January 2018

1 reference

Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

21 January 2018

1 reference

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease

21 January 2018

1 reference

Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus

21 January 2018

1 reference

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia

21 January 2018

1 reference

A synaptic model of memory: long-term potentiation in the hippocampus

21 January 2018

1 reference

Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain

21 January 2018

1 reference

Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain

21 January 2018

1 reference

Alterations in apolipoprotein E expression during aging and neurodegeneration

21 January 2018

1 reference

Effects of age on gene expression during estrogen-induced synaptic sprouting in the female rat.

21 January 2018

1 reference

An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats

21 January 2018

1 reference

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

21 January 2018

1 reference

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

21 January 2018

1 reference

Development of dementing illnesses in an 80-year-old volunteer cohort

21 January 2018

1 reference

Frequent amyloid deposition without significant cognitive impairment among the elderly

21 January 2018

1 reference

What is cognitive reserve? Theory and research application of the reserve concept

21 January 2018

1 reference

Cognitive Reserve and Alzheimer Disease

21 January 2018

1 reference

Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain

21 January 2018

1 reference

Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics

21 January 2018

1 reference

Neuronal hypertrophy in asymptomatic Alzheimer disease

21 January 2018

1 reference

Relationships between biomarkers in aging and dementia

21 January 2018

1 reference

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

21 January 2018

1 reference

Calcium - a life and death signal

21 January 2018

1 reference

Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

21 January 2018

1 reference

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

1 reference

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000332218

1 reference

release_jtunxruwvfbv3pcrrh66ss6arq

26 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jtunxruwvfbv3pcrrh66ss6arq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference