Copper complexes as therapeutic agents (Q37970312)

26 August 2017

title

Copper complexes as therapeutic agents (English)

1 reference

26 August 2017

0 references

2

Anthony R. White

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22187112

21 December 2024

author name string

Clare Duncan

1

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26 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22187112

21 December 2024

publication date

20 December 2011

1 reference

full work available at URL

26 August 2017

http://pubs.rsc.org/en/content/articlepdf/2012/MT/C2MT00174H

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21 December 2024

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26 August 2017

volume

4

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26 August 2017

issue

2

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26 August 2017

page(s)

127-138

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Cellular copper transport and metabolism

26 August 2017

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Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

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The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis

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Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

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Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

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Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

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Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

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Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

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Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

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Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

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Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

21 January 2018

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Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells

21 January 2018

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A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo

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Metal complexes of retinoid derivatives with antiproliferative activity: synthesis, characterization and DNA interaction studies

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Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action

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Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells

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21 January 2018

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Novel complex of copper and a salicylaldehyde pyrazole hydrazone derivative induces apoptosis through up-regulating integrin beta 4 in vascular endothelial cells

21 January 2018

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Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity

21 January 2018

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Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity

21 January 2018

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A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

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Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels

21 January 2018

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Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group

21 January 2018

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Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson's disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).

21 January 2018

1 reference

Neuroprotective effect of acute and chronic administration of copper (II) sulfate against MPP neurotoxicity in mice.

21 January 2018

1 reference

Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP in rats.

21 January 2018

1 reference

Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium

21 January 2018

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Iron and copper metabolism

21 January 2018

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Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.

21 January 2018

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Mechanisms of copper ion mediated Huntington's disease progression

21 January 2018

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Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

21 January 2018

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Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

21 January 2018

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21 January 2018

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21 January 2018

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Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis

21 January 2018

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Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

21 January 2018

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Investigation of a Cu(II)-poly(gamma-glutamic acid) complex in aqueous solution and its insulin-mimetic activity

21 January 2018

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Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM).

21 January 2018

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Serum copper and related variables in rheumatoid arthritis

21 January 2018

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21 January 2018

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21 January 2018

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Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin

21 January 2018

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Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation

21 January 2018

1 reference

Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats

21 January 2018

1 reference

Atherosclerosis — An Inflammatory Disease

21 January 2018

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Measurement of copper-binding sites on low density lipoprotein

21 January 2018

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Increased cholesterol in plasma in a young man during experimental copper depletion

21 January 2018

1 reference

Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis

21 January 2018

1 reference

Improvement of aging-associated cardiovascular dysfunction by the orally administered copper(II)-aspirinate complex

21 January 2018

1 reference

Effects of a single exposure to UVB radiation on the activities and protein levels of copper-zinc and manganese superoxide dismutase in cultured human keratinocytes

21 January 2018

1 reference

Suppressive effect of orally administered copper(II)-aspirinate (Cu2(asp)4) complex on the generation of reactive oxygen species in the skin of animals subjected to UVA exposure

21 January 2018

1 reference

In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese

21 January 2018

1 reference

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2

21 January 2018

1 reference

Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits

21 January 2018

1 reference

Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated α-hydroxycarboxylate ligands

21 January 2018

1 reference

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

21 January 2018

1 reference

Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

21 January 2018

1 reference

Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone

21 January 2018

1 reference

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

21 January 2018

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Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

21 January 2018

1 reference

Preclinical perspectives on platinum resistance

21 January 2018

1 reference

Synthesis and characterization of copper(II) complexes of pyridine-2-carboxamidrazones as potent antimalarial agents

21 January 2018

1 reference

Role of the copper-binding domain in the copper transport function of ATP7B, the P-type ATPase defective in Wilson disease

21 January 2018

8

1 reference

Copper chelation in cancer therapy using tetrathiomolybdate: an evolving paradigm

21 December 2024

27

1 reference

The use of trientine in preventing the effects of interrupting penicillamine therapy in Wilson's disease

21 December 2024

28

1 reference

Chemistry. Metal-based therapeutics

21 December 2024

31

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Heterocyclic thiosemicarbazones: correlation between structure, inhibition of ribonucleotide reductase, and inhibition of DNA viruses

21 December 2024

50

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21 December 2024

53

40

177

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PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 December 2024

74

1 reference

Overcoming cell death and tau phosphorylation mediated by PI3K-inhibition: a cell assay to measure neuroprotection.

21 December 2024

76

1 reference

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

21 December 2024

91

1 reference

The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis

21 December 2024

95

1 reference

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

21 December 2024

97

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Antidiabetic copper(II)-picolinate: impact of the first transition metal in the metallopicolinate complexes

21 December 2024

98

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Copper complexes: a physiological approach to the treatment of ‘inflammatory diseases’

21 December 2024

103

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Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized

21 December 2024

109

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Role of lipoprotein-copper complex in copper catalyzed-peroxidation of low-density lipoprotein

21 December 2024

112

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Dietary copper supplementation reduces atherosclerosis in the cholesterol-fed rabbit

21 December 2024

116

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Copper supplementation of adult men: Effects on blood copper enzyme activities and indicators of cardiovascular disease risk

21 December 2024

118

1 reference

Photoaging and chronological aging profile: Understanding oxidation of the skin

21 December 2024

120

1 reference

Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2

21 December 2024

124

1 reference

The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits

21 December 2024

126

1 reference

Journal of Biological Inorganic Chemistry

21 December 2024

129

page(s)

1

author name string

Portas

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21 December 2024

Identifiers

DOI

10.1039/C2MT00174H

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26 August 2017

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