Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? (Q37969480)

26 August 2017

title

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? (English)

1 reference

26 August 2017

0 references

1 reference

P. M. van der Kraan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22178514

20 December 2024

W. B. van den Berg

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22178514

20 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22178514

20 December 2024

publication date

11 December 2011

1 reference

full work available at URL

26 August 2017

http://www.oarsijournal.com/article/S1063458411003323/pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22178514

https://api.elsevier.com/content/article/PII:S1063458411003323?httpAccept=text/xml

20 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

https://api.elsevier.com/content/article/PII:S1063458411003323?httpAccept=text/plain

20 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Osteoarthritis and Cartilage

20 December 2024

published in

1 reference

26 August 2017

volume

20

1 reference

26 August 2017

issue

3

1 reference

26 August 2017

page(s)

223-232

1 reference

Hypertrophic chondrocytes. The terminal stage of differentiation in the chondrogenic cell lineage?

26 August 2017

cites work

2

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Terminal differentiation of chondrocytes is arrested at distinct stages identified by their expression repertoire of marker genes.

20 December 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Lineage-dependent collagen expression and assembly during osteogenic or chondrogenic differentiation of a mesoblastic cell line

20 December 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

The role of osteochondral progenitor cells in fracture repair.

20 December 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice

20 December 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6.

20 December 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Osteophytes: relevance and biology

20 December 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Collagenase‐3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ. In vitro mimicking effect by transforming growth factor β

20 December 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis

20 December 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage

20 December 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

20 December 2024

12

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages

20 December 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis

20 December 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

NF-kappaB signaling: multiple angles to target OA.

20 December 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

20 December 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy

20 December 2024

17

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders

20 December 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Remodelling of collagen types I, II and X and calcification of human fetal cartilage

20 December 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Identification and characterization of up-regulated genes during chondrocyte hypertrophy

20 December 2024

20

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Different bone growth rates are associated with changes in the expression pattern of types II and X collagens and collagenase 3 in proximal growth plates of the rat tibia

20 December 2024

21

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitro

20 December 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy

20 December 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells

20 December 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.

20 December 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transcriptional regulators of chondrocyte hypertrophy.

20 December 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage

20 December 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis

20 December 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism

20 December 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants

20 December 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Calcification of articular cartilage in human osteoarthritis.

20 December 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

20 December 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence

20 December 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Another look at osteoarthritis

20 December 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Ultrastructure of the deep zone of degenerative osteoarthritic cartilage

20 December 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Autopsy study correlating degree of osteoarthritis, synovitis and evidence of articular calcification

20 December 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

New developments in the pathogenesis of articular cartilage calcification

20 December 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Matrix vesicle enzymes in human osteoarthritis

20 December 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Hypertrophic differentiation and calcification during intervertebral disc degeneration.

20 December 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Degenerative diseases of the vertebral column

20 December 2024

40

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Articular cartilage mineralization in osteoarthritis of the hip.

20 December 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Investigation of calcium crystals in OA knees.

20 December 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis

20 December 2024

43

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage

20 December 2024

44

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Expression of type-X collagen in osteoarthritis

20 December 2024

46

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis

20 December 2024

47

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

20 December 2024

48

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage

20 December 2024

49

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone

20 December 2024

50

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Zonal gene expression of chondrocytes in osteoarthritic cartilage

20 December 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection

20 December 2024

53

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Global analyses of gene expression in early experimental osteoarthritis

20 December 2024

54

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

20 December 2024

55

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Osteoarthritic Lesions. Involvement of three different collagenases

20 December 2024

56

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology

20 December 2024

57

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Osteopontin is expressed by adult human osteoarthritic chondrocytes: protein and mRNA analysis of normal and osteoarthritic cartilage

20 December 2024

58

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Immunohistochemical analysis of ageing and osteoarthritic articular cartilage

20 December 2024

59

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints.

20 December 2024

61

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

20 December 2024

62

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

20 December 2024

63

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway

20 December 2024

64

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Morphological and biochemical evidence for apoptosis in the terminal hypertrophic chondrocytes of the growth plate

20 December 2024

65

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology

20 December 2024

66

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Expression of caspase-3 and -9 relevant to cartilage destruction and chondrocyte apoptosis in human osteoarthritic cartilage

20 December 2024

67

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3.

20 December 2024

68

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis

20 December 2024

70

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Chondrocytes embedded in the epiphyseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis

20 December 2024

71

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model

20 December 2024

72

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Downregulation of Protein Kinase CK2 Activity Facilitates Tumor Necrosis Factor-α-Mediated Chondrocyte Death through Apoptosis and Autophagy

20 December 2024

73

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

20 December 2024

74

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression

20 December 2024

75

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Articular chondrocyte apoptosis in equine osteoarthritis

20 December 2024

76

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Osteoarthritis development in novel experimental mouse models induced by knee joint instability

20 December 2024

77

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

20 December 2024

78

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

20 December 2024

79

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Recent advances in animal models for evaluating chondroprotective drugs

20 December 2024

80

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model

20 December 2024

81

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene

20 December 2024

82

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

20 December 2024

83

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development

20 December 2024

84

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.

20 December 2024

85

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice

20 December 2024

86

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes

20 December 2024

87

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.

20 December 2024

88

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation

20 December 2024

89

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes

20 December 2024

90

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction

20 December 2024

91

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.

20 December 2024

92

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation

20 December 2024

93

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Activation of beta-catenin-LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification.

20 December 2024

94

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner

20 December 2024

95

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation

20 December 2024

96

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Signaling cross-talk between TGF-beta/BMP and other pathways

20 December 2024

97

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

20 December 2024

98

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin

20 December 2024

99

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

20 December 2024

100

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes

20 December 2024

101

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

20 December 2024

102

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Unique and redundant roles of Smad3 in TGF-beta-mediated regulation of long bone development in organ culture

20 December 2024

103

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification

20 December 2024

104

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

20 December 2024

105

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination

20 December 2024

106

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner

20 December 2024

107

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes

20 December 2024

108

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products.

20 December 2024

109

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes

20 December 2024

110

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli

20 December 2024

111

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.

20 December 2024

112

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation.

20 December 2024

113

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.

20 December 2024

114

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation

20 December 2024

115

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice

20 December 2024

116

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

20 December 2024

117

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation

20 December 2024

118

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Intact Pericellular Matrix of Articular Cartilage Is Required for Unactivated Discoidin Domain Receptor 2 in the Mouse Model

20 December 2024

119

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration

20 December 2024

120

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Novel and recurrent mutations clustered in the von Willebrand factor A domain of MATN3 in multiple epiphyseal dysplasia

20 December 2024

121

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis

20 December 2024

122

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

20 December 2024

123

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

20 December 2024

124

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway.

20 December 2024

126

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis

20 December 2024

127

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Mechanics of chondrocyte hypertrophy

20 December 2024

128

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Understanding aging: revealing order out of chaos

20 December 2024

129

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Theory about aging in humans and hypotheses about its possible delay

20 December 2024

130

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence

20 December 2024

131

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Applications of chaos theory to the molecular biology of aging

20 December 2024

132

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1

20 December 2024

133

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling

20 December 2024

134

1 reference

https://api.crossref.org/works/10.1016/J.JOCA.2011.12.003

20 December 2024

Identifiers

1 reference

26 August 2017

1 reference