Druggability Assessment of Protein–Protein Interfaces (Q37958066)

25 August 2017

title

Druggability assessment of protein-protein interfaces (English)

1 reference

25 August 2017

Druggability Assessment of Protein–Protein Interfaces (English)

1 reference

18 December 2024

4

John Roberts

1 reference

25 August 2017

Jutta Wanner

1

1 reference

25 August 2017

Zhengwei Peng

3

1 reference

25 August 2017

David C. Fry

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22098351

18 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22098351

18 December 2024

publication date

1 December 2011

1 reference

25 August 2017

December 2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22098351

full work available at URL

18 December 2024

https://www.tandfonline.com/doi/pdf/10.4155/fmc.11.156

1 reference

Future Medicinal Chemistry

18 December 2024

published in

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25 August 2017

volume

3

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25 August 2017

issue

16

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25 August 2017

page(s)

2021-2038

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High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

25 August 2017

cites work

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Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

21 January 2018

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A hot spot of binding energy in a hormone-receptor interface

21 January 2018

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Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking

21 January 2018

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Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

21 January 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

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Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

21 January 2018

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MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53.

21 January 2018

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

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Targeting IAPs as An Approach to Anti-Cancer Therapy

21 January 2018

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Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.

21 January 2018

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21 January 2018

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

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A specific mechanism of nonspecific inhibition

21 January 2018

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Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction

21 January 2018

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Small-molecule inhibition of TNF-alpha

21 January 2018

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Predicting druggable binding sites at the protein-protein interface.

21 January 2018

1 reference

Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery

21 January 2018

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A survey of available tools and web servers for analysis of protein-protein interactions and interfaces

21 January 2018

1 reference

A structural biology view of target drugability.

21 January 2018

1 reference

Methods for the prediction of protein-ligand binding sites for structure-based drug design and virtual ligand screening

21 January 2018

1 reference

Targeting protein-protein interactions for cancer therapy

21 January 2018

1 reference

Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites

21 January 2018

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Predicting protein interaction sites: binding hot-spots in protein-protein and protein-ligand interfaces

21 January 2018

1 reference

Fpocket: an open source platform for ligand pocket detection.

21 January 2018

1 reference

fpocket: online tools for protein ensemble pocket detection and tracking.

21 January 2018

1 reference

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database

21 January 2018

1 reference

21 January 2018

1 reference

Potent small-molecule binding to a dynamic hot spot on IL-2

21 January 2018

1 reference

Binding of small molecules to an adaptive protein-protein interface

21 January 2018

1 reference

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

21 January 2018

1 reference

Identification and characterization of the first small molecule inhibitor of MDMX

21 January 2018

1 reference

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

21 January 2018

1 reference

Identification of small-molecule inhibitors of the JIP-JNK interaction

21 January 2018

1 reference

Druggability indices for protein targets derived from NMR-based screening data

21 January 2018

1 reference

Fragment screening to predict druggability (ligandability) and lead discovery success.

21 January 2018

1 reference

Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL

21 January 2018

1 reference

Solid-phase syntheses of beta-turn analogues to mimic or disrupt protein-protein interactions.

21 January 2018

1 reference

Design of beta-turn based therapeutic agents

21 January 2018

1 reference

The beta-D-glucose scaffold as a beta-turn mimetic

21 January 2018

1 reference

Scaffolds for blocking protein-protein interactions

21 January 2018

1 reference

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

1 reference

ISIS: interaction sites identified from sequence.

21 January 2018

1 reference

ProMate: a structure based prediction program to identify the location of protein-protein binding sites

21 January 2018

1 reference

Optimal docking area: a new method for predicting protein-protein interaction sites

21 January 2018

1 reference

Utilizing peptide structures as keys for unlocking challenging targets

21 January 2018

1 reference

On the biomedical promise of cell penetrating peptides: limits versus prospects

21 January 2018

1 reference

Cell-penetrating peptides for drug delivery across membrane barriers

21 January 2018

1 reference

Cell-penetrating peptides: from molecular mechanisms to therapeutics.

21 January 2018

1 reference

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

21 January 2018

1 reference

Cell penetrating peptides: overview and applications to the delivery of oligonucleotides

21 January 2018

1 reference

Cell-Penetrating Peptides for Antiviral Drug Development

21 January 2018

1 reference

Synthesis of chemically modified bioactive peptides: recent advances, challenges and developments for medicinal chemistry.

21 January 2018

1 reference

Carrier mediated protein and peptide stabilization

21 January 2018

1 reference

A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

21 January 2018

1 reference

Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains

21 January 2018

1 reference

Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

21 January 2018

1 reference

High Specificity in Protein Recognition by Hydrogen‐Bond‐Surrogate α‐Helices: Selective Inhibition of the p53/MDM2 Complex

21 January 2018

1 reference

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix

21 January 2018

1 reference

The synthesis and study of side-chain lactam-bridged peptides

21 January 2018

1 reference

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

21 January 2018

1 reference

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

A stapled BID BH3 helix directly binds and activates BAX

21 January 2018

1 reference

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

21 January 2018

1 reference

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

Targeting protein-protein interactions: lessons from p53/MDM2.

21 January 2018

1 reference

Foldamers with heterogeneous backbones

21 January 2018

1 reference

beta-Peptides: from structure to function

21 January 2018

1 reference

A field guide to foldamers

21 January 2018

1 reference

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

21 January 2018

1 reference

Synthesis of pyridazine-based scaffolds as alpha-helix mimetics

21 January 2018

1 reference

Heterocyclic alpha-helix mimetics for targeting protein-protein interactions

21 January 2018

1 reference

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

21 January 2018

1 reference

Synthetic non-peptide mimetics of alpha-helices

21 January 2018

1 reference

Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

1 reference

Synthetic mimetics of protein secondary structure domains

21 January 2018

1 reference

Ras/Rap effector specificity determined by charge reversal

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations.

21 January 2018

1 reference

Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods

21 January 2018

1 reference

Prediction of protein-protein interaction inhibitors by chemoinformatics and machine learning methods.

21 January 2018

1 reference

Estimating the size of the human interactome

21 January 2018

1 reference

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

21 January 2018

1 reference

POCKET: a computer graphics method for identifying and displaying protein cavities and their surrounding amino acids

21 January 2018

1 reference

SURFNET: a program for visualizing molecular surfaces, cavities, and intermolecular interactions

21 January 2018

1 reference

The automatic search for ligand binding sites in proteins of known three-dimensional structure using only geometric criteria.

21 January 2018

1 reference

LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins

21 January 2018

1 reference

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation

21 January 2018

1 reference

Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design

21 January 2018

1 reference

Fast prediction and visualization of protein binding pockets with PASS.

21 January 2018

1 reference

Computational mapping identifies the binding sites of organic solvents on proteins

21 January 2018

1 reference

Improved mapping of protein binding sites

21 January 2018

1 reference

PocketPicker: analysis of ligand binding-sites with shape descriptors.

21 January 2018

1 reference

Form follows function: shape analysis of protein cavities for receptor-based drug design

21 January 2018

1 reference

Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

1 reference

BALL--rapid software prototyping in computational molecular biology

21 January 2018

1 reference

Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques

21 January 2018

1 reference

Identifying and characterizing binding sites and assessing druggability

21 January 2018

1 reference

ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery

21 January 2018

1 reference

DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein-protein interactions

21 January 2018

1 reference

Identification of hot spots within druggable binding regions by computational solvent mapping of proteins

21 January 2018

1 reference

Hydrocarbon-Stapled Helices: A Novel Approach for Blocking Protein-Protein Interactions

21 January 2018

1 reference

Transient Pockets on Protein Surfaces Involved in Protein−Protein Interaction

21 January 2018

1 reference

Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors

21 January 2018

18

1 reference

Computational approaches to identifying and characterizing protein binding sites for ligand design

18 December 2024

24

1 reference

ProtorP: a protein-protein interaction analysis server

18 December 2024

37

1 reference

Current trends in the clinical development of peptide therapeutics.

18 December 2024

61

1 reference

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains

18 December 2024

75

1 reference

Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices

18 December 2024

79

1 reference

Synthesis, biological activity and conformational analysis of cyclic GRF analogs

18 December 2024

84

1 reference

Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41

18 December 2024

87

1 reference

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

18 December 2024

90

1 reference

Synthesis and structure of 1,4-dipiperazino benzenes: chiral terphenyl-type peptide helix mimetics

18 December 2024

100

1 reference

Synthesis of alpha-helix mimetics with four side-chains

18 December 2024

101

1 reference

Binding-site assessment by virtual fragment screening

18 December 2024

133

1 reference

18 December 2024

Identifiers

DOI

10.4155/FMC.11.156

1 reference

25 August 2017

1 reference