Role of isocitrate dehydrogenase in glioma. (Q37939994)

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13 February 2020

review article

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title

Role of isocitrate dehydrogenase in glioma (English)

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2

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13 February 2020

author name string

Brian M Alexander

series ordinal

1

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13 February 2020

publication date

1 October 2011

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

13 February 2020

published in

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13 February 2020

volume

11

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13 February 2020

issue

10

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13 February 2020

page(s)

1399-1409

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An integrated genomic analysis of human glioblastoma multiforme

13 February 2020

cites work

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Analysis of the IDH1 codon 132 mutation in brain tumors

21 January 2018

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The prognostic IDH1( R132 ) mutation is associated with reduced NADP -dependent IDH activity in glioblastoma

21 January 2018

1 reference

DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma

21 January 2018

1 reference

Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology.

21 January 2018

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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

21 January 2018

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Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues

21 January 2018

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IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

21 January 2018

1 reference

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

21 January 2018

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Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

21 January 2018

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IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas

21 January 2018

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Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

21 January 2018

1 reference

Analysis of IDH1 and IDH2 mutations in Japanese glioma patients

21 January 2018

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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

21 January 2018

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NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide

21 January 2018

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IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma

21 January 2018

1 reference

Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

21 January 2018

1 reference

Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas

21 January 2018

1 reference

Inactivation of mitochondrial NADP -dependent isocitrate dehydrogenase by hypochlorous acid

21 January 2018

1 reference

Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?

21 January 2018

1 reference

Cytosolic NADP -dependent isocitrate dehydrogenase plays a key role in lipid metabolism

21 January 2018

1 reference

IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells

21 January 2018

1 reference

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

21 January 2018

1 reference

Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP -dependent isocitrate dehydrogenase

21 January 2018

1 reference

Role of cytosolic NADP -dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney

21 January 2018

1 reference

Cellular defense against singlet oxygen-induced oxidative damage by cytosolic NADP -dependent isocitrate dehydrogenase

21 January 2018

1 reference

Cytosolic NADP( )-dependent isocitrate dehydrogenase status modulates oxidative damage to cells

21 January 2018

1 reference

Cellular defense against UVB-induced phototoxicity by cytosolic NADP( )-dependent isocitrate dehydrogenase

21 January 2018

1 reference

Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP -dependent isocitrate dehydrogenase.

21 January 2018

1 reference

Upregulation of cytosolic NADP -dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress

21 January 2018

1 reference

Role of NADP -dependent isocitrate dehydrogenase (NADP -ICDH) on cellular defence against oxidative injury by gamma-rays

21 January 2018

1 reference

Expanding chemical biology of 2-oxoglutarate oxygenases

21 January 2018

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

21 January 2018

1 reference

Mechanism of the Prolyl Hydroxylase Reaction. 2. Kinetic Analysis of the Reaction Sequence

21 January 2018

1 reference

Mechanism of the Prolyl Hydroxylase Reaction. 1. Role of Co-substrates

21 January 2018

1 reference

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

21 January 2018

1 reference

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

21 January 2018

1 reference

Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade

21 January 2018

1 reference

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer

21 January 2018

1 reference

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

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IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

21 January 2018

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Mutant IDH1 Confers an in Vivo Growth in a Melanoma Cell Line with BRAF Mutation

21 January 2018

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IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

21 January 2018

1 reference

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

21 January 2018

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All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2.

21 January 2018

1 reference

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

21 January 2018

1 reference

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

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Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome

21 January 2018

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

21 January 2018

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Glioma IDH1 mutation patterns off the beaten track.

21 January 2018

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2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations

21 January 2018

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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D-2-hydroxyglutaric aciduria: further clinical delineation

21 January 2018

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IDH2 mutations in patients with D-2-hydroxyglutaric aciduria

21 January 2018

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L-2-Hydroxyglutaric aciduria: an inborn error of metabolism?

21 January 2018

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L: -2-Hydroxyglutaric aciduria, a disorder of metabolite repair

21 January 2018

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Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

21 January 2018

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NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria

21 January 2018

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Cancer-associated IDH mutations: biomarker and therapeutic opportunities

21 January 2018

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

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Molecular signatures classify astrocytic gliomas by IDH1 mutation status.

21 January 2018

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R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma.

21 January 2018

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The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view

21 January 2018

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Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth

21 January 2018

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

21 January 2018

1 reference

Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia

21 January 2018

1 reference

Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors

21 January 2018

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Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis

21 January 2018

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IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.

21 January 2018

1 reference

Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes.

21 January 2018

1 reference

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

21 January 2018

1 reference

Small interfering RNA-mediated silencing of mitochondrial NADP -dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs

21 January 2018

1 reference

Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model

21 January 2018

1 reference

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

21 January 2018

1 reference

IDH mutations in glioma and acute myeloid leukemia

21 January 2018

1 reference

IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group

21 January 2018

1 reference

Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERN.11.134

1 reference

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13 February 2020

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