An update on computational oral absorption simulation (Q37937047)

25 August 2017

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title

An update on computational oral absorption simulation (English)

1 reference

25 August 2017

Kirstin Thelen

2

1 reference

25 August 2017

Stefan Willmann

3

1 reference

25 August 2017

Jennifer B. Dressman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21939427

13 December 2024

language of work or name

English

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publication date

23 September 2011

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full work available at URL

25 August 2017

http://www.informapharmascience.com/doi/abs/10.1517/17425255.2011.617743

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21939427

http://www.tandfonline.com/doi/pdf/10.1517/17425255.2011.617743

13 December 2024

1 reference

https://api.crossref.org/works/10.1517/17425255.2011.617743

Expert Opinion on Drug Metabolism & Toxicology

13 December 2024

published in

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25 August 2017

volume

7

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25 August 2017

issue

11

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25 August 2017

page(s)

1345-1364

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Absorption potential: estimating the fraction absorbed for orally administered compounds

25 August 2017

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Physiologically based pharmacokinetics of matrine in the rat after oral administration of pure chemical and ACAPHA

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Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling

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Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles

21 January 2018

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An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery.

21 January 2018

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Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.

21 January 2018

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21 January 2018

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In Vitro–In Vivo Correlation for Gliclazide Immediate-Release Tablets Based on Mechanistic Absorption Simulation

21 January 2018

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21 January 2018

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Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation

21 January 2018

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21 January 2018

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Drug absorption modeling as a tool to define the strategy in clinical formulation development

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21 January 2018

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21 January 2018

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Dynamic dissolution testing to establish in vitro/in vivo correlations for montelukast sodium, a poorly soluble drug

21 January 2018

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Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products

21 January 2018

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Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

21 January 2018

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Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

21 January 2018

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Forecasting in vivo oral absorption and food effect of micronized and nanosized aprepitant formulations in humans

21 January 2018

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Analysis of nifedipine absorption from soft gelatin capsules using PBPK modeling and biorelevant dissolution testing.

21 January 2018

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The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation

21 January 2018

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Application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds

21 January 2018

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Physicochemical characterization of five glyburide powders: a BCS based approach to predict oral absorption

21 January 2018

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Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Development and evaluation of a generic physiologically based pharmacokinetic model for children

21 January 2018

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Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.

21 January 2018

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Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment.

21 January 2018

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PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

21 January 2018

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Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model

21 January 2018

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Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model.

21 January 2018

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Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes.

21 January 2018

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Impact of physiologically based pharmacokinetic modeling on benchmark dose calculations for TCDD-induced biochemical responses

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Development of an In Vitro Digestion Model for Estimating the Bioaccessibility of Soil Contaminants

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Physiologically based pharmacokinetics of zearalenone

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Assessment of bisphenol A exposure in Korean pregnant women by physiologically based pharmacokinetic modeling.

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Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

21 January 2018

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Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model

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Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling

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A Physiologically Based Pharmacokinetic Description of the Oral Uptake, Tissue Dosimetry, and Rates of Metabolism of Bromodichloromethane in the Male Rat

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Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches

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A pharmacokinetic model describing pulsatile uptake of orally-administered carbon tetrachloride

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Mixing-tank model for predicting dissolution rate control or oral absorption

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Identifiers

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25 August 2017

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