Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications. (Q37919924)

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11 February 2020

review article

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title

Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications (English)

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11 February 2020

5

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Enrique Juan Sanchez Pozzi

11 February 2020

6

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11 February 2020

author name string

Marcelo G Roma

1

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11 February 2020

Flavia D Toledo

2

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11 February 2020

Andrea C Boaglio

3

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11 February 2020

Cecilia L Basiglio

4

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11 February 2020

language of work or name

English

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publication date

1 December 2011

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11 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21854363 AND SRC:MED&resulttype=core&format=json

11 February 2020

volume

121

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issue

12

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11 February 2020

page(s)

523-544

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Bile-acid-induced cell injury and protection

11 February 2020

cites work

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Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease

21 January 2018

1 reference

Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression

21 January 2018

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Longitudinal profiles of 15 serum bile acids in patients with intrahepatic cholestasis of pregnancy

21 January 2018

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Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

21 January 2018

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High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis

21 January 2018

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Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.

21 January 2018

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Liver disease associated with canalicular transport defects: current and future therapies

21 January 2018

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What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis

21 January 2018

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Bile salts and cholestasis.

21 January 2018

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Ursodeoxycholic acid cytoprotection: dancing with death receptors and survival pathways

21 January 2018

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Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways

21 January 2018

1 reference

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

21 January 2018

1 reference

An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosis

21 January 2018

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Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis

21 January 2018

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Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

21 January 2018

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Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids

21 January 2018

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Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition

21 January 2018

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Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria

21 January 2018

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Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids

21 January 2018

1 reference

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium

21 January 2018

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Bile salt-induced apoptosis involves NADPH oxidase isoform activation

21 January 2018

1 reference

Antioxidant properties of ursodeoxycholic acid.

21 January 2018

1 reference

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice

21 January 2018

1 reference

Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis

21 January 2018

1 reference

Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants

21 January 2018

1 reference

Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.

21 January 2018

1 reference

Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate

21 January 2018

1 reference

Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells

21 January 2018

1 reference

Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy

21 January 2018

1 reference

Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation

21 January 2018

1 reference

Control of mitochondrial apoptosis by the Bcl-2 family

21 January 2018

1 reference

AP-1 as a regulator of cell life and death

21 January 2018

1 reference

The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis

21 January 2018

1 reference

Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1.

21 January 2018

1 reference

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

21 January 2018

1 reference

Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.

21 January 2018

1 reference

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

21 January 2018

1 reference

Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.

21 January 2018

1 reference

Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines

21 January 2018

1 reference

The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes

21 January 2018

1 reference

Effect of S-adenosyl-L-methionine administration on plasma levels of sulphur-containing amino acids in patients with liver cirrhosis

21 January 2018

1 reference

A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis

21 January 2018

1 reference

High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial

21 January 2018

1 reference

Apoptosis and cytokines in non-alcoholic steatohepatitis

21 January 2018

1 reference

The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.

21 January 2018

1 reference

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

21 January 2018

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Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes

21 January 2018

1 reference

Endoplasmic reticulum stress in liver disease

21 January 2018

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Endoplasmic reticulum stress and apoptosis.

21 January 2018

1 reference

21 January 2018

Caspase-12: an overview

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Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation

21 January 2018

1 reference

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis.

21 January 2018

1 reference

Modulation of apoptosis as a target for liver disease

21 January 2018

1 reference

Bile acids for viral hepatitis

21 January 2018

1 reference

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

21 January 2018

1 reference

Endoplasmic reticulum stress and the unfolded protein response

21 January 2018

1 reference

The protective effect of ursodeoxycholic acid in alloxan-induced diabetes

21 January 2018

1 reference

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease.

21 January 2018

1 reference

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

21 January 2018

1 reference

A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation

21 January 2018

1 reference

Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.

21 January 2018

1 reference

Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers.

21 January 2018

1 reference

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches

21 January 2018

1 reference

Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes

21 January 2018

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Functional modulation of the glucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid

21 January 2018

1 reference

Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation

21 January 2018

1 reference

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

21 January 2018

1 reference

Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity

21 January 2018

1 reference

Ursodeoxycholic acid in chronic hepatitis C

21 January 2018

1 reference

Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum gamma-glutamyltranspeptidase levels

21 January 2018

1 reference

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

21 January 2018

1 reference

Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway

21 January 2018

1 reference

Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition

21 January 2018

1 reference

Oncosis represents the main type of cell death in mouse models of cholestasis

21 January 2018

1 reference

Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein

21 January 2018

1 reference

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

1 reference

Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies

21 January 2018

1 reference

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes

21 January 2018

1 reference

Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition

21 January 2018

1 reference

Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids

21 January 2018

1 reference

Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes

21 January 2018

1 reference

Effects of bile salts on the plasma membranes of isolated rat hepatocytes

21 January 2018

1 reference

Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes

21 January 2018

1 reference

Ursodeoxycholate stabilizes phospholipid-rich membranes and mimics the effect of cholesterol: investigations on large unilamellar vesicles

21 January 2018

1 reference

The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid

21 January 2018

1 reference

Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis

21 January 2018

1 reference

Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene

21 January 2018

1 reference

Pathology and pathogenesis of intrahepatic bile duct loss

21 January 2018

1 reference

GUDC inhibits cytochrome c release from human cholangiocyte mitochondria

21 January 2018

1 reference

Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat.

21 January 2018

1 reference

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

21 January 2018

1 reference

Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine

21 January 2018

1 reference

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

21 January 2018

1 reference

Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes

21 January 2018

1 reference

Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1).

21 January 2018

1 reference

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

1 reference

Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis.

21 January 2018

1 reference

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice

21 January 2018

1 reference

Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration

21 January 2018

1 reference

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

21 January 2018

1 reference

No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis

21 January 2018

1 reference

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

21 January 2018

1 reference

Cytokines in primary biliary cirrhosis

21 January 2018

1 reference

Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis.

21 January 2018

1 reference

Vanishing bile duct syndrome: amoxicillin-clavulanic acid associated intra-hepatic cholestasis responsive to ursodeoxycholic acid

21 January 2018

1 reference

Ursodeoxycholic acid for terbinafine-induced toxic hepatitis

21 January 2018

1 reference

Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized double-blind study controlled with placebo

21 January 2018

1 reference

Effect of Ursodeoxycholic Acid on the Expression of the Hepatocellular Bile Acid Transporters (Ntcp and bsep) in Rats With Estrogen-Induced Cholestasis

21 January 2018

1 reference

Expression of the bile salt export pump is maintained after chronic cholestasis in the rat.

21 January 2018

1 reference

Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat.

21 January 2018

1 reference

The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis

21 January 2018

1 reference

Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis.

21 January 2018

1 reference

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

21 January 2018

1 reference

Novel biotransformation and physiological properties of norursodeoxycholic acid in humans.

21 January 2018

1 reference

The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects

21 January 2018

1 reference

Cystic fibrosis-associated liver disease

21 January 2018

1 reference

Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion

21 January 2018

1 reference

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

21 January 2018

1 reference

Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis

21 January 2018

1 reference

Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis

21 January 2018

1 reference

Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat.

21 January 2018

1 reference

Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases.

21 January 2018

1 reference

Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.

21 January 2018

1 reference

Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats

21 January 2018

1 reference

Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis

21 January 2018

1 reference

Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver

21 January 2018

1 reference

Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase

21 January 2018

1 reference

Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver

21 January 2018

1 reference

Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver

21 January 2018

1 reference

Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver

21 January 2018

1 reference

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.

21 January 2018

1 reference

The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis

21 January 2018

1 reference

Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation

21 January 2018

1 reference

A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection

21 January 2018

1 reference

Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis

21 January 2018

1 reference

Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-alpha and macrophage inflammatory protein-2 production

21 January 2018

1 reference

NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells

21 January 2018

1 reference

Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells

21 January 2018

1 reference

Potential role of ursodeoxycholic acid in suppression of nuclear factor kappa B in microglial cell line (BV-2).

21 January 2018

1 reference

Ursodeoxycholic acid and chemoprevention of colorectal cancer

21 January 2018

1 reference

Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor

21 January 2018

1 reference

Repression of major histocompatibility complex IA expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein.

21 January 2018

1 reference

Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis

21 January 2018

1 reference

Bile acids with differing hydrophilic-hydrophobic properties do not influence cytokine production by human monocytes and murine Kupffer cells

21 January 2018

1 reference

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1042/CS20110184

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21854363 AND SRC:MED&resulttype=core&format=json

11 February 2020

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