S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used? (Q37901649)

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7 February 2020

review article

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title

S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used? (English)

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7 February 2020

1

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7 February 2020

author name string

Hening Lin

series ordinal

1

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25 August 2017

28 June 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21762947 AND SRC:MED&resulttype=core&format=json

7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21762947 AND SRC:MED&resulttype=core&format=json

7 February 2020

volume

39

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issue

5-6

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7 February 2020

page(s)

161-170

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A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

7 February 2020

cites work

1 reference

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Structural Insights into Radical Generation by the Radical SAM Superfamily

6 September 2017

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RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

6 September 2017

1 reference

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Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

6 September 2017

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RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

6 September 2017

1 reference

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Haploid genetic screens in human cells identify host factors used by pathogens

6 September 2017

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Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2

6 September 2017

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Control of radical chemistry in the AdoMet radical enzymes

6 September 2017

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Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

6 September 2017

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DNA methylation landscapes: provocative insights from epigenomics

6 September 2017

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Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases

6 September 2017

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The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

6 September 2017

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Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA

6 September 2017

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Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA

6 September 2017

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Aminopropyltransferases: function, structure and genetics

6 September 2017

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Regulation of p53 activity through lysine methylation

6 September 2017

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Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

6 September 2017

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S-adenosylmethionine: nothing goes to waste

6 September 2017

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The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate

6 September 2017

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Many paths to methyltransfer: a chronicle of convergence

6 September 2017

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Structure and catalytic mechanism of the human histone methyltransferase SET7/9

6 September 2017

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Structure and catalytic mechanism of a SET domain protein methyltransferase

6 September 2017

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Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis

6 September 2017

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

6 September 2017

1 reference

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m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts

6 September 2017

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A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis

6 September 2017

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Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.

6 September 2017

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HhaI methyltransferase flips its target base out of the DNA helix

6 September 2017

1 reference

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Enzymatic mechanism of tRNA (m5U54)methyltransferase

6 September 2017

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The catalytic mechanism and structure of thymidylate synthase

6 September 2017

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In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin

6 September 2017

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Enzymatic synthesis of 3-(3-amino-3-carboxypropyl) uridine in Escherichia coli phenylalanine transfer RNA: Transfer of the 3-amino-3-carboxypropyl group from S-adenosylmethionine

6 September 2017

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Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae

6 September 2017

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Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

6 September 2017

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DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae

6 September 2017

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Mechanistic understanding of Pyrococcus horikoshiiDph2, a [4Fe–4S] enzyme required for diphthamidebiosynthesis

6 September 2017

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Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis

23 June 2018

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3-(3-Amino-3-carboxypropyl)uridine. Structure of the nucleoside in Escherichia coli transfer ribonucleic acid that reacts with phenoxyacetoxysuccinimide

23 June 2018

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Biochemistry: A radically different enzyme

23 June 2018

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Escherichia coli cyclopropane fatty acid synthase: is a bound bicarbonate ion the active-site base?

1 September 2018

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The activity of Escherichia coli cyclopropane fatty acid synthase depends on the presence of bicarbonate

1 September 2018

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Two enzymes, BtaA and BtaB, are sufficient for betaine lipid biosynthesis in bacteria.

1 September 2018

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A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

1 September 2018

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Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase

1 September 2018

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Cyclopropane fatty acid synthase from Escherichia coli: enzyme purification and inhibition by vinylfluorine and epoxide-containing substrate analogues

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THE PATH OF HYDROGEN IN THE FORMATION OF CYCLOPROPANE FATTY ACIDS.

1 September 2018

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The isolation from ribonucleic acid of substituted uridines containing alpha-aminobutyrate moieties derived from methionine

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Identities and phylogenetic comparisons of posttranscriptional modifications in 16 S ribosomal RNA from Haloferax volcanii.

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Biosynthesis in vitro of 2-(3-amino-3-carboxypropyl)-isoxazolin-5-one, the neurotoxic amino acid in Lathyrus odoratus

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12 December 2020

The Radical SAM Superfamily

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Isolation and structure determination of the fluorescent base from bovine liver phenylalanine transfer ribonucleic acid

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3-(3-Amino-3-carboxypropyl)uridine: a novel modified nucleoside isolated from Escherichia coli phenylalanine transfer ribonucleic acid

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Presence of a hypermodified nucleotide in hela cell 18 S and Saccharomyces carlsbergensis 17 S ribosomal RNAs

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Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae

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Kinetic and catalytic mechanism of HhaI methyltransferase

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12 December 2020

10.1016/J.BIOORG.2011.06.001

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21762947 AND SRC:MED&resulttype=core&format=json

7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21762947 AND SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21762947

1 reference