Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. (Q37900938)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605 AND SRC:MED&resulttype=core&format=json

7 February 2020

review article

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title

Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605 AND SRC:MED&resulttype=core&format=json

7 February 2020

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605 AND SRC:MED&resulttype=core&format=json

Renato Mariani-Costantini

7 February 2020

3

1 reference

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7 February 2020

Giuseppe Palasciano

4

1 reference

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7 February 2020

Antonio Moschetta

5

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7 February 2020

author name string

Chiara Degirolamo

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7 February 2020

publication date

16 February 2011

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Wiley interdisciplinary reviews. Systems biology and medicine

7 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605 AND SRC:MED&resulttype=core&format=json

7 February 2020

volume

3

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7 February 2020

issue

5

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7 February 2020

page(s)

562-587

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Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

7 February 2020

cites work

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Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

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The RXR heterodimers and orphan receptors

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Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation

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Minireview: nuclear receptor coactivators--an update

21 January 2018

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A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex

21 January 2018

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The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.

21 January 2018

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Fat and beyond: the diverse biology of PPARgamma

21 January 2018

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

21 January 2018

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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

21 January 2018

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Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

21 January 2018

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Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor

21 January 2018

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PPARs: diverse regulators in energy metabolism and metabolic diseases

21 January 2018

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

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Novel peroxisome proliferator activated receptor-alpha agonists

21 January 2018

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Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy

21 January 2018

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Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease

21 January 2018

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Mechanism of action of fibrates on lipid and lipoprotein metabolism

21 January 2018

1 reference

The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans

21 January 2018

1 reference

Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells

21 January 2018

1 reference

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus

21 January 2018

1 reference

Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner

21 January 2018

1 reference

Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

21 January 2018

1 reference

Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis

21 January 2018

1 reference

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

21 January 2018

1 reference

Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

21 January 2018

1 reference

Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

21 January 2018

1 reference

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

21 January 2018

1 reference

Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators

21 January 2018

1 reference

Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects

21 January 2018

1 reference

Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives

21 January 2018

1 reference

Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes

21 January 2018

1 reference

Fenofibrate for cardiovascular disease prevention in metabolic syndrome and type 2 diabetes mellitus

21 January 2018

1 reference

Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation

21 January 2018

1 reference

Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia.

21 January 2018

1 reference

Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome

21 January 2018

1 reference

Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease

21 January 2018

1 reference

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

21 January 2018

1 reference

Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial

21 January 2018

1 reference

Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials

21 January 2018

1 reference

Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome

21 January 2018

1 reference

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

21 January 2018

1 reference

After the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: implications for fenofibrate

21 January 2018

1 reference

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

21 January 2018

1 reference

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

21 January 2018

1 reference

PPARalpha governs glycerol metabolism

21 January 2018

1 reference

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

21 January 2018

1 reference

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

21 January 2018

1 reference

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

21 January 2018

1 reference

Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases

21 January 2018

1 reference

PPAR delta: a dagger in the heart of the metabolic syndrome

21 January 2018

1 reference

Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation

21 January 2018

1 reference

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

21 January 2018

1 reference

Regulatory functions of PPARbeta in metabolism: implications for the treatment of metabolic syndrome

21 January 2018

1 reference

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects

21 January 2018

1 reference

Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men.

21 January 2018

1 reference

Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta -87T>C polymorphism and dietary fat in French-Canadians.

21 January 2018

1 reference

Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity

21 January 2018

1 reference

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

21 January 2018

1 reference

PPAR delta agonists and metabolic diseases

21 January 2018

1 reference

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

21 January 2018

1 reference

Regulation of muscle fiber type and running endurance by PPARdelta

21 January 2018

1 reference

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

21 January 2018

1 reference

AMPK and PPARdelta agonists are exercise mimetics

21 January 2018

1 reference

PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

21 January 2018

1 reference

Activation of PPARdelta alters lipid metabolism in db/db mice.

21 January 2018

1 reference

Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys

21 January 2018

1 reference

The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

21 January 2018

1 reference

Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.

21 January 2018

1 reference

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home

21 January 2018

1 reference

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

21 January 2018

1 reference

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

21 January 2018

1 reference

Transcriptional control of adipocyte formation

21 January 2018

1 reference

Adipocyte differentiation from the inside out

21 January 2018

1 reference

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

21 January 2018

1 reference

PPAR gamma is required for placental, cardiac, and adipose tissue development

21 January 2018

1 reference

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance

21 January 2018

1 reference

PPAR gamma and human metabolic disease

21 January 2018

1 reference

Functional implications of genetic variation in human PPARgamma

21 January 2018

1 reference

New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand

21 January 2018

1 reference

A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy

21 January 2018

1 reference

The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes

21 January 2018

1 reference

Retinoid x receptor heterodimers in the metabolic syndrome

21 January 2018

1 reference

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

21 January 2018

1 reference

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

1 reference

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

21 January 2018

1 reference

PPAR-gamma agonists and their role in type 2 diabetes mellitus management

21 January 2018

1 reference

Cidea is associated with lipid droplets and insulin sensitivity in humans

21 January 2018

1 reference

Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.

21 January 2018

1 reference

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

21 January 2018

1 reference

PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene

21 January 2018

1 reference

Fat poetry: a kingdom for PPAR gamma

21 January 2018

1 reference

Oral antihyperglycemic therapy for type 2 diabetes mellitus.

21 January 2018

1 reference

PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

21 January 2018

1 reference

Insulin sensitivity: modulation by nutrients and inflammation

21 January 2018

1 reference

Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation

21 January 2018

1 reference

Role of peroxisome proliferator-activated receptor gamma in glucose-induced insulin secretion

21 January 2018

1 reference

Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

21 January 2018

1 reference

Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter

21 January 2018

1 reference

Inflammation and metabolic disorders

21 January 2018

1 reference

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

21 January 2018

1 reference

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

21 January 2018

1 reference

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

1 reference

Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue.

21 January 2018

1 reference

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

21 January 2018

1 reference

Macrophage peroxisome proliferator activated receptor gamma as a therapeutic target to combat Type 2 diabetes

21 January 2018

1 reference

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone

21 January 2018

1 reference

Muscle-specific Pparg deletion causes insulin resistance

21 January 2018

1 reference

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

21 January 2018

1 reference

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

21 January 2018

1 reference

Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages

21 January 2018

1 reference

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

21 January 2018

1 reference

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology

21 January 2018

1 reference

Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity

21 January 2018

1 reference

PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

21 January 2018

1 reference

The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

21 January 2018

1 reference

A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily

21 January 2018

1 reference

LXR, a nuclear receptor that defines a distinct retinoid response pathway

21 January 2018

1 reference

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

Liver X Receptor Signaling Pathways in Cardiovascular Disease

21 January 2018

1 reference

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

1 reference

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

21 January 2018

1 reference

Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice

21 January 2018

1 reference

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

21 January 2018

1 reference

A transcriptional co-repressor that interacts with nuclear hormone receptors

21 January 2018

1 reference

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

1 reference

Liver X receptors as integrators of metabolic and inflammatory signaling

21 January 2018

1 reference

Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

21 January 2018

1 reference

Autoregulation of the human liver X receptor alpha promoter

21 January 2018

1 reference

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages

21 January 2018

1 reference

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

21 January 2018

1 reference

Accumulation of foam cells in liver X receptor-deficient mice

21 January 2018

1 reference

Atherosclerosis. the road ahead

21 January 2018

1 reference

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

21 January 2018

1 reference

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

21 January 2018

1 reference

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

21 January 2018

1 reference

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

21 January 2018

1 reference

Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene

21 January 2018

1 reference

The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c

21 January 2018

1 reference

Apolipoprotein E and atherosclerosis

21 January 2018

1 reference

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

1 reference

Liver X receptor agonists inhibit tissue factor expression in macrophages

21 January 2018

1 reference

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

1 reference

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways

21 January 2018

1 reference

Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine

21 January 2018

1 reference

Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo

21 January 2018

1 reference

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

1 reference

Genetic basis of sitosterolemia

21 January 2018

1 reference

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

21 January 2018

1 reference

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

21 January 2018

1 reference

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

21 January 2018

1 reference

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

21 January 2018

1 reference

LXRs regulate the balance between fat storage and oxidation.

21 January 2018

1 reference

The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

1 reference

Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

21 January 2018

1 reference

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

21 January 2018

1 reference

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

21 January 2018

1 reference

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

1 reference

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 January 2018

1 reference

Research resource: nuclear hormone receptor expression in the endocrine pancreas

21 January 2018

1 reference

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

21 January 2018

1 reference

SREBPs: transcriptional mediators of lipid homeostasis

21 January 2018

1 reference

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

21 January 2018

1 reference

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

21 January 2018

1 reference

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

21 January 2018

1 reference

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

21 January 2018

1 reference

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

21 January 2018

1 reference

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

21 January 2018

1 reference

Identification of a nuclear receptor that is activated by farnesol metabolites

21 January 2018

1 reference

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

1 reference

Cholesterol gallstone disease.

21 January 2018

1 reference

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

21 January 2018

1 reference

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

21 January 2018

1 reference

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

21 January 2018

1 reference

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

21 January 2018

1 reference

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

21 January 2018

1 reference

Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha.

21 January 2018

1 reference

The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes

21 January 2018

1 reference

Identification of DRIP205 as a coactivator for the Farnesoid X receptor.

21 January 2018

1 reference

Methylation at arginine 17 of histone H3 is linked to gene activation

21 January 2018

1 reference

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

21 January 2018

1 reference

Identification of a chemical tool for the orphan nuclear receptor FXR.

21 January 2018

1 reference

The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors

21 January 2018

1 reference

A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

1 reference

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

21 January 2018

1 reference

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

1 reference

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid

21 January 2018

1 reference

Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

21 January 2018

1 reference

Identification of gene-selective modulators of the bile acid receptor FXR.

21 January 2018

1 reference

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

21 January 2018

1 reference

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

21 January 2018

1 reference

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

21 January 2018

1 reference

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

21 January 2018

1 reference

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption

21 January 2018

1 reference

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

21 January 2018

1 reference

Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids

21 January 2018

1 reference

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

21 January 2018

1 reference

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

1 reference

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

1 reference

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

21 January 2018

1 reference

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

21 January 2018

1 reference

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

1 reference

The effects of cholestyramine on high density lipoprotein metabolism

21 January 2018

1 reference

Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.

21 January 2018

1 reference

Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA.

21 January 2018

1 reference

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

1 reference

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

1 reference

Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety

21 January 2018

1 reference

Serum Lipids in Cholelithiasis: Effect of Chenodeoxycholic Acid Therapy

21 January 2018

1 reference

Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4.

21 January 2018

1 reference

A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids

21 January 2018

1 reference

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

21 January 2018

1 reference

Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

21 January 2018

1 reference

Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

1 reference

FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

21 January 2018

1 reference

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

21 January 2018

1 reference

Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

21 January 2018

1 reference

Bile acid sequestrants and the treatment of type 2 diabetes mellitus

21 January 2018

1 reference

The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition

21 January 2018

1 reference

Glucose regulates the expression of the farnesoid X receptor in liver

21 January 2018

1 reference

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

21 January 2018

1 reference

Regulation of carbohydrate metabolism by the farnesoid X receptor

21 January 2018

1 reference

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

21 January 2018

1 reference

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

21 January 2018

1 reference

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

1 reference

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

21 January 2018

1 reference

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 January 2018

1 reference

Intestinal ecology in the metabolic syndrome

21 January 2018

1 reference

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

21 January 2018

1 reference

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

FXR-mediated regulation of eNOS expression in vascular endothelial cells

21 January 2018

1 reference

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

21 January 2018

1 reference

Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells

21 January 2018

1 reference

Expression and activation of the farnesoid X receptor in the vasculature

21 January 2018

1 reference

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

21 January 2018

1 reference

Effects of FXR in foam-cell formation and atherosclerosis development

21 January 2018

1 reference

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

21 January 2018

1 reference