Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders (Q37896718)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21722302 AND SRC:MED&resulttype=core&format=json

6 February 2020

review article

1 reference

title

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders (English)

1 reference

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endoplasmic reticulum stress

6 February 2020

main subject

endoplasmic reticulum

0 references

3 references

25 April 2019

8 August 2019

8 September 2019

1 reference

PubMed

regulation of gene expression

8 August 2019

1 reference

8 September 2019

1

1 reference

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6 February 2020

Adrienne M Gorman

3

1 reference

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6 February 2020

Afshin Samali

6

1 reference

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6 February 2020

author name string

Donna Kennedy

2

1 reference

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6 February 2020

Sanjeev Gupta

4

1 reference

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6 February 2020

Sandra J M Healy

5

1 reference

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6 February 2020

publication date

1 October 2011

4 references

25 April 2019

8 August 2019

8 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21722302 AND SRC:MED&resulttype=core&format=json

Journal of Cellular and Molecular Medicine

6 February 2020

published in

4 references

25 April 2019

8 August 2019

8 September 2019

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6 February 2020

volume

15

1 reference

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6 February 2020

issue

10

1 reference

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6 February 2020

page(s)

2025-2039

1 reference

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Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y Cells

6 February 2020

cites work

1 reference

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Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

6 September 2017

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

6 September 2017

1 reference

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HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction

6 September 2017

1 reference

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

6 September 2017

1 reference

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Mitochondrial dysfunction is a converging point of multiple pathological pathways in amyotrophic lateral sclerosis

6 September 2017

1 reference

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

6 September 2017

1 reference

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Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization

6 September 2017

1 reference

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Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

6 September 2017

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

6 September 2017

1 reference

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The role of the Atg1/ULK1 complex in autophagy regulation

6 September 2017

1 reference

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

6 September 2017

1 reference

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ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

6 September 2017

1 reference

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The unfolded protein response and its relevance to connective tissue diseases.

6 September 2017

1 reference

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mTOR signaling at a glance

6 September 2017

1 reference

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Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

6 September 2017

1 reference

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Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

6 September 2017

1 reference

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Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

6 September 2017

1 reference

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

6 September 2017

1 reference

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

6 September 2017

1 reference

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Bcl-2 family on guard at the ER.

6 September 2017

1 reference

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Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

6 September 2017

1 reference

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The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

6 September 2017

1 reference

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

6 September 2017

1 reference

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

6 September 2017

1 reference

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A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

6 September 2017

1 reference

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Protective effect against Parkinson's disease-related insults through the activation of XBP1

6 September 2017

1 reference

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One step at a time: endoplasmic reticulum-associated degradation

6 September 2017

1 reference

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Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

6 September 2017

1 reference

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Research in motion: the enigma of Parkinson's disease pathology spread

6 September 2017

1 reference

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Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

6 September 2017

1 reference

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Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

6 September 2017

1 reference

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JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

6 September 2017

1 reference

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Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

6 September 2017

1 reference

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ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

6 September 2017

1 reference

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Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

6 September 2017

1 reference

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Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress

6 September 2017

1 reference

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Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

6 September 2017

1 reference

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TDP-43 A315T mutation in familial motor neuron disease

6 September 2017

1 reference

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Protein misfolding and neurodegeneration

6 September 2017

1 reference

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The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

6 September 2017

1 reference

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IRE1 signaling affects cell fate during the unfolded protein response

6 September 2017

1 reference

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Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

6 September 2017

1 reference

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

6 September 2017

1 reference

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XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

6 September 2017

1 reference

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Novel therapeutic strategies for the treatment of protein-misfolding diseases

6 September 2017

1 reference

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Signal integration in the endoplasmic reticulum unfolded protein response

6 September 2017

1 reference

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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

6 September 2017

1 reference

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Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

6 September 2017

1 reference

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Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

6 September 2017

1 reference

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Cell death in the nervous system

6 September 2017

1 reference

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Autophagy is activated for cell survival after endoplasmic reticulum stress

6 September 2017

1 reference

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 September 2017

1 reference

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Apoptosome: a platform for the activation of initiator caspases

6 September 2017

1 reference

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Mediators of endoplasmic reticulum stress-induced apoptosis

6 September 2017

1 reference

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Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

6 September 2017

1 reference

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6 September 2017

1 reference

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Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment

6 September 2017

1 reference

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

6 September 2017

1 reference

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Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

6 September 2017

1 reference

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The pathobiology of amyotrophic lateral sclerosis: a proteinopathy?

6 September 2017

1 reference

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The mammalian unfolded protein response

6 September 2017

1 reference

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

6 September 2017

1 reference

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A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

6 September 2017

1 reference

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PET imaging of amyloid in Alzheimer's disease.

6 September 2017

1 reference

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Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

6 September 2017

1 reference

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Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

6 September 2017

1 reference

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Regulation of the expression and processing of caspase-12

6 September 2017

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Unfolding the role of protein misfolding in neurodegenerative diseases

6 September 2017

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Orchestrating the unfolded protein response in health and disease

6 September 2017

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Toxic proteins in neurodegenerative disease

6 September 2017

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Mitochondria in apoptosis and human disease

6 September 2017

1 reference

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

6 September 2017

1 reference

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Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway

6 September 2017

1 reference

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The unfolded protein response and Alzheimer's disease

6 September 2017

1 reference

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Alzheimer's disease: genes, proteins, and therapy

6 September 2017

1 reference

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Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Regulated translation initiation controls stress-induced gene expression in mammalian cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Mice devoid of PrP are resistant to scrapie

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Caspase-4 is partially cleaved by calpain via the impairment of Ca2 homeostasis under the ER stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

VAPB interacts with and modulates the activity of ATF6.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Mutant prion proteins are partially retained in the endoplasmic reticulum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Prion protein protects human neurons against Bax-mediated apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Regulation of apoptosis by the unfolded protein response.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

AMP-activated protein kinase: a universal regulator of autophagy?

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

The unfolded protein response is involved in the pathology of Alzheimer's disease.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Protein aggregation after transient cerebral ischemia.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Prion Protein-Deficient Cells Show Altered Response to Oxidative Stress Due to Decreased SOD-1 Activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Amyloid β accumulation in axons after traumatic brain injury in humans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Prions prevent neuronal cell-line death.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394214

10.1111/J.1582-4934.2011.01374.X

1 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21722302 AND SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21722302 AND SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

21722302

1 reference