Structure, function, and mechanism of progranulin; the brain and beyond (Q37892442)

24 August 2017

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title

Structure, function, and mechanism of progranulin; the brain and beyond (English)

1 reference

24 August 2017

Huishi Toh

1

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24 August 2017

Babykumari P Chitramuthu

series ordinal

2

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24 August 2017

Hugh P J Bennett

series ordinal

3

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24 August 2017

Andrew Bateman

series ordinal

4

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24 August 2017

publication date

21 June 2011

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Journal of Molecular Neuroscience

24 August 2017

published in

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24 August 2017

volume

45

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24 August 2017

issue

3

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24 August 2017

page(s)

538-548

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Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging

24 August 2017

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Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.

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Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

21 January 2018

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Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells

21 January 2018

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ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor

21 January 2018

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

21 January 2018

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Growing a tumor stroma: a role for granulin and the bone marrow

21 January 2018

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The granulin gene family: from cancer to dementia

21 January 2018

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Granulins, a novel class of peptide from leukocytes

21 January 2018

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Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

21 January 2018

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Structural and functional analysis of a promoter of the human granulin/epithelin gene

21 January 2018

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The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

21 January 2018

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Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

21 January 2018

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Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation.

21 January 2018

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The zebrafish progranulin gene family and antisense transcripts

21 January 2018

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https://api.crossref.org/works/10.1007/S12031-011-9569-4

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma

21 January 2018

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https://api.crossref.org/works/10.1007/S12031-011-9569-4

Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance

21 January 2018

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https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1

21 January 2018

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https://api.crossref.org/works/10.1007/S12031-011-9569-4

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

21 January 2018

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https://api.crossref.org/works/10.1007/S12031-011-9569-4

Expression of progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Cellular localization of gene expression for progranulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Gene expression profiling of cutaneous wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Spatiotemporal expression pattern of progranulin in embryo implantation and placenta formation suggests a role in cell proliferation, remodeling, and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Chronic Traumatic Encephalopathy: A Potential Late Effect of Sport-Related Concussive and Subconcussive Head Trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Fishing for genes controlling development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin is a mediator of the wound response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Traumatic brain injury may increase the risk for frontotemporal dementia through reduced progranulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

PC cell-derived growth factor overexpression promotes proliferation and survival of laryngeal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Age-Dependent Changes in Progranulin Expression in the Mouse Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin expression is upregulated after spinal contusion in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Transforming growth factor e: amino acid analysis and partial amino acid sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin expression in the developing and adult murine brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Zebrafish: an integrative system for neurogenomics and neurosciences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin is expressed within motor neurons and promotes neuronal cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Development and application of mass spectrometric methods for the analysis of progranulin N-glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Expression Pattern of Progranulin in the Human Placenta and Its Effect on Cell Proliferation in the Choriocarcinoma Cell Line BeWo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Granulin precursor gene: a sex steroid-inducible gene involved in sexual differentiation of the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

Production of clones of homozygous diploid zebra fish (Brachydanio rerio)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12031-011-9569-4

The interactomics of sortilin: an ancient lysosomal receptor evolving new functions

21 January 2018

1 reference

12 December 2020

Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival.

1 reference

12 December 2020

Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo

1 reference

12 December 2020

Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium

1 reference

12 December 2020

Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein

1 reference

12 December 2020

Neurotrophins and their receptors in early development of the mammalian nervous system

1 reference

12 December 2020

The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth

1 reference

12 December 2020

Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters

1 reference

12 December 2020

PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma

1 reference

12 December 2020

Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption

1 reference

12 December 2020

Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis

1 reference

12 December 2020

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury

1 reference

12 December 2020

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

1 reference

12 December 2020

Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression

1 reference

12 December 2020

Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis

1 reference

12 December 2020

In silico comparison of the transcriptome derived from purified normal breast cells and breast tumor cell lines reveals candidate upregulated genes in breast tumor cells

1 reference

12 December 2020

Biological activities and signaling pathways of the granulin/epithelin precursor

1 reference

12 December 2020

GEP, a local growth factor, is critical for odontogenesis and amelogenesis.

1 reference

12 December 2020

Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

1 reference

12 December 2020

Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex

1 reference

12 December 2020

The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.

1 reference

12 December 2020

10.1007/S12031-011-9569-4

Identifiers

DOI

1 reference

24 August 2017

1 reference